Meta分析对效应量率的合并方法的研究进展

Meta肖和卫1,2,张顺祥2,谭红专1Meta,(OR)(RR),,MetaMeta;;:R1951:A:10096639(2011)050445032060,Meta[1],1995Beecher[2]Meta;1976Glass[3]Meta,:MetaMeta,,,1991FleissGross[4]Meta,,,Meta,,,,1986Deseminian[5]1987Sacks[6]MetaOR,Meta,[7]1994,ORRR,[8],[9],,,:(2008ZX10002001):1,410078;2:,,:,Email:zhangsx@szcdcnet,,Meta,,Meta,1,,Sutton[10]:P=eyY=(W1Y1+W2Y2+WnYn)(W1+W2+Wn),Y95%CI=Y1961WiYii,Yi=ln(di/qi),diqi;Wii,Wi=1/Vari=1/(1/di+1/qi),VariI2,I2=[(Qdf)/Q]100%,Q,dfI21%~100%,I250%,,=005[11],72,,287%(95%CI:272%~303%),(I2=890%,P0001),2,,,,44520115125ChinPrevMed,May2011,Vol12No595%=p196SpAli[12],,835,,24%(CI:17%~55%)24%(CI:14%~110%)835,21%(CI:04%~54%)30%(CI:03%~319%)[13]Meta,,Q=104285,df=4,P=00001,,MetaOR2842,95%(1329~4354),HBs,,,7654%,6905%[14]Meta,(2=206,P=0195),,Meta,OR67(2=1856,P001),,230%40%,HCV,HCV3,,Batham[15],272,,61:;:,,ELISARPHADIA(Se)(Sp),,P=[P(1Sp)]/[Se(1Sp)],,,,95%=p196Sp,,,Revman42159%(CI:114%~204%)24%(95%CI:22~27%),100%,17,,159%(CI:114%~204%)27%(CI:24%~29%),,,,4,,[16]438,,13,,(%)=(-)/100%=(1-RR)100%,,,,1065TCID50(2=990,P=054),,RR=00495%(CI)(002,007),,1065TCID5096%,95%CI93%~98%,1065TCID5079%,95%CI(71%~85%);1065TCID5090%,95%CI(87%~92%),/RR,RR544620115125ChinPrevMed,May2011,Vol12No5,,,,,,[7]1994P1=r1/n1,P2=r2/n2,Pi=(r1+r2)/(n1+n2),di=p1-p2,d=idiiS2d=ipi(1-pi)(i)2,95%=d196Sd,Cochran[17],wi=n1n2/(n1+n2)[18]9,HBsAg208,38,1820%,01049,95%CI0052~0158,,yi=i+ei[1920],:y=W*iyi/W*i,S2y=(W*i)1,Wi=[1/n1iP1i(1P1i)+1/n2iP2i(1P2i)]1yi,Wi,Wi*,n1in2i,P1iP2iyi95%CI:95%CI=y196/W*[20](Hp),14,00771,95%CI00579~0096,Hp,Hp04210,95%CI03378~05042,Hp,Hp,,,,,,,,[1]RosenthalRMetaanalysis:areview[J]PsychosomMed,1991,53(3):247[2]BeecherHKThepowerfulplacebo[J]JAMA,1955,159(17):1602[3]GlassGVPrimary,secondaryandMetaanalysisofresearch[J]EducatRes,1976,6(5):3[4]FleissJL,GrossAJMetaanalysisinepidemiology[J]JClinEpidemiol,1991,44(2):127139[5]DeseminianR,LairdNMetaanalysisinclinicaltrials[J]ControlledClinTrials,1986,7:177188[6]SacksHSMetaanalysisofrandomizedcontrolledtrial[J]NewEnglJMed,1987,361(8):450[7]Meta[J],1994,28(5):303307[8]Metaanalysis()[J],1994,3(4):220222[9],Metaanalysis()[J],1995,4(1):3840[10]SuttonAJ,AbramsKR,JonesDR,etalMethodsforMetaanalysisinmedicalresearch[M]Chichester,England:JohnWiley&Sons,Ltd,2000[11],,,meta[J](),2010,6(42):304307[12]AliSA,DonahueRM,QureshiH,etalHepatitisBandhepatitisCinPakistan:prevalenceandriskfactors[J]IntJInfectDis,2009,13(1):919[13],,,Meta[J],2005,22(6):359361[14],,19Meta[J],1997,14(1):1012[15]BathamA,NarulaD,TotejaT,etalSystematicReviewandMetaanalysisofPrevalenceofHepatitisBinIndia[J]IndiaPediatr,2007,44(9):663674[16],Meta[J],2008,14(1):16[17]ArmitagePStatisticalmethodsinmedicalresearch[M]Oxford:BlackwellScientificPub,1983:370[18],,,[J],2002,23(9):853855[19],,[M]:,2000:368370[20],,,Meta[J],2003,24(1):5457(:20110303)()44720115125ChinPrevMed,May2011,Vol12No5