自身免疫性大疱性皮肤病评分系统在天疱疮治疗中的应用-阳艺

40220133[]2012-07-12[]2012-12-20[]1988—[]Tel[phone]-、。[1]。、[2]。10autoimmunebullousskindisorderintensityscoreABSIS。1、[3]。Agarwal[4]pemphigusareaandac-tivityscorePAAS、。Herbst[5]。Harman[6]13、[7]。Saraswat[8]。Mahajan[9]阳艺郭宜青综述周红梅审校（610041）[]、-。、、。。[][]R781.5+9[]A[doi]10.7518/gjkq.2013.02.037TheapplicationofautoimmunebullousskindisordersintensityscoreinthetreatmentofpemphigusYangYi,GuoYiqing,ZhouHongmei.Dept.ofOralMedicine,WestChinaHospitalofStomatology,SichuanUni－versity,Chengdu610041,China[Abstract]Pemphigusisakindofserious,chronicskin-mucosabullousdisorder.Glucocorticoid,asthefirstchoicedrug,couldreducethemortalityofthediseaselargely,whilelong-termusecouldleadtofataladversereaction.Seriesofevaluationsystemhavebeenputforwardbyforeignscholars,whichcontributesignificantlytodiseaseanddrugefficacyassessmentandmonitoring.Autoimmunebullousskindisordersintensityscoresysteminthispaperisarelativelyacceptedsystem,andsomesuggestionsforimprovementwouldbeputforwardaccordingtoourclinicalpractice.[Keywords]pemphigustreatmentautoimmunebullousskindisordersintensityscore273··40220133（下转第278页）。[10]pemphigusdiseaseareaindexPDAI。2ABSIS2007Pfütze[11]ABSIS。2.1皮肤病损评分标准ABSIS=×。“”59%、36%、9%、18%、1%1%。、、=1.5=1=0.5。、、=20%=1.5ABSIS=20×1.5=30212%=1ABSIS=12×1=12。3012。2.2口腔黏膜病损评分标准ABSIS2/。11、、、、、、、10。9=1、=2、=3、=4、=5、=6、=7、=8、=9。=1=0.5=0。、、、、、8=8、7=1×0.5+2×0.5+3×1+4×1+5×1+6×1+7×1+8×1+9×1=43.5ABSIS=8/43.5。2ABSIS=6/23.5。ABSIS。ABSISABSIS。ABSIS[12]。3ABSIS、1ABSIS/“/”。RrangeSsymptomR=8S=43.529349[13]PDAI、。4[1]FernandoSL,BroadfootAJ.Treatmentoptionsforpem-phigusfoliaceus[J].GItalDermatolVenereol,2009,1444363-377.[2]JessopS,KhumaloNP.PemphigusAtreatmentupdate274··40220133!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!（上接第274页）[J].AmJClinDermatol,2008,93147-154.[3]KasperkiewiczM,SchmidtE,ZillikensD.Currentthera-pyofthepemphigusgroup[J].ClinDermatol,2012,30184-94.[4]AgarwalM,WaliaR,KochharAM,etal.PemphigusAreaandActivityScorePAAS—anovelclinicalsco-ringmethodformonitoringofpemphigusvulgarispatients[J].IntJDermatol,1998,372158-160.[5]HerbstA,BystrynJC.Patternsofremissioninpemphi-gusvulgaris[J].JAmAcadDermatol,2000,423422-427.[6]HarmanKE,SeedPT,GratianMJ,etal.Theseverityofcutaneousandoralpemphigusisrelatedtodesmoglein1and3antibodylevels[J].BrJDermatol,2001,1444775-780.[7]SebaratnamDF,MurrellDF.Objectivescoringsystemsfordiseaseactivityinautoimmunebullousdisease[J].DermatolClin,2011,293515-520.[8]SaraswatA,BhushanK,IndiaC.Anewgradingsystemfororalpemphigus[J].IntJDermatol,2003,425413-414.[9]MahajanVK,SharmaNL,SharmaRC,etal.Twelve-yearclinico-therapeuticexperienceinpemphigusAretrospectivestudyof54cases[J].IntJDermatol,2005,4410821-827.[10]MurrellDF,DickS,AhmedAR,etal.Consensusstate-mentondefinitionsofdisease,endpoints,andthera-peuticresponseforpemphigus[J].JAmAcadDermatol,2008,5861043-1046.[11]PfützeM,NiedermeierA,HertlM,etal.IntroducinganovelAutoimmuneBullousSkinDisorderIntensityScoreABSISinpemphigus[J].EurJDermatol,2007,1714-11.[12]DanielBS,HertlM,WerthVP,etal.Severityscoreindexesforblisteringdiseases[J].ClinDermatol,2012,301108-113.[13]CharmanCR,VennAJ,WilliamsHC.MeasurementofbodysurfaceareainvolvementinatopiceczemaAnimpossibletask[J].BrJDermatol,1999,1401109-111.xillofacSurg,1982,40118-22.[18]SchellhasKP,PolleiSR,WilkesCH.PediatricinternalderangementsofthetemporomandibularjointEffectonfacialdevelopment[J].AmJOrthodDentofacialOrthop,1993,104151-59.[19]HoppenreijsTJ,FreihoferHP,StoelingaPJ,etal.Con-dylarremodellingandresorptionafterLeFortandbi-maxillaryosteotomiesinpatientswithanterioropenbite.Aclinicalandradiologicalstudy[J].IntJOralMaxillofacSurg,1998,27281-91.[20]CrawfordJG,StoelingaPJ,BlijdorpPA,etal.StabilityafterreoperationforprogressivecondylarresorptionafterorthognathicsurgeryReportofsevencases[J].JOralMaxillofacSurg,1994,525460-466.[21]HuangYL,PogrelMA,KabanLB.Diagnosisandmana-gementofcondylarresorption[J].JOralMaxillofacSurg,1997,552114-120.[22]TroulisMJ,TayebatyFT,PapadakiM,etal.Condylecto-myandcostochondralgraftreconstructionfortreatmentofactiveidiopathiccondylarresorption[J].JOralMaxi-llofacSurg,2008,66165-72.[23]PadwaBL,MullikenJB,MaghenA,etal.Midfacialgrowthaftercostochondralgraftconstructionofthemandibularramusinhemifacialmicrosomia[J].JOralMaxillofacSurg,1998,562122-128.[24]DelaColetaKE,WolfordLM,Gon觭alvesJR,etal.Ma-xillo-mandibularcounter-clockwiserotationandmandibu-laradvancementwithTMJConceptstotaljointprosthe-sesPart—skeletalanddentalstability[J].IntJOralMaxillofacSurg,2009,382126-138.[25]DelaColetaKE,WolfordLM,Gon觭alvesJR,etal.Ma-xillo-mandibularcounter-clockwiserotationandmandibu-laradvancementwithTMJConceptstotaljointprosthe-sesPart—airwaychangesandstability[J].IntJOralMaxillofacSurg,2009,383228-235.278··