免疫学试题A卷及答案

1ThefinalexaminationofmedicalimmunologyforsevenyearstudentsofGrade2003(2005/12/6)PaperA题号一二三四五总分统分人得分得分评卷人I.Explainthefollowingitems(2pointsforeach,18points)1.Lymphocyterecirculation扣分2.CDR扣分3.cytokine扣分4.MHCrestriction扣分25.PRR扣分6.Immunetolerance扣分7.ITAM扣分8.APC扣分9.TI-Ag扣分II.Chooseallcorrectanswers(1pointforeach,15points)得分评卷人No.12345678AnswerNo.910111213Answer31.Whichofthefollowingstatement(s)aboutthespleenis(are)true:A.Itfiltersantigensoutoftheblood.B.LymphaticvesselsdrainingthetissuespacesenterthespleenC.ItcontainsgerminalcentersD.Itfunctionstoremoveoldanddefectiveredbloodcells2.WhichkindsofIgexpressedmainlyonthesurfaceofmatureBcells?A.mIgGB.mIgAC.mIgDD.mIgM3.WhichcanfunctionasC3convertaseinactivationofcomplementsystem?A.C4b2bB.C4b2b3bC.C3bBbD.C3bnBb4.Aboutthecharacteristicsofcytokines,whichofthefollowing(s)is(are)correct?A.OnecytokinecanactondifferentcellsandplaymultiplebiologicaleffectsB.ThecytokineproducedbyonecellonlyactsonneighborcellsC.CombinedwithcorrespondingreceptortoplayroleD.Onecytokinecaninhibitorenhanceeffectsofothercytokine5.WhichofthefollowingmoleculescanstimulateTcellsactivation?A.LPSB.PWMC.ConAD.PHA6.WhatarethefunctionsofBcells?A.produceAbB.secretecytokinesC.killtargetcellsdirectlyD.presentAg7.WhichofthecytokinesaresecretedbyTh1cells?4A.IL-4B.IL-2C.IL-10D.IFN-γ8.WhichofthediseasesbelongtotypeⅢhypersensitivity?A.TransfusionreactionB.ArthusreactionC.ContactdermatitisD.Rheumatoidarthritis9.Whichofthefollowingis(are)correctaboutthecharacteristicsofmemorycells?A.CancomefromeitherBcellorTcellB.CanrespondtoantigenatlowconsentrateeffectivellyC.OnlyexistinHID.Reacttoasecondinvasionofanantigenmorerapidlyandstronger10.Whatabilitiesdoαβ+Tcellsgainaftermaturation?A.self-reactiveB.self-toleranceC.expressfunctionalTCRD.selfMHCrestriction11.Whichofthefollowingsarecorrectstatementsaboutdendriticcells?A.CanstimulatenaïveTcellproliferationB.ExpresshighlevelofMHCclassIImoleculesC.ExpresshighlevelofMHCclassImoleculesD.Maturedendriticcellswithstrongfunctionofantigen-capture12.AboutAICD,whichstatementsarecorrect?A.CanbemediatedbyFasL-FasinteractionB.IsakindofcelldeathofactivatedTcellC.PlayimportantrolesinimmunologicalregulationD.IL-4canpromoteAICD513.Theprocessesofantigen-activatedBcellsdifferentiationingerminalcenterinclude:A.IgClassswitchingB.SomatichypermutationandIgaffinitymaturationC.DifferentiateintoBmD.Apoptosis14.Whichofthefollowingfactorsaffecttheantigenimmunogenecity?A.moleculeweightB.foreignessC.conformationD.chemicalcomposition15.Aboutsomatichypermutation,whichstatementsarecorrect?A.OccursduringBcellsmaturationB.ResultinaffinitymaturationofantibodiesC.MainlyoccursinCDRregionD.CanoccurduringTcellsmaturationⅢ．Answerthefollowingquestionsbriefly(5pointforeach,30points)得分评卷人1.HowcanThelpercellsplayimportantrolesinanantibodymediatedresponse.6扣分2.WhatcellsexpresstheHLAIImolecules?WhatarethefunctionsofHLAIImoleculesonthesecells?扣分3.IfwewanttolabeltheantibodywithenzymeforELISAexperiment,whatpartofantibodydoesenzymeshouldbindto?Why?扣分4.HowdoeffectorspecificCTLskilltumorcells?Whatarethecharacteristicsforthisprocess?7扣分5.HowareendogenousantigensrecognizedbyCD8+Tcells?扣分6.WhatisNeonatehemolysis?Pleasedescribeitsmechanism.扣分IV.Answerfollowingquestion(12points)得分评卷人81.Howtheinnateandadaptiveimmunityactincooperativeandinter-dependentwaystoprotectthehost.?9扣分10ThefinalexaminationofmedicalimmunologyforsevenyearstudentsofGrade2003(2005/12/6)PaperAI.Explainthefollowingitems(2pointsforeach,18points)1.Lymphocyterecirculation:istheprocessbywhichlymphocytescontinuouslymovebetweensitesthroughoutthebody(1)throughbloodandlymphaticvessels,anditiscriticalfortheinitiationandeffectorphasesofimmuneresponses(1).2.CDR:Complementarity-determiningregion(0.5)thethreeHVRofLchainandHchainarebroughttogethertoformantigen-bindingsurface,soHVRisalsocalledCDR(1)3.cytokine:Agroupof(0.5)lowmoleculeweightproteins(0.5)whicharesecretedbyactivatedimmunocytesorsomematrixcells(0.5)andtakeeffectsbybindingcorrespondingreceptoroncells(0.5).4.MHCrestriction:IninteractionofTcellandantigen-presentingcell(APC)ortargetcell(0.5),Tcellnotonlyrecognizesspecificantigenpeptide,butalsorecognizespolymophicresidueofMHCmolecules(0.5).5.Patternrecognitionreceptor(PRR):Thereceptoronmacrophage(0.5)whichcanrecognizeandbindspecificmolecularstructureonsomepathogens,injuredorapoptoticcells(0.5).6.Immunetoleranceaspecificnonreactivity1.0towardsagivenantigen0.5inothercircumstanceisabletoinducecell-mediatedorhumoralimmunity0.5117.ITAMimmunoreceptortyrosine-basedactivationmotif0.5transductactivationsignal1.0composedoftwotyrosineresiduesseparatedbyaround18aminoacid-----whenantigenbinds,thetyrosinebecomephosphorylatedbythereceptorassociatedtyrosinekinasestotransductactivatorysignal0.58.APCcellsthatcancapture（0.5）,processantigen（0.5）,andpresenttheantigenicpeptide/MHCclassIorIImolecules（0.5）toTcells（0.5）arecalledantigen-presentingcells.TheyarealsocalledAcell(Accessorycell).9.TI-Ag(thymusindependentAg):AgwhichcanstimulateBcellstoproduceAb(0.5)withoutthehelpofTcellandMФ(0.5).II.Choos