您好,欢迎访问三七文档
当前位置:首页 > 行业资料 > 其它行业文档 > 微生物胞外多糖生物合成研究进展
PharmaceuticalBiotechnology200296369~373*100050EPSsEPSsEPSsEPSsQ936A1005-8915200206-0369-05LPSO-CPSExopolysaccha-rideEPSEPSEPSs1EPSs12EPSsEPSsEPSsXanthomonascampestrisPv.CampestrisxanthanSphingomonasSphingansgellanwellanrhamsansphinganS-88AcetobacterxylinumAcetan34LacticacidbacterialLABStreptococussalivariusssp.ThermophilusS.ThermophiluS.ThermophilusEPSEPS5EPSEPSsGovenPseudomonasaeruginosaalginate6AcetobacterxylinumG-β-D-BioFill1-3-β-D-7StreptococcusequiStreptococcuszooepidermicus4LABEPSsEPSs8~112EPSs963*2002-01-238632001AA2140911969*10005Tel010-63153320CPSEPSsEPSsEPSsAcetobacterPseudomonasSphingomnasStreptococcusLactococcusLactobacil-lus12Fig1ProposedpathwayforxanthangumsynthesisEPSsLPSO-CPSGlycosyltransferaseGTF1314EPSLactococcuslactisNIZOB40EPS2:2:1:115UDP-UDP-dTDP-EPSEPS16xanthan3EPSsXanthan1GumDUDP-glucoseGumMGumHGumKGumIGumFGumGGumLxanthanGumBGumCGumE3EPSsmRNA17~19EPSsG-EPSsxanthanacetansphinganS-88G+LABEPSs2xanthanGumXanthomonascampestrispv.Campestris16kbgumBCDEFGHIJKLM3SphingomonasstrainS88sphinganS-8829kusphinganS-8820LABEPSsLABEPSsLABL.lactissubsp.cremorisLactococcuslactissubsp.lactisEPSLABS.thermophilusEPSEPSLactococcuslactisstrainNIZOB40EPS40ku14epsABCDEFGHIJK12kuepsEPSEpsDGTFGTFG+GTFsEpsD-1-UDP-EpsEEpsFUDP-EpsGUDP-EpsJEPS0739621~23epsEpsREpsAEpsBEpsIEpsKEpsDEpsEEpsFEpsGEpsFFig2GeneclustersinvolvedinEPSbiosynthesisT916EPSStreptococcusthermophilusSfi615.25kuDNA1514.52epsA-epsM13EPS2413424epsEepsFepsGandepsIEpsEEPSEpsGα-N-β-EPSGalactoseGalGlucoseGlcN-N-acetylgalactosamineGalNAcepsFepsIβ-13-EpsEEpsFEpsGα-α-epsCHepsDepsKepsMepsJEPSepsA25N.meningitidisCPS264EPSsacetylpyruvylsuccinylsulphatephoshateEPSsRamos27LactococcusalctisEPSEPS+EPS-EPS6-EPSEPSEPSsEPSsEPSsEPSsEPSsEPSsEPSs28Acetobacterxylimum173acetan29EPSsL.lactisLactobacillussakeo-1EPSEPSS.thermophilusSfi6epsL.lactisMG1363EPSN-L.lactisUDP-N-N-25SphingomonasEPSEPSsEPSsX.campestrisEPSsLAB1LeighJACoplinDL.Exopolysaccharidesinphant-bacterialinterac-tionsJ.AnnuRevMicrobiol199246307.2WhitfieldCValvanoMA.Biosynthesisandexpressionofcell-surfacepolysaccharidesinGram-negativebacterialJ.AdvMicrobialPhysi-ol199335136.3BeckerAKatzenFPuhlerAetal.Xanthangumbiosynthesisandapplicationabiochemical/geneticperspectiveJ.ApplMicrobiolBiotechnol199850145.4SutherlandIW.NovelandestablishedapplicationsofmicrobialpolysaccharidesJ.TrendsBiotechnol19981641.5GriffinAMMorrisVJGassonMJ.ThecpsABCDEgenesinvolvedinpolysaccharideproducductioninStreptomycessalivariusssp.ther-mophilusstrainNCBF2393J.Gene199618323.6GovenJRWDereticV.MicrobialPathogenesisincysicfibrosismu-coldpseudomonasaeruginosaandBurkhoderiacepaciaJ.MicrobiolRev199660539.7KulickeWMLettauAIThielkingH.Correlationbetweenimmuno-logicalactivitymolarmassandmolecularstructureofdifferent13-beta-D-glucansJ.CarbohydrRes1997297135.8KitazawaHTobaTItohTetal.AntitumoralactivityofslimeformingencapsulatedLactococcuslactissubsp.cremorisisolatedfromScandinavianropysourmick'viili'J.AnimSciTechnol199162277.9KitazawaHTobaTTomiokaYetal.IFN-andLI-1αproductioninmacrophagesstiumlatedwithphosphopolisaccharidephoducedbyLac-tococcuslactisssp.cremorisJ.IntJfoodMicrobiol19963199.10KitazawaHHarataTUemuraJetal.Phosphategrouprequire-mentformitogenicactivationoflymphocytesbyanextracellularphos-phopolisaccharidefromLactobacillusdelbrüeckilssp.bulgaricusJ.IntJFoodMicrobiol199840169.11NakajimaHSuzukiYKaizuHetal.Cholesteroi-lowingactivityofropyfermentedmilkJ.JFoodSci1992571327.12VanKranenburgRBoelsICKleerebezemMetal.GeneticsandengineeringofmicrobialexopolysaccharidesforfoodapproachfortheproductionofexistingandpolysaccharidesJ.CurrentOpinioninBiotechnology199910498.13SutherlandIW.BiosynthesisandcompositionofGram-negativebacte-rialextracellularandwallpolysaccharideJ.AnnuRevMicrobiol198539243.14WhiftieldCValvanoMA.BiosynthesisandexpressionofcellsurfacepolysaccharidinGram-negativebacterialJ.AdvMicrobialPhysi-ol199335136.15VanKranenburgRMaruggJDVanSwamⅡetal.Molecularcharacterizationoftheplasmid-encodedepsgeneclusteressentialforexopolysaccharidebiosynthesisinLactococcuslactisJ.MolMicro-biol199724387.16CerningMJ.Exocellularpolysaccharideproducedbylactisacidbacte-riaJ.FEMSMicrobiolRev199087113.17MoronaJKMoronaRPatonJC.Characterizationofthelocusen-codingtheStreptomycespneumoniaetype19FcapsularpolysaccharidebiosyntheticpathwayJ.MolMicrobiol199723751.18MuaozRMollerachMLbpezRetal.Molecularorganizationofthegenesrequiredforthesynthesisoftype1capsularpolysaccharideofStreptomycespneumoniatformationofthebinaryencapsulatedpneumococciandidentificationofcryticDTDP-rhamnosebiosynthesisgenesJ.MolMicrobiol19972579.19SauSSunJLeeCY.Molecularcharacterizationandtranscriptionalanalysisoftype1capsulegenesinStaphylococcusaureusJ.JBacteriol19971791614.20YamazakiMThorneLMikolajczakMetal.Linkageofgeneses-sentialforsynthesisofapolysaacharidecapsuleinSphingomonasstrainS88J.JBacteriol19961782676.21VanKranenburgRVanSwamⅡMaruggJDetal.Exopolysac-charidebiosynthesisinLactococcuslactisNIcdB40functionanaly-sisotheglycosyltransferasegenesinvolvedinsynthesisofthepolysac-charidebackboneJ.JBacterio
本文标题:微生物胞外多糖生物合成研究进展
链接地址:https://www.777doc.com/doc-288274 .html