mTOR信号通路的生物学功能

·555·040555-07ααα·556··557·β·558·κBκBαβ·559·ár·560·–már·561·TheprogressofstudyonthebiologicalfunctionofmTORpathwayHong-JuChen,YiQu,De-ZhiMuDepartmentofPediatrics,WestChinaSecondUniversityHospital,SichuanUniversity,Chengdu,610041,ChinaAbstractMammaliantargetofrapamycin(mTOR)isanatypicalSer/Thrproteinkinase,whichcanintegrateextracellularsignals,phosphorylateitsdown-streamp70S6kinasessuchasS6K1and4EBP1,toplayrolesingenetranscriptionandproteintranslation.Thusitcanmodulatetheprocessesofcellgrowthandproliferation.mTORisbecomingaresearchfocusduetoitsvariousbiologicalfunctionsassociatedwithproteinsynthesis,immunity,metabolismandmovement,apoptosisandautophagyandsoon.KeywordsmTOR;apoptosis;autophagy;proteinsynthesis