镉对人体健康的危害效应及其机理研究进展

1,1,2(1.,532400;2.,530005);;;X838A0517-6611(2007)09-02528-04ReviewontheToxicologicalEffectandtheMechanismofCadmiumtoHumanHealthHUANGQiu2chanetal(DepartmentofChemistryandLifeScience,NanningTeachersCollege,Longzhou,Guangxi532400)AbstractInthisreviewthetoxicityanditsmechanismofcadmiumtothehumanhealthwerebesummarized.Thetoxicologicaleffectsandthetoxigenicitymechanismofthecadmiumtolung,bone,kidney,bloodvessel,immunitysystem,descendiblityandliverandprocreationsystemwereexplained.KeywordsCadmium;Humanhealth;Toxicologicaleffect;Mechanism(Cd),(1035),,,2.2t[1]0.3mg/kg,50g/m3,50g/m33,3040mg,33%,14%,2%,0.13%[2],,,,,30,,,1,,,,50,2030g/kg[3],,1.1,410h,,,(),,[4],(30360048);(1971-),,,,,2006212229[5]3,3,[6],IgCIgM,OKT4OKT8,Tn/Ts,T,,,[7],(16HBE),1.2,1030,,,,[8],,(UCd)(BCd)(BCd),(BMD)[9][10]20,BMD(UCd);20,,,,[11],,,UCd95%(BMDL)BMDL,,,,VitD,,,[12]1.3,,1976,100300g/g,200g/g[13],,JournalofAnhuiAgri.Sci.2007,35(9):2528-253188%Scott,,[12],,[14][15],(UCd)N222D2(UNAG)22(UBMG)(URBP)(UALB),,UN2AG,,UNAG,UALB,UCdUBMG,[16-17][18],,UNAG,,Ca2+2Mg2+2ATPase,,,,[19],,anti2MTAb[20](HEK239T),,(LDH),c,N22L2L(NAC),,21(HO21),[21-23],,1.41966Carroll,,1981Revis,,,[24](),[25](GSH2PX),,(ANP)[26-27],[28];(RBC)(SOD),RBC[29],;,[30][31],,(AP)0(APA)(Vmax),(APD)APAPAVmax,APD,Na+AP2Ca2+,K+[32],,,,[33]1.5[34],25mol/L(NK),NK,TB[35](PBL)(SCE)[36],PBLMT[37],HL27702,HL27702S[38]1.6[39],,,,,(),SDNADNA,DNA82,DNAc2mycc2fosc2jun,C,,[40]DNA;,DNA[41][42],,CdC12H2O2DNA,DNA1.7,,,[43],,[44]Ca2+[45]1.8[46],,,[47],,,[48],,,;,,,,,[49],()925235922.1-(-OH)(-NH)(-SH),-,(),,,,,,,,[50]2.2-,,,;(Calmodulin),,,:,,;(),,,,2.3,,,,[50],,;;,,2.4,bclBaxPCNA;(c2junc2losc2mycegr2lllllr277p53)[51];,,,DNA,DNA,3,,,,,[1].[J].,1992,11(6):272-276.[2].[M].:,2001:34-36.[3].[M].:,1991:22-52.[4],,.[M].:,1997.[5].[J].,2006,24(6):468.[6].[J].:,2006,22(1):66-67.[7],,.[J].,2005,32(6):2-4.[8],,,.[J].,1995,22(5):8-9.[9]GUNNARNORDBERG,.[J].AMBIO2,2002,31(6):478-481.[10],,,.[J].,2005,21(11):1333-1334.[11],,,.[J].,2006,24(1):23-26.[12],,.[J].,1995,8(2):71-73.[13].[J].:,1994,14(1):42-44.[14],,,.[J].,1997,4(7):31-36.[15],,,.[J].,2006,23(3):203-204.[16],,,.22[J].,2006,6(6):958-959.[17],,,.[J].,2006,32(4):54-56.[18],.[J].,2001,3(3):145-148.[19],,,.[J].,2000,23(1):4-5.[20],,,.[J].,2006,24(1):7-11.[21],,,.21[J].,2006,24(1):16-19.[22],,,.[J].,2005,22(3):193-196.[23],,,.HEK293[J].,2005,19(4):305-307.[24],.[J].,2004,21(2):150-152.[25],,,.[J].,1988,13(1):18-19.[26].[J].:,1999,26(5):286-288.[27],,,.[J].,1997,8(3):154.[28],,,.[J].,1998,16(1):5-8.[29],XIAN2LINSHI,,.RBCSOD[J].,2000,16(2):1-2.[30],,,.[J].,2006,24(1):3-6.[31],.DNA[J].,2005,22(6):523-524.[32],,,.[J].,2006,5(8):17-18.[33],.[J].:,2005,32(1):19-24.[34],,.[J].,1993,10(8):105-106.[35],,,.[J].,2006,32(4):209-211.[36],,,.[J].,2005,21(7):1356-1358.[37],,.[J].,2000,18(4):197-200.[38],,,.HL27702[J].:,2006,32(2):241-244.[39],,,.[J].,2000,20(1):34-36.[40].DNA[J].:,2000,27(6):359-361.[41],.DNA[J].,2005,17(1):41-44.[42],,,.DNA[J].,2005,31(6):404-408.03522007[43],,.[J].,2006,23(4):423-426.[44],,,.[J].,1998,16(l):43-46.[45],,,.Ca2+[J].,2006,39(4):350-356.[46],,,.[J].,2000,16(4):299-300.[47],,,.[J].,2005,19(1):41-42.[48],.[M].:,1989.[49],,.[J].,2005,21(3):327-328.[50].[J].,2005,40(11):26-28.[51].[J].,1998,16(1):2-4.(2527)SIF[23],SIF,,Morris,GENDNA[24],SIF,SIF,SIF,4SIF,SIF,SIF,,,,,,SIF,,,,SIF2080,SIF,,,,,SIF,,SIF?,?SIF,SIF,SIF,,[1],,.[J].,2006,15(4):160-162.[2],,,.[J].,2006(7):4-8,18.[3],,,.[J].,2005,25(9):550-553.[4],,.IGF2I[J].:,2005,34(6):696-698.[5],,,.[J].,2005,40(14):1057-1059.[6],.[J].:,2004,40(4):544-549.[7]HSIEHCY,SANTELLRC,HASLAMSZ,etal.Estrogeniceffectsofgenisteinonthegrowthofestrogenreceptor2positivehumanbreastcancer(MCF227)cellsinvitroandinvivo[J].CancerRes,1998,58(17):3833-3838.[8]SURENDRAPV,BARRYRG.Effectofsoy2derivedisoflavonoidsonthein2ducedgrouthofMCF27cellsbyestrogenicenvirvonmentalchemicals[J].NutrCancer,1998,30(3):232.[9],,,.PE04[J].,2003,20(3):139-141.[10]SETCHELLKD,ZIMMER2NECHEMIASL,CAIJ,etal.Exposureofinfantstophyto2oestrogensfromsoy2basedinfantformula[J].Lancet,1997,3530(9070):23-27.[11]YOUNGH,CLINTOND,ALLREDCD,etal.Physiologicalconcentrationsofdietarygenisteindose2dependentlystimulategrowthofestrogen2dependenthu2manbreastcancer(MCF227)tumorsimplantedinathymicnudemice[J].NutrandCancer,2001,131:2957-2962.[12],.[J].,2004,3(2):24-26.[13]YANGJ,NAKAGAWAH,TSUTAK,etal.Influenceofperinatalgenisteinex2posureonthedevelopmentofMNU2inducedmammarycarcinomainfemaleSprague2Dawleyrats[J].CancerLett,2000,149(122):171-179.[14],,.[J].:,2005,32(6):338-342.[15]NEWBOLDRR,BANKSEP,BULLOCKB,etal.Uterineadenocarcinomainmicetreatedneonatallywithgenistein[J].CancerRes,2001,61(11):4325-4328.[16],.[J].,2005,22(1):63-66.[17]BARRYD,THOMASJ,LOMAXLG,etal.EffectsofdietarygenisteinexposureduringdevelopmentonmaleandfemaleCD(Sprague2Dawley)rats[J].ReprodToxicol,2001,15(6):647-663.[18],,,.()[J].,2004,35(8):914-915.[19],,,.[J].,2003,17(3):164-166.[20],,.[J].,2006,26(2):48-50.[21],.[J].:,2000,27(6):336-340.[22]YELLAYIS,NAAZA,SZEWCZYKOWSKI,etal.Thephytoestrogengenisteininducesthymicandimmunech