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1,1,2,1(1.,150030;2.,150030):,,,,:;;:Q51:A:16717236(2010)10003504(celladhesionmolecule,CAM),,,,,(extracellularmatrix,ECM)5:(integrinfamily);(immunoglobulinsuperfamily,IGSF);!(selectinfamily);∀(Ca2+dependentcelladhesionmoleculefamily)Cadherin;#(hyaladherin)(integrin)1,,3ECM249,24(Gaudreault2007)∃,700~110030~50:20100407:(1985-),,,,::,,Email:qingzhangli@hotmail.com:(2006BAD04A0309);(CXT00511),(actinin)(talin)(vinculin),Rap1%%RIAM,,(Banno,2008)2,,,,(Leqate,2009)2.1整合素在细胞黏附中的作用,,--(ArgGlyArp,RGD),ECM(Auzzas,2005),,RGD,,ECM,ECMVonWillebrand(vitronection)(tenascin),GPRCS21CS25P1P2&35&20103710,(Makrilia,2009)N,KXGFFKR,1,1(CD29),CD29(,2009),ECM,ECM,,CD29,,CD29,:;;!,CD29(,2009)Lee(2006),21(IGF21)PI32K/AKT1;2,;3,,v3ECM(FN)(VN)(LN)(col),,(),;4,64,Dahlawi(2006),,6,6,,(Chilcoat,2008),∋Nature(,,,ShigellaOspE()%%;,,OspE(Minsoo,2009)2.2整合素在细胞内信号转导中的作用,,(focaladhesionkinase,FAK),125,FAK,FAK,FAK,FAK,C(Berman,2000),,,,(Dalen,2002),1(JinMin,2009),115161(Koumouridis,2002)v3,v3,(Luo,2006)v3:%,;(McCallCulbreath,2008)v3(),,&36&20103710,,,,(Alison,2006),v3(,2009),Kimura(2006)FN51,Rac1,Rac1Rho,,,FN51v3Hattori(2007),PHSRN,PHSRNFN(RGD),PHSRNFN(),PHSRNFN;,,PHSRNFN,VEGFA,91;v3v5,91VEGFA121,VEGFA165121;91VEGFCVEGFD,,91(Vlahakis,2007),(,2009)v3v3:v3,(bonesialoprotein,BSP),H,,;v3BSPRGD(ArgGlyAsp),,(,2009),,(STAT),(Tang,2010)3,,,;,,(Cheresh,2010),(endothelial)PEselectin;Selectin(neutrophil),%,%,trapping,(),IgSF(ICAM),,,,,4:,,,,,,,,,,,,,,,(,2009)4,,,,&37&20103710,,,,,,,,1,.[J].,2009,3(5):313~315.2,,,.[J].,2009,36(8):85~88.3,,.[J].,2009,27(6):525~529.4,.1[J].,2009,29(15):1938~1940.5,,.[J].,2009,29(3):192~196.6,,.v3[J].,2009,45(9):46~48.7AlisonB,NicolaGA,StuartC,etal.SpecificityoftheVP1GHloopoffootandmouthdiseasevirusforvintegrin[J].JVirol,2006,80(19):9798~9810.8AuzzasL,CasiraghiG,RassuG,etal.GraftingaminocyclopentanecarboxylicacidsontotheRGDtripeptidesequencegenerateslownamomloaralphaVbeta3/alphaVbeta5integrindualbinders[J].MedChem,2005,48:7675~7687.9BannoA,GinsbergMH.Integrinactivation[J].BiochemSoctrans,2008,36(Pt2):229~234.10BermanAE,KozlovaN.Integrin:structureandfunction[J].MemberCellBiology,2000,13(2):207~244.11ChereshDA,DesgrosellierJS.Integrinincancerbiologicalimplicationsandtherapeuticopportunities[J].NatRevCancer,2010,10(1):9~22.12ChilcoatCD,JonesSL,ShariefY,etal.TonicproteinkinaseAactivitymaintainsinactiveintegrinsinunstimulatedneutrophilsbyreducingmyosinlightchainphosphorylation:roleofmyosinlightchainkinaseandRhokinase[J].JLeukocBiol,2008,83(4):964~971.13DahlawiSA,EslamiA,HakkinenL,etal.ThealphaVbeta6integrinplaysaroleincompromisedepidermalwoundhealing[J].WoundRepairRegen,2006,14(3):289~297.14DalenH,LarsenTH,SaetersdalT.The1integrinsubunitisnotaspecificcomponentofthecostameredomaininhumanmyocardialcells[J].HistochemJ,2002,34(6~7):323~329.15GaudreaultM,VigneaultF,ZanioloK,etal.Contralofintegringenesintheeye[J].ProgRetinEyeRes,2007,26(2):99~161.16HattoriA,KimuraK,UsuiY,etal.Stimulationofcornealepithelialmigrationbyasyntheticpeptide(PHSRN)correspondingtothesecondcellbindingsiteoffibronectin[J].InvestOphthalmolVisScience,2007,48(3):1110~1118.17KimuraK,KawamotoK,TeranishiS,etal.Roleofrac1infibronectininducedadhesionandmotilityofhumancornealepithelialcells[J].InvestOphthalmolVisScience,2006,47(10):4323~4329.18KoumouridisA,PriftiiS,ZourabY,etal.Roleofintegrinsininvasionofendometrialcancercelllines[J].GynecolOncol,2002,84(1):12~20.19LeeHK,LeeJH,KimM,etal.Insulinlikegrowthfactor1inducesmigrationandexpressionoflaminin5inculturedhumancornealepithelialcell[J].InvestOphthalmolVisScience,2006,47(3):873~882.20LeqateKR,MoserM,etal.Thetailofintegrins,talinandkindlins[J].Science,2009,324(5929):895~899.21LuoBH,TimothyAS.Integrinstructuresandconformationasignaling[J].CurrentOpinioninCellBiology,2006,18(5):579~586.22MakriliaN,KolliasA,etal.Celladhesionmolecules:roleandclinicalsignificanceincancer[J].ConcerInvest,2009,27(10):1023~1037.23McCallCulbreathKD,ZutterMM.Clooagenreceptorintegrins:risingtothechallenge[J].CurrentDrugTargets,2008,9(2):139~149.24MinsooK,MichinagaO,etal.Bacteriahijackintegrinlinkedkinasetostablizefocaladhesionandblockcelldetachment[J].Nature,2009,459(3):578~582.25NamJM,YoonsunC,etal.1integrintargetingtoenhanceradiationtherapy[J].InternationalJournalofRadiationBiology,2009,85(11):923~928.26TangJZ,ZuoZH,etal.SignaltransducerandactivatoroftransriptionSTAT5AandSTAT5Bdiffererntiallyregulatehumanmammarycarcinomacellbehavior[J].TheEndocrineSociety,2010,151(1):43~55.27VlahakisNE,YoungBA,AtakilitA,etal.Intrgrinalpha9/beta1directlybindstovascularendothelialgrowthfactor(VEGF)AandcontributestoVEGFAinducedangiogenesis[J].BiologyChem,2007,282(20):15187~15196.AdvancesinBiologicalFunctionofIntegrinsTONGJinjin1,QUBo1,2,LIQingzhang1(1.KeyLaboratoryofDairyScienceofEducationMinistry,NortheastAgriculturalUniversity,Harbin150030,China;2.LifeScienceandBiotechnologyResearchCenter,NortheastAgriculturalUniversity,Harbin150030,China)&38&201037101,1,2,2,1,1,1(1.,530001;2.,530003):(TephrosiacanadidaDC.),,20%40%60%,:,,;;!(P0.05);∀40%60%,,:;;;;:S859.82:B:16717236
本文标题:整合素生物学功能的研究进展
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