羟基磷灰石表面改性的研究进展

*200237WD09130082010-12-172011-03-28HAP。。HAPHAP。3、HAP。ResearchProgressontheSurfaceModificationofHydroxyapatiteWangYanXiaoYanLangMeidong*KeyLaboratoryforUltrafineMaterialsofMinistryofEducationSchoolofMaterialsScienceandEngineeringEastChinaUniversityofScienceandTechnologyShanghai200237AbstractHydroxyapatiteHAPhasbeenwidelyusedinthecompositesduetoitsbiocompatibilityandosteoinductivity．Howevertheeasilyaggregationandpooradhesionwithpolymermatrixreducethemechanicalandbiologicalproperties．SurfacemodificationofHAPnotonlypreventstheHAPparticlesfromaggregatingandenhancesthecompatibilitywithpolymermatrixbutalsogivesHAPparticlesnovelpropertiesforperspectiveapplications．InthispaperthegeneralpreparationmethodsofsurfacemodificationofHAPincludingcouplingagentsesterificationreactionandgraftingpolymerwerereviewed．TheeffectsonthepropertiesofHAPwerealsoinducedbriefly．KeywordsHydroxyapatiteHAPSurfacemodificationMechanicalpropertiesDispersibilityHAP70%1。、。HAP、23。HAPHAPHAP。HAP。HAPHAP。、HAP。HAPHAP。HAP31123。HAP。·387·http//．hxtb．org20117491HAPFig．1SchematicillustrationofsurfacemodificationofHAP1HAPHAPHAP。HAP、。Liu4HAPHMDIICEMHAPEIABIC。Misra52-HAP2HAPHAP50%。Vaz652、2、1HAP-EVA。HAP7。Y-R-Si-X3Y、、X、。SiXSiOHHAPHAP、HAPHAPHAP。1HAP。1Tab．1SilanecouplingagentsandtheirstructureA-1110γ-NH2CH23SiOCH3371617A-1100γ-NH2CH23SiOC2H538～12A-187γ-23-H2CCOHCH2OCH23SiOCH331314A-174γ-CH2=CCH3COOCH23SiOCH3315～23A-1120N-β--γ-NH2CH22NHCH23SiOCH33121617A-1130NH2CH22NHCH23NHCH23SiOCH331214A-151CH2=CHSiOC2H5325A-171CH2=CHSiOCH331617CH3CH217SiCl326Fan8γ-A-1110HAP-PLGAHAP/PLGA、。Furozono9γ-A-1100HAPPAA。Zhang10HAP。Durrieu11A-1100HAPNH2N--3-HAP。Furuzono12A-1100HAP。daSilva133A-1100、N-β--γ-A-1120A-1130HAPCu2+Co2+。·487·2011749http//．hxtb．org14γ-23-A-187HAPPCHAP/PC。Damia15A-1130A-187HAPHAPHAP。Oliveira16γ-A-174HAP。Dupraz1718A-1745HAP。Santos19A-174HAPABisGMA。20A-174HAPHAP/HDPE。21A-174HAP。Wang22232HAPA-174PAA。HAP。Wang24A-174HAPPLLApH。Tanaka25HMDSHAPP—OHSi—CH33500℃Si—CH33Si—OHHMDS。Wen26A-151HAPPMVS。Wang27OTSHAPPLLA/HAP32。2HAP。HAPP—OHHAPP—OHHAP、、、P—OHHAP。D’Andrea28RPOOH2R=n-C18H17n-C18H37n-C8F17CH22HAP。Tanaka29HAPH4P2O7P—OH1ROH+H4P2O7→ROPOOH2+H3PO41P—OHHAP30HAPBSA、MGBLSZ31。Pramanik323-CEPAHAPEVAHAP。Torres33HAPHAPAgHAP。Hammari34PPOHPPHHAPPPOH140m2/g267m2/g。Aissa35HAP。Hammari362HAPHAPHAP。37HAPHAP。Nancollas386HAPHAP。·587·http//．hxtb．org201174939HAP-HAPHAP40。HAP、41423HAPHAP43。Nicholas44HAPHAPHAP65dHAPSiO245HAPSiO2。3HAP。HAP。HAP。Liu46HMDIICEMHAPPMMA、PBMAPHEMAHMDIHAPPEG47/PolyactiveTM70/3048。Matsuda49HAPPMMA。Zhao50HAPWBPUHAP、。Gong51A-151HAPStPStPSt。Wang52A-11002-HAPBrATRPHAPPMMAHAP。Wang53reverseATRPHAPPMMA。Jing54HAPN-PNIPAMHAP。Wei55A-1100HAPL--γ-BLG-NCA。Yang56A-1100RGD。HAPHAPHAPPLLAPCL。PLLAPCLHAPHAPPLLAPCL。Jing57PLLA。HAPLLAPLLA6%PLLA/HAPPLLA、PLLAHAP58。HAP59。HongPLGA、6061。HAPPLLAHAPHAPLLAPLLA14%LLA62。Li63PLLAPLLA。PCLHAPPCL。Azevedo·687·2011749http//．hxtb．org64PCLHAPHAP/PCL。Wang65PCL6%50%。Lee663HAP、HAPPEGHAPPEGHAP33PCL8.4%、9.5%24.6%。PCLPCL67。Wang68HMDIHAPEGPDOPPDOPPDO。Zeng69HAPATRPHAPPHEMAPHEMAPCL55.9%。HAP。CHAHAPK2S2O8/Na2S2O5GMA70PGMACHA。71。Choi72HAPHAP。Kim732--2--2-EGMP1--3-3-EDCHAPHAPHAP。。Gong74HAPPStHIPS、。75HAP/StHAP/A-151/StHAPHAP/A-151/StPSt。Nichols76HAPHAP。Lee77Ca2+EGMP。HAPCa2+HAP。Liu78PAAHAPCa2+HAPPolyactiveTM70/30。7980MAHAPHAPHAPMAPVAPVA。Qiu81HAPCa2+PLLAPBSpH7.4。HAPPLLA82PLLA。83。84HAPPLGA。Cui85HAPPLGA10%20%HAP。Tanaka86HAPHAPH2OCO2。Li87NaOLPEOHAP。Li88SAHAPSA。89SAHAPPC。HAPHAP。Chen90HAP。Wilson91·787·http//．hxtb．org2011749HAPHAP85m2/g160m2/gHAP。Rai92LBLHAP、3。。PHBV30%93。4、。123。。1．200728430～31.2．2008274603～610.3CCPMVerheyenJRdeWijnCAvanBlitterswijketal．J．Biomed．Mater．Res．1993274433～444.4QLiuJRdeWijnCAvanBlitterswijk．J．Biomed．Mater．Res．199840358～364.5DNMisra．J．Dent．Res．1985121405～1408.6CMVazRLReisAMCunha．Biomaterials200223629～635.7JFZhaoTFuYHanetal．Mater．Lett．200358163～168.8XFanJChenJMRuanetal．Polym．Plast．Technol．Eng．200948658～664.9TFuruzonoKSonodaJTanaka．J．Biomed．Mater．Res．2001569～16.10SMZhangSPLiYHYanetal．J．WuhanUniv．Tech．-Mater．Sci．Ed．200116337～38.11MCDurrieuSPalluFGuillemotetal．J．Mater．Sci．Mater．Med．200415779～786.12TFurozonoPLWangAKorematsuetal．J．Biomed．Mater．Res．PartB200365B217～226.13OGdaSilvaECdaSilvaFilhoMGdaFonsecaetal．J．ColloidInterf．Sci．2006302485～491.14．2008231145～149.15CDamiaPSharrock．Mater．Lett．2006603192～3196.16JMOliveiraTMiyazakiMALopesetal．J．Mater．Sci．Mater．Med．200516253～259.17AMPDuprazJRdeWijnSATvdMeeretal．J．Biomed．Mater．Res．199630231～238.18AMPDuprazSATvdMeerJRdeWijn．J．Mater．Sci．Mater．Med．19967731～738.19CSantosRLClarkeMBradenetal．Biomaterials2002231897～1904.20．200711381912～1915.21．2009312428～43.22MWangSDebWBonfield．Mater．Lett．200044119～124.23MWangWBonfield．Biomaterials2001221311～1320.24XJWangGJSongTLou．Med．Eng．Phys．201032391～397.25HTanakaTWatanabeMChikazawaetal．J．ColloidInterf．Sci．1998206205～211.26JQWenYBLiYZuoetal．Mater．Lett．2008623307～3309.27CLYangKChengWJWengetal．J．Mater．Sci．Mater．Med．200920667～672.28SCD’AndreaAYFadeev．Langmuir2003197904～7910.29HTanakaMFutaokaRHino．J．ColloidInterf．Sci．2004269358～363.30HTanakaMFutaokaRHinoetal．J．ColloidInterf．Sci．2005