SSRI和SNRI类抗抑郁药的不良反应

7920109September,2010,Vol.7,No.9SSRISNRI12*22232110005021000503100050R916.62;R994.11A1672-8629201009-0554-02SSRISNRI。2010SSRISNRI24。SSRI/SNRI、。SSRISNRI。5-5-/AdverseDrugReactionInducedbyAntidepressantsofSSRIandSNRIZHANGYing1CUIXiang-li2*YANGPing2JIAYing2LIUJing2PANHua3ZHAOZhi-gang2(1PharmaceuticalEquipmentandMaterialManagement,TiantanHospital,CapitalMedicalUniversity,Beijing100050China;2DepartmentofPharmacy,TiantanHospital,CapitalMedicalUniversity,Beijing100050China;3NeurologyDepartment,TiantanHospital,CapitalMedicalUniversity,Beijing100050,China)Abstract:ObjectiveTostudytheclinicalsyndromofadversedrugreaction(ADR)inducedbySSRIorSNRI,andthetreatmentofADR.Methods24depressioncaseswithADRinducedbySSRIorSNRIwerecollectedinneu－rologicaloutpatientsfromJanuary,2010toJune,2010,weanalysisedtheclinicalsyndromsofADRinducedbySSRIorSNRI,andde-scribedthetreatmentofdifferentADR.ResultsThemostcommonADRisGastrointestinaltractreaction,lesscommanADRarePsychiatricsymptoms,autonomicnervoussystemdysfunctionandextrapyramidalreaction.ConclusionAlthoughSSRIandSNRIaremostsafeantidepressants,neurologistsshouldpaymuchattentiontotheirADR,andgraspthetreatmentmeasures.Keywords:selectiveserotoninreuptakeinhibitors(SSRI);serotonin/norepinephrinereuptakeinhibitors(SNRI);adversedrugreaction(ADR);treatmentmeasures。*。E-mail:[e-mail]25-SSRI5-/SNRISSRI、、、SNRI、。、[1]。SSRI、。SSRI5-HT。SNRI5-5-HTNATCATCA[2]。SSRI/SNRI[3]SSRI/SNRI1SSRI/SNRI2420101～6101421～7340.2。121428。8、4661～481220mg/d20mg/d50mg/d75mg/d。22.11～4··5547920109September,2010,Vol.7,No.9、、。241～28。4334282kg。、。SSRI3～14。2.2SSRI41～22、12。21210mg。2.3422241112。2.424223。33.1SSRI/SNRI310SS-RI/SNRI3、[4]SSRI。TCA1、、、、、、。SSRI/SNRITCA、1H1[5]TCA、、、。SSRI5-HT5-HT15-HT2、、5-HT3、、SSRI、。SNRI5-HTNE5-HTNE。、[6]。SSRI/SNRI1～2[7]。。3.2。2～4。。[8]。2。SSRI。SSRIMAOI5-HT、、MAOISSRI1～2。SSRI/SNRI。。[1],,.[M].16.:,2006:286-299.[2],.[J].,2005,9:131-133.[3]SantosMA,RochaFL,HaraC.Efficacyandsafetyofantidepres-santaugmentationwithlamotrigineinpatientswithtreatment-resistantdepression:arandomized,placebo-controlled,double-blindstudy[J].PrimCareComJClinPsyc,2008,10(3):187-190.[4],,,.2005～2007αα5557920109September,2010,Vol.7,No.9[J].,2008,8833-836.[5]ThaseME,SheltonRC,KhanA.TreatmentwithvenlafaxineextendedreleaseafterSSRInonresponseorintolerance:arandomizedcomparisonofstandard2andhigher2dosingstrategies[J].JClinPsychopharmacol,2006,26(3):250-258.[6].[J].,2004,37:275-277.[7]DavidN.JuurlinkDN,MamdaniMM,KoppA,etal.TheRiskofSuicideWithSelectiveSerotoninReuptakeInhibitorsintheElderly[J].AmJPsychia,2006,163:813-821.[8]GandaraDL,AgueraL,RojoJE,eta1.Useofantidepressantcombinations:which,whenandwhy?ResultsofaSpanishsurvey[J].ActaPsyehiatrSeand,2005,112(suppl428):32-35.2010-06-23106332000R916.693R994.11A1672-8629201009-0556-022009。2009106。、、。。Analysisof106CasesofAdverseDrugReactionsInducedbyAntibacterialsZHANGHua-fengLUOTingXUJingLILiPENGGui-qingZHUYu-hua(Jiujianguniversityclinicalcollege,JiangxiJiujiang332000,China)AbstractObjectiveTostudytheoccurrenceanddistributionofadversedrugreactions(ADR)inducedbyantibacterialsinourhospitaltoprovidereferencetoclinicalrationaldruguseofantibacterialagents.Methods106reportsofADRcasesinducedbyantibacterialsfrom2009inourhospitalclinicaldepartmentswerecollectedandanalyzedret-rospectivelybydrugtypes,drugnames,routeofadministrationandclinicalmanifestations.ResultsAntibacterialshadoccupiedthefirstplaceinourhospital'sadversedrugreaction,mostofthemresultedfromcephalosporins,macrolidesandquinolones.ConclusionItisnecessarytopaymoreattentiontheADRinducedbyantibacterialstopromotetherationaluseofantibacterials.Keywords:antibacterialagent;adversedrugreaction;analysis20092079。(ADR)。ADRADR。2009ADR。11.1ADR2009ADR106。1.2ADR、ADR。22.12009“”10699、2、5。2.2ADR8983.96％1716.04%。!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!556