大数据+SCI29

金华市中心医院ICU章仲恒指的是所涉及的数据量规模巨大到无法通过人工，在合理时间内达到截取、管理、处理、并整理成为人类所能解读的信息。“大数据”时代已经降临，在商业、经济及其他领域中，决策将日益基于数据和分析而作出，而并非基于经验和直觉。-------2012《纽约时报》LeoAnthonyCeli,RogerG.Mark,DavidJ.Stone,andRobertA.Montgomery“BigData”intheIntensiveCareUnit.ClosingtheDataLoop,AmericanJournalofRespiratoryandCriticalCareMedicine,Vol.187,No.11(2013),pp.1157-1160.efficientuseofresearchinvestments.UnethicalGreatergeneralizability(largeregistriesandadministrativedata)Primarydatacollectionistooonerous(5-or10-yrfollow-ups)morepreciseestimateofeffect(largesample)DataQualityTaxonomyoftheQuestionMappingtheQuestiontotheDataBlackN,PayneM:Directoryofclinicaldatabases:Improvingandpromotingtheiruse.QualSafHealthCare2003;12:348–352publicresearcharchiveofdatacollectedfrompatientsinintensivecareunits（30000）Openaccess,freelyavailiable()HighresolutionBethIsraelDeaconessMedicalCenter(Boston)TechnologyprovidedbyMIT.Latestversion:2001-2008Figure1.RelationshipbetweeninitialiCa(upperpanel)andlogittransformedmortalitybyusingLowesssmoothingtechnique.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204:doi/10.1371/journal.pone.0095204Table3.Multivariablelogisticregressioncategorizingcalciumvaluesintointervalsbyusinglinearsplinefunction.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204:doi/10.1371/journal.pone.0095204Table4.Multivariablelogisticregressioncategorizingcalciumvaluesintodesignvariables.ZhangZ,XuX,NiH,DengH(2014)PredictiveValueofIonizedCalciuminCriticallyIllPatients:AnAnalysisofaLargeClinicalDatabaseMIMICII.PLoSONE9(4):e95204.doi:10.1371/journal.pone.0095204:doi/10.1371/journal.pone.0095204Longformatidyearsexincue---------------------------180050000181055001182060000280120001281122000282133000380030000381020000382010001Wideformatidsexinc80inc81inc82ue80ue81ue82-----------------------------------------------105000550060000102120002200330010030300020001000001Multipleimputationtechnique海泰电子病历系统SQL语言集合（）Themed_eventstablecontainsinformationpertainingtothepatient,dosageandannotation.Theadditivestablecontainsinformationrelatedtotheadditiveswhichareincludedwiththedrugadministration.Thea_meddurationstablecontainsinformationaboutthetimeanddurationofthemedicationthed_meditemtablelinkstheothertablestogether.JThoracDis.2013Dec;5(6):730-6.1•RedcelldistributionwidthisassociatedwithhospitalmortalityinunselectedcriticallyillpatientsBMCNephrol.2013Oct28;14:235.2•HigherserumchlorideconcentrationsareassociatedwithacutekidneyinjuryinunselectedcriticallyillpatientsJournalofCriticalCare.2014online3•PlateletindicesarenovelpredictorsofhospitalmortalityinICUpatients大数据是信息时代的标志医疗信息的电子化将带来临床研究的变革利用好现有的信息资源服务于临床研究