_2型糖尿病与动脉粥样硬化相关性研究进展

2012123212Basic＆ClinicalMedicineDecember2012Vol．32No．122012－03－132012－05－11*[e-mail]1001-6325201212-1488-042*5410012、、Ⅱ1、、、。2Ⅱ1R541.4R587.4AStudyontherelationshipbetweentype2diabetesandarterialatherosclerosisHOUGuang-daoMOXin-ling*DepartmentofCardiovasculartheAffiliatedHospitalofGuilinMedicalCollegeGuilin541001ChinaAbstractThispaperreviewsthetype2diabetesandatherosclerosishardeningofthecorrelationanalysisandre-searchmainlyfromthegenepolymorphisminflammatoryfactorangiotensinⅡtype1receptorinsulinsuppres-sionglycosylatedhemoglobinandotheraspectsanalyzedthepotentialrelationsinpathologicalmechanisms．Theresultsmayprovideanewmethodforthepreventionandtreatmentofdiseases．Keywordstype2diabetesatherosclerosisgenepolymorphismangiotensinⅡtype1receptorinsulinsuppressionglycosylatedhemoglobin。、、、1。2。。2。3。2。4。。2。1。2ⅠGLO1A419C、GLO1C-7TC-106T2。2GLO1-7CC-7CTTT。GLO1C-7T25。RAGEApoE。Affymetrix9ApoERAGERAGEApoEβROCK16。-βTGF-β。TGF-β。TGF-βTGF-β。7。228。2β。reactiveoxygenspeciesROSβ2。ROS。ROS29。2reninangiotensinsystemRASⅡ1an-giotensinⅡtype1receptorAT1Rangioten-sinⅡtype1receptorblockerARBPPAR-γ。PPAR-γ。。ApoE-AT1R10。RASNADPHNADPHⅡRAS。NADPH。ARBs。ARBs11。AT2R。Ⅱ2angiotensinⅡtype2receptorAT2R。AT2R12。3solublereceptorforadvancedglycationendproductssRAGEsRAGE。13。advancedglycationendproductsAGEs。。β2。。β。214。29841Basic＆ClinicalMedicine2012.3212cardiovasculardiseaseCVD。CVD2。。3-2CVDβ。2。β。2CVD15。meta-bolicsyndromeMSB16。aorticelasticitydeclineAD。65ADDMDM。65AD。17。glycosylatedHbA1HbA1c。＞=5.5%～6.0%18。HbA1c。19。。。1．2J．201018643－646．2EscanedJColmenárezHFerrerMCetal．Diastolidys-functionindiabeticpatientsassessedwithDopplerechocar-diographyrelationshipwithcoronaryatheroscleroticburdenandmicrocirculatoryimpairmentJ．RevEspCardiol2009621395－1403．3．J．20071266－68．4．2/J．201018878－881．5WuJCLiXHWangJBetal．GlyoxalaseIandaldosereductasegenepolymorphismsandsusceptibilitytocarotidatherosclerosisintype2diabetesJ．GenetTestMolBio-markers201115273－279．6BuDXRaiVShenXetal．ActivationoftheROCK1branchofthetransforminggrowthfactor-betapathwaycon-tributestoRAGE-dependentaccelerationofatherosclerosisindiabeticApoE-nullmiceJ．CircRes20101061040－1051．7YangSNBurchMLTannockLRetal．Transforminggrowthfactor-βregulationofproteoglycansynthesisinvas-cularsmoothmusclecontributiontolipidbindingandac-celeratedatherosclerosisindiabetesJ．Diabetes20102233－242．8KajitaniNShikataKNakamuraAetal．Microinflamma-tionisacommonriskfactorforprogressionofnephropathyandatherosclerosisinJapanesepatientswithtype2diabetesJ．DiabetesResClinPract201088171－176．9KanetoHKatakamiNMatsuhisaMetal．Roleofreac-09412tiveoxygenspeciesintheprogressionoftype2diabetesandatherosclerosisJ．MediatorsInflamm20102721－11．10FukudaDEnomotoSHirataYetal．Theangiotensinreceptorblockertelmisartanreducesandstabilizesath-erosclerosisinApoEandAT1aRdoubledeficientmiceJ．BiomedPharmacother201064712－717．11HonjoTYamaoka-TojoMetal．PleiotropiceffectsofARBinvascularmetabolism-focusingonatherosclerosis-basedcardiovasculardiseaseJ．CurrVascPharmacol20119145－152．12KotkaACaoZKohPetal．AngiotensinⅡsubtype2receptorblockadeanddeficiencyattenuatethedevelop-mentofatherosclerosisinanapolipoproteinE-deficientmousemodelofdiabetesJ．Diabetologia201053584－592．13BastaGLeonardisDMallamaciFetal．Circulatingsol-ublereceptorofadvancedglycationendproductinverselycorrelateswithatherosclerosisinpatientswithchronickid-neydiseaseJ．KidneyInt201077225－231．14LorenzoCWagenknechtLED'AgostinoRBJretal．In-sulinresistancebeta-celldysfunctionandconversiontotype2diabetesinamultiethnicpopulationtheInsulinResistanceAtherosclerosisStudyJ．DiabetesCare20103367－72．15DeFronzoRADiabetologiaInsulinresistance．lipotoxici-tytype2diabetesandatherosclerosisthemissinglinksJ．TheClaudeBernardLecture2009．Diabetologia2010531270－1287．16MehtaNNKrishnamoorthyPMartinSSetal．Useful-nessofinsulinresistanceestimationandthemetabolicsyn-dromeinpredictingcoronaryatherosclerosisintype2dia-betesmellitusJ．Cardiol2011107406－411．17StaceyRBBertoniAGEngJetal．Modificationoftheeffectofglycemicstatusonaorticdistensibilitybyageinthemulti-ethnicstudyofatherosclerosisJ．Hyperten-sion20105526－32．18MatsushitaKBleckerSPazin-FilhoAetal．Theassoci-ationofhemoglobina1cwithincidentheartfailureamongpeoplewithoutdiabetestheatherosclerosisriskincom-munitiesstudyJ．Diabetes2010592020－2026．19RiveraJJChoiEKYoonYEetal．AssociationbetweenincreasinglevelsofhemoglobinA1candcoronaryathero-sclerosisinasymptomaticindividualswithoutdiabetesmel-litusJ．CoronArteryDis201021157－163．UlipristalWebMD2012-02-19ulipristal。ulipristal、、。JeffreyT．Jensen。Ulipristal。2010。ulipristal30mg5mg10mg。15mg、10mgulipristal242、18～50、。2008102010838。2“”ulipristal5mg10mg1leuprolide。CliniquesUniversitairesSaint-LucJacquesDonnez5mgulipristal9691%10mg9892%4819%P≤0.001。10mgulipristal82%5mg73%6%。1941