富血小板血浆正在成为临床治疗的新希望-单桂秋

*2009B08070109210C360916712011ZXJ09104-07C1963．10～[e-mail]··*510010R457.1R331.1+43A1004-549X201104-0267-03、。2060、。1、。2070plateletrichplasmaPRPHarke11977PRP。1993Hood2PRPplateletgelPG。、、、、、、。1PRPPRP2。PRPPRP。。。PRP、。PRPPRP。2PRP2．1PRP3———PDGF、βTGF-β、VEGF、EGF、FGF、IGF、BDNF、1IL-1———。、。PRP4～8PDGF、TGF-β、VEGFEGF3～84PPP。PRPPGPRP。PRP、、、。2．2PRP。PRP。1992Yeaman51、、6。20027-4PF-4、RANTES、-3CTAP-3、PBP、β-4Tβ-4、BFP-B、AFP-A、、7·762·2011042404ChinJBloodTransfusionApril2011Vol．24No．048。3PRPPRPPRP、PRPPG、PGPRP4。PRPPRPPRP2。PRPPRP。3．1PRPPRP、、、、PRP、、、。1997Whit-man9PRG。Hom1084mmPG42d。Brown11PG24hPG。Vang12PG、。Michael13PG、、。2008PRP142PRP14。15PRP。16PRPPRP。3．2PRPPRPPRP、、PRP。PRP、、。PRP。Smrke172007ABORhD、、PG6HLA-Ⅰ。2PRPPRP115174、11、1、11819CHEN20PRP17。PRP。3．3PRP。2090。ScienceNature。20112AAOS2011LiebergallPRP。FG、PRPBMSCs1FG、BMSCs、PRP、。、、、、1。、、、、。、3PRP、、。PRP。。4PG、OG、PRPPGPRPPRP1000×109/LPRP10∶1PG、PG·862·2011042404ChinJBloodTransfusionApril2011Vol．24No．04PGPGPG1、。5PRP、、。、、、、PRP、。PRPPRPPRP、。1HarkeHTangerDFürst-DenzerSetal．Effectofapreoperativeseparationofplateletsonthepostoperativebloodlosssubsequenttoextracorporealcirculationinopenheartsurgeryauthor'stransl．Anaesthesist197726264-71．2HoodAGHillAGReederGD．Perioperativeautologoussequestra-tionIIIanewphysilolgicgluewithwoundhealingproperties．ProcAmAcadCardiovascPerfusion1993141126-129．3FreiRBioscaFEHandlMetal．Theroleofgrowthfactorsinthehumanorganismandtheiruseinmedicineespeciallyinorthope-dicsandtraumatology．ActaChirOrthopTraumatolCech2008754247-252．4GlenisterKMPayneKASparrowRL．Proteomicanalysisofsuper-natantfrompooledbuffy-coatplateletconcentratesthroughout7-daystorage．Transfusion200848199-107．5YeamanMRPuentesSMNormanDCetal．Partialcharacteriza-tionandstaphylocidalactivityofthrombin-inducedplateletmicrobi-cidalprotein．InfectImmun19926031202-1209．6YeamanMRTangYQShenAJetal．Purificationandinvitroac-tivitiesofrabbitplateletmicrobicidalproteins．InfectImmun19976531023-1031．7TangYQYeamanMRSelstedME．Antimicrobialpeptidesfromhumanplatelets．InfectImmun200270126524-6533．8MercierRCDietzRMMazzolaJL．BeneficialinfluenceofplateletsonantibioticefficacyinaninvitromodelofStaphylococcusaureus-inducedendocarditis．AntimicrobAgentsChemother20044872551-2557．9WhitmanDHBerryRLGreenDM．Plateletgelanautologousal-ternativetofibringluewithapplicationsinoralandmaxillofacial-surgery．JOralMaxillofacSurg199755111294-1299．10HomDBLinzieBMHuangTC．Thehealingeffectsofautologousplateletgelonacutehumanskinwounds．ArchFacialPlastSurg200793174-183．11BrownSAAppeltEALipschitzA．Plateletgelsealantuseinrhyt-idectomy．PlastReconstrSurg200611841019-1025．12VangSNBradyCPChristensenKA．Autologousplateletgelincor-onaryarterybypassgraftingeffectsonsurgicalwoundhealing．Ex-traCorporTechnol200739131-38．13GardnerMJDemetrakopoulosDKlepchickPRetal．Theefficacyofautologuousplateletgelinpaincontrolandbloodlossintotalkneearthroplasty．IntOrthop2007316309-313．14．PG．2008235．15．PG．200724111875-1877．16．．2004394269-272．17SmrkeDGubinaBDomanovicDetal．Allogeneicplateletgelwithautologouscancellousbonegraftforthetreatmentofalargebonedefect．EurSurgRes2007393170-174．18BalboRAvontoIMarenchinoDetal．Plateletgelforthetreat-mentoftraumaticlossoffingersubstance．BloodTransfus201084255-259．19BernuzziGTarditoSBussolatiOetal．Plateletgelinthetreat-mentofcutaneousulcerstheexperienceoftheImmunohaematolo-gyandTransfusionCentreofParma．BloodTransfus201084237-247．20ChenTMTsaiJCBurnoufT．Anoveltechniquecombiningplateletgelskingraftandfibringlueforhealingrecalcitrantlowerextremi-tyulcers．DermatolSurg2010364453-460．2011-04-0204-23。、RhDD。028-68169130·962·2011042404ChinJBloodTransfusionApril2011Vol．24No．04