工业生物技术发展状况分析及前景展望

20095ChinaBasicScience8,100084:200928225:200929222:,,[e-mail],2000,,,::TQ464:A:100922412(2009)05200082061.,,,[1],,,,[2],,,,,(OECD),2030,35%;,39%(36%25%)[3]2008,6.58,30%,(McKinsey&Co),,20129%,,,20076%,100020121530[4],,203030%,2.5,973,,2003,,,©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(20062020),,30004000,70008000,202020000[5],(80%85%),10,,,,,,,,204060,20,,1982,;1996,;2000,,,[6]21,:,RNA;,[7],,,,,,,,[8][911]:(1),,,,(2),,(3),,(4),(5),,(),,,[5,12,13](DOE)20,DOE,203025%©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(BBSRC)10,,4,;,OECD1501.2003,973,6,()973,,,973,,,,,8632006863,36(31)83,,3,20,,2007,(),,,973,,2.10973,,;©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(203);504;30;5;1;1;190;973,,;,,;100,1.2;,90%;D2,A;(PHAPBS),;370m3,,[14,15]1.,,(fromgenometoproduct),()(),[16,17]:(1)(2),()();,,;(3),,,,,(4),,,,(5),;,();(6),,,2,,,(7)©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.()(1)13.OECD,,,,,,,:(1),,(2),,(3);973863;;,,,[1]HermannBG,BlokK,PatelMK.Producingbio2basedbulkchemicalsusingindustrialbiotechnologysavesenergyandcombatsclimatechange.EnvironmentalScience&Technology,2007,41(22):79157921[2]OrganizationforEconomicCooperationandDevelopment.Biotech2nologyforCleanIndustrialProductsandProcesses:TowardsIndus2trialSustainability.Paris:OECD2report,1998[3]..,2005[4]:.,200923224,006[5]2008.:,2009[6].,200629229,008[7],.,20092528,B02[8].,200824221,A02[9],,,,..,2008,59(8):18841893[10]RajniHK,UlrikaT,LindaG,etal.Industrialbiotechnologyfortheproductionofbio2basedchemicals:acradle2to2graveperspec2tive.TrendsinBiotechnology,2007,25(3):119124[11]PatelM,DornburgV,HsingB,etal.MediumandLong2termOp2portunitiesandRisksoftheBiotechnologicalProductionofBulkChemicalsfromRenewableResources:ThePotentialofWhiteBio2technology.Utrecht:UtrechtUniversity,2006:12184[12]MauriceL.IndustrialbiotechnologytakesoffinEurope.ScienceProgress,2008,91(Pt1):3964[13]CamilleB.SusChemindustrialbiotechnology22potentialsandchal2lengesinindustrialbiotechinEurope.ChemSusChem,2008,1(8/9):773774[14],..,2007,22(3):216222[15],,,,,..,2004,55(12):1950©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[16]ZengAP.Fromsystemsbiologytobiosystemsengineeringforindus2trialbiotechnology.JournalofBiotechnology,2008,136(1):S18S19[17]WohlgemuthR.Thelocksandkeystoindustrialbiotechnology.NewBiotechnology,2009,25(4):204213CurrentStatusoftheDevelopmentandFutureTrendsofIndustrialBiotechnologyCaoZhuan,ChenBiqiangDepartmentofChemicalEngineering,TsinghuaUniversity,Beijing100084Industrialbiotechnologycanmakeasignificantcontributiontosolvingthemajornationaldemandsandleadingthedevelopmentofmodernbio2economy.Thispaperintroducedthebackgroundandcharacteristicsofmodernindustrialbiotechnology.TheprocessandtrendofindustrialbiotechnologyinChinawerereviewedandthemeasuresofdevelopingtheindustrialbiotechnologyofothercountrieswerealsoanalyzed.Furthermore,thisreviewgaveadetailedanalysisofmajorbasicscienceissuesbasedonthecurrentdevelopmentsofindustrialbiotechnology.Somesuggestionsforindustrialbiotech2nologydevelopmentinChinaweregiven.Keywords:industrialbiotechnology;bio2economy;de2velopment(31)[11]DeckwerWD,JahnD,HemperD,ZengAP.Systembiologyap2proachestobioprocessdevelopment.EngineeringinLifeSciences,2006,6:455469SystemsBioprocessEngineering:NewInsightsintotheOptimizationandScale2upofIndustrialFer2mentationProcessesZhangSiliangStateKeyLaboratoryofBioreactorEngineering,EastChinaUniversityofScienceandTechnology,Shanghai200237Thecurrentstrategiesforindustrialbioprocessopti2mizationandscale2upwerepresentedfirstlybyseveralpracticalexamples.Thentheinteractionsbetweenenvi2ronmentsinabioreactorandthemetabolismofcellswerediscussedindetailanditwasconcludedthattheenviromeshouldbeacrucialelementtobeconsideredinthestudyofbioprocessinthecontextofsystemsbiol2ogy.Finallysystemsbioprocessengineering,anewstrategyfortheoptimizationandscale2upofindustrialfermentationprocesses,wasputforwardbasedontheintegratedanalysisandutilizationofallinformationcol2lectedfromoutsideandinsidecellsinabioreactor.Keywords:bioreactor;bioprocessoptimization;sys2temsbiology;bioprocessscale2up;envirome;systemsbioprocessengineering©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.