DBD等离子体制备类2PEO生物功能薄膜及其生物相容性研究

:2007O10O24:(10475010);(kf060201):(1981-),,,,,:,,DBD2PEO1,1,1,2(1.,102600;2.,100069):(DBD)2PEO;,2PEO,:DBD2PEO,2PEO,:;2PEO;;:TB34:A:1001-3563(2008)01-0004-03StudyofDBDPlasmaPolymerizationPEO2likeFunctionalCoatingsanditsBiocompatibilityPropertiesXIEFen2yan1,HUWen2juan1,CHENQiang1,WENGJing2(1.BeijingInstituteofGraphicCommunication,Beijing102600,China;2.CapitalMedicalUniversity,Beijing100069,China)Abstract:Theinfluenceofplasmaparameterssuchasdischargepower,workpressure,andelectrodegapaswellasdischargefrequencyonthechemicalcomponent,surfacepropertiesandbiocompatibilityofthePEO2likecoatingwerestudiedbywatercontactangle(WCA)measurement,Fourier2transforminfraredspectroscopy(FT2IR),X2rayphotoelectronspectroscopy(XPS),andatomicforcemicroscopy(AFM).Invitrocellcultureandtheadsorptionthebloodplateletwerealsocarriedout,whichthecelladsorptionandmorphologywereacquiredwithaphasecontrastmicroscope.TheresultsshowedthatDBDplasmacanpolymerizeanexcellentPEO2likecoating,andcoatingscaneffectivelyreducetheadsorptionofbloodplateletandpreventproteinadhesion.Keywords:dielectricbarrierdischarge(DBD);PEO2like;functionalcoating;celladhesionDBD,,DBD[1][2],[3-4]DBD,/,,[5]DLC,,DLCSP3/SP2,DLC,[6],(PEO),PEO,;PEO,,,[7-8],DBDPEO,,,DBDCH2CH2O(ethyl2eneoxideEO)(EGDME)-PEO[9-10],12PEO4PACKAGINGENGINEERINGVol.29No.12008.01©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(250mm200mm);73mm,,1mm;410mm,,(CTP-2000K,)40100kHz,03,500W11;2;3;4;5;6;7;8;950;10;11;12;131Fig.1Theschematicdiagramoftheexperimentaldevice:20Pa,50Pa,15W(KBr)10min;20Pa,,;,,,;20min,,5min,:5min,,XPS(WCA)JY-82(),;(FTIR)FT2IR-8400;(AFM)CSPM3000()20min,,372h,3,,22.1FTIRXPS2aDBDCH2CH2O1106cm-1,COC,2bCOC1130cm-1,2920cm-12870cm-1CH2asC-HsC-H2PEO,2DBD-PEOFig.2FTIRspectraofmonomerandDBDplasmapolymerizedPEO-likecoatings,EODBD,,(Te110eV)3a1110cm-1COC800Pa,1460cm-1CH2O800Pa1200Pa28002900cm-1CH2,,FTIRDBD,3DBD-PEOFig.3TheFTIRspectraofDBDplasmapolymerizedPEO-likecoatingsondifferentworkingpressureanddischargefrequencies3b,1110cm-1COC:,DBD,,DBD[11],-PEO,DBD2PEOEO,XPSC,O2PEOXPS4,EGDME/Ar,O/C0.8,2PEO;C1sCC(285eV),CO(287eV)C=O(289eV)3,CO5DBD-PEO©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[10,12]3DBD-PEO2PEO2PEO,DBD2PEO,2PEOEO:[1],.[J].,2003(4):7-10.[2],,,.[J].,2005,26(2):12-13.[3].[M].:,1993.[4].[M],:.[5]JANGJ,KIMJG,KOHSO,etal.EffectofHydrogenRadicalAn2nealingonElectricalPropertiesofAmorphousSilicon[J].MatResSocSympProc,1991,219:775-780.[6],,.DLC[J].,2005,36(4):555-558.[7]SHENM,MARTINSONL,WAGNERMS.PEO-likePlasmaPol2ymerizedTetraglymeSurfaceInteractionswithLeukocytesandPro2teins:inVitroandinVivoStudies[J].BiomaterSciPolymEd,2002,13(4):367-90.[8]LOPENZGP,RATNERBD,TIDWELLCD,etal.GlowDis2chargePlasmaDepositionofTetraethyleneGlycolDimethyletherforFouling-resistantBiomaterialSurfaces[J].JBiomedMatRes,1992,(26):415.[9]WUYJ,TIMMONSRB,JENJS,etal.Non2foulingSurfacePro2ducedbyGasPhasePulsedPlasmaPolymerizationofanUltraLowMolecularWeightEthyleneOxideContainingMonomer[J].CollandSurf,B:Bioint,2000,(18):235.[10]GRISTINAR,SARDELLAE,DETOMASOL,etal.FibroblastandKerationcyteBehaviouronSubstratesPlasma2patteringwithFoulingandNon2foulingDomains[J].EuropeanCellsandMaterials,2002,4(Suppl2):94-95.[11],,,..,2004,(2):68-71.[12]YOUNGGunKo,YOUNGHaKim,KIDongPark,etal.ImmobilizationofPoly(ethyleneglycol)oritsSulfonateontoPolymerSurfacesbyOzoneOxidation[J].Biomaterials,2001,(22):2115-2123.6PACKAGINGENGINEERINGVol.29No.12008.01©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.