肠道菌群失调与结肠癌发生发展之间关系的研究进展-王生

网络出版时间:2014－7－1016:51网络出版地址:．cnki．net/kcms/doi/10．3969/j．issn．1001－1978．2014．08．003．html121241212123123(1．中国医药工业研究总院，上海200040;2．上海医药工业研究院创新药物与制药工艺国家重点实验室，上海200437;3．上海市生物物质成药性评价专业技术服务中心，上海200437;4．第四军医大学西京消化病医院，陕西西安710032)doi10．3969/j．issn．1001－1978．2014．08．003A1001－1978201408－1045－05Ｒ-05Ｒ322.45Ｒ378.2Ｒ589.2Ｒ735.350.22、、。、、。、。。、。[e-mail][e-mail][e-mail]2007NIHHumanMicrobi-omeProjectHMP2008“”MetagenomicsoftheHumanIntestinalTractMetaHIT。、、1。、、、、。、。、2。。、、。、。。、。1、。、Tab1、Tab2。LPS3。Tab1Mainprobioticsinintestinal4Nissle1．1·5401·中国药理学通报ChinesePharmacologicalBulletin2014Aug;30(8):1045～9Tab2Mainpathogenicbacteriainintestinal5、、、。。Hekmatdoost6。7。。Turnbaugh8。Larsen9β-。Edlund10。1．2。、、、。11sIgA。12CINF-C、4IL-4、ATNF-A、PAF、。2。Scanlan13。Sobhani。。、、、、、、、、、。、。、、、。。14。。、。3。、①②。3．1。15。。、Wnt、Notch、TGF-βNF-κBSTAT3MAPKAkt/PKB16。17。TollTLＲsNodNod-likereceptors、、、、、·6401·中国药理学通报ChinesePharmacologicalBulletin2014Aug;30(8)18。3．2。、、、、19。Chan20、、、、、、、。、。3、ＲOS、。。DNA、、、、、DNA21。DNAＲOS22。。7aDNAＲOS23。4、、。。25%～50%24。3743、LGGBB12TIL-2IFN-γ25。、HT-29、SW480、Caco226。Lederberg“”27。。、。、、28。。ColeyColey。。1HooperLVLittmanDＲMacphersonAJ．InteractionsbetweenthemicrobiotaandtheimmunesystemJ．Science201233660861268－73．2MaXHuaJLiZ．Probioticsimprovehighfatdiet-inducedhe-paticsteatosisandinsulinresistancebyincreasinghepaticNKTcellsJ．JHepatol2008495821－30．3．J．中国药理学通报201329121644－7．3WuXFLianNQLuCFetal．ＲesearchprogressoneffectofintestinalfloraonchronicliverdiseasesJ．ChinPharmacolBull201329121644－7．4ParvezSMalikKAAhKangSKimHY．ProbioticsandtheirfermentedfoodproductsarebeneficialforhealthJ．JAppliedMi-crobiol200610061171－85．5ZhaoYYeMQChaoQGetal．Simultaneousdetectionofmulti-food-bornepathogenicbacteriabasedonfunctionalizedquantumdotscoupledwithimmunomagneticseparationinfoodsamplesJ．JAgricultuFoodChem2009572517－24．6HekmatdoostAFeizabadiMMDjazayeryAetal．TheeffectofdietaryoilsoncecalmicroflorainexperimentalcolitisinmiceJ．IndianJGastroenterol2008275186－9．·7401·中国药理学通报ChinesePharmacologicalBulletin2014Aug;30(8)7deLaSerreCBEllisCLLeeJetal．Propensitytohighfatdiet－inducedobesityinratsisassociatedwithchangesinthegutmi-crobiotaandgutinflammationJ．AmJPhysiolGastrointestLiverPhysiol20102992G440－8．8TurnbaughPJHamadyMYatsunenkoTetal．Acoregutmi-crobiomeinobeseandleantwinsJ．Nature20094577228480－4．9LarsenNVogensenFKvandenBergFWetal．Gutmicrobiotainhumanadultswithtype2diabetesdiffersfromnon-diabetica-dultsJ．PLoSOne201052e9085．10JernbergCLfmarkSEdlundCetal．Long－termimpactsofantibioticexposureonthehumanintestinalmicrobiotaJ．Micro-biology2010156113216－23．11ChoudhryMAＲanaSNKavanaughMJ．ImpairedintestinalimmunityandbarrierfunctionacauseforenhancedbacterialtranslocationinalcoholintoxicationandburninjuryJ．Alcohol2004333199－208．12DingLALiJS．GutindiseasesphysiologicalelementsandtheirclinicalsignificanceJ．WorldJGastroenterol20039112385－9．13ScanlanPDShanahanFCluneYetal．Culture-independenta-nalysisofthegutmicrobiotaincolorectalcancerandpolyposisJ．EnvironMicrobiol2008103789－98．14Icaza-ChávezME．GutmicrobiotainhealthanddiseaseJ．ＲevGastroenterolMex2013784240－8．15SinghNGuravASivaprakasamSetal．Activationofgpr109areceptorforniacinandthecommensalmetabolitebutyratesup-pressescolonicinflammationandcarcinogenesisJ．Immunity2014401128－39．16FukataMAbreuMT．PathogenrecognitionreceptorscancerandinflammationinthegutJ．CurrOpinPharmacol200996680－7．17ＲubinDCShakerALevinMS．Chronicintestinalinflamma-tioninflammatoryboweldiseaseandcolitis-associatedcoloncancerJ．FrontImmunol201283107．18KinnebrewMAPamerEG．InnateimmunesignalingindefenseagainstintestinalmicrobesJ．ImmunolＲev20122451113－31．19ScanlanPDShanahanFCluneYetal．Culture-independenta-nalysisofthegutmicrobiotaincolorectalcancerandpolyposisJ．EnvironMicrobiol2008105789－98．20ChanECKohPKMalMetal．Metabolicprofilingofhumancolorectalcancerusinghigh-resolutionmagicanglespinningnuclearmagneticresonanceHＲ-MASNMＲspectroscopyandgaschroma-tographymassspectrometryGC/MSJ．JProteomeＲes200981352－61．21TjalsmaHSchller-GuinardMLasonderEetal．Profilingthehumoralimmuneresponseincoloncancerpatientsdiagnosticanti-gensfromStreptococcusbovisJ．IntJCancer200611992127－35．22HandaONaitoYYoshikawaT．Ｒedoxbiologyandgastriccarci-nogenesistheroleofHelicobacterpyloriJ．ＲedoxＲep20111611－7．23BernsteinCHolubecHBhattacharyyaAKetal．Carcinogenic-ityofdeoxycholateasecondarybileacidJ．ArchToxicol2011858863－71．24YazawaKFujimoriMNakamuraTetal．Bifidobacteriumlon-gumasadeliverysystemforgenetherapyofchemicallyinducedratmammarytumorsJ．BreastCancerＲesTreat2001662165－70．25．J．中国微生态学杂志2011323274－6．25KuangXYZhangQWuJZetal．MechanismandapplicationofprobioticsintumorpreventionandtherapyJ．ChinJMicro-ecol2011323274－6．26ZhuYMichelleLuoTJobinCetal．Gutmicrobiotaandprobi-oticsincolontumorigenesisJ．CancerLett20113092119－27．27OmerTurkiMamdohErshidatAymanSulimanMazahreh．Probiot-icsbacteriainfermenteddairyproductsJ．PakistanJNutr2009871107－13．28StritzkerJWeibelSHillPJetal．Tumor-specificcolonizationtissuedistr