细胞凋亡与肿瘤的发生和治疗-司斌

:430070　,(　、);()　　司　斌　张世明　刘志遐　　,,,,。,,,。,。——(programmedcelldeath,PCD)。,,,,Robert1993“”,,,。、(apoptosis),PCD,Kerr1972,、、[1]。,,DNA。、,,BCL-2,。BCL-21418,B,。BCL-2,。,,,[2]。,BCL-2“”,。,BCL-2[3]。,,,。,,、[4]。StauntonGaffney[5]209(),,、、。p53[6]。p53“”,。DNA,p53,G1,。,p53,。p53,DNAS,,[6]。c-myc,。,c-myc:。,。,,。BCL-2c-myc,“”,,。[7]。c-myc、BCL-2p53。,,,,,[5]。,,,,。、,[1,4,8]。[8],·566·ChinJInternMed,August1997,Vol36,No.8,。　1.:Meyn[9],11。,。TCD50(50%)11。,[4]。,。3-aminobenzamidedibutrylc-AMP,。。,。,,,,、。,p53。,p53。2.:[4],,。,。。,。,,。,,,,。,,——(MDR)。,,。,BCL-22～3。BCL-2,MDR。MDRBCL-2,p53,BCL-2,。3.:[4],T、KNK。T(CTL):。CTL,,。CTL,DNA。。4.:,、,,、。,。。MDR,,。,,BCL-2。、,,,:(1),。(2),。,。(3),,·567·19978368RNA,。(4),、。,,。“”,。,,。1.D'AmicoAV,McKennaWG.Apoptosisandare-investi-gationofthebiologicbasisforcancertherapy.RadiotherOncol,1994,33:3.2.CarsonDA,RibeiroJM.Apoptosisanddisease.Lancet,1993,341:1251.3.HockenberyD,NunezG,MillimanC,etal.Bcl-2isaninnermitochondrialmembraneproteinthatblockspro-grammedcelldeath.Nature,1990,354:334.4.KerrJF,WinterfordCM,HarmonBV.Apoptosis.Itssignificanceincancerandcancertherapy.Cancer,1994,73:2013.5.StauntonMJ,GaffneyEF.Tumortypeisadeterminantofsusceptibilitytoapoptosis.AmJClinPathol,1995,103:300.6.LaneDP.Cancer.p53,guardianofthegenome.Nature,1992,358:15.7.BissonnetteRP,EcheverriF,MahboubiA,etal.Apop-toticcelldeathinducedbyc-mycisinhibitedbybcl-2.Nature,1992,359:552.8.FisherDE.Apoptosisincancertherapy:crossingthethreshold.Cell,1994,78:539.9.MeynRE,StephensLC,VoehringerDW,etal.Bio-chemicalmodulationofradiation-inducedapoptosisinmurinelymphomacells.RadiatRes,1993,136:327.(:1996-07-22　　:1997-01-05)(　　)肝硬化合并布氏菌病一例孙殿兴　齐建民　王淑凤　葛建文　孙晓云　　,58,、、5,12,、21996721。5“”。,/,B,、,“”,,。12,37.0～39.5℃,,,,,8,2400ml。:39℃,,,,3.5cm,,。,62×109/L,,ALT20U/L,(ALB)27.8g/L,(GLB)29.2g/L,(TBil)47.8μmol/L,,11600,44%。:(1);(2)。,,,37.7～:05008239.5℃,40.1g,1,0.45g,1,0.5g,2,8,,14。63,,6。,ALB20.6g/L,TBil75.1μmol/L,,,66ALTTBil,ALB35.5g/L,GLB29.8g/L。　,,。,50%。,,,,。,,。(:1996-10-21　　:1997-04-04)(　)·568·ChinJInternMed,August1997,Vol36,No.8