原子力学显微镜对液体纳米药物的直接观察

[]100521139(2005)05203522021,1,1,2(1.,100853;2.,100853)[]:::,,,:[];,[]O46.1[]ANanomedicineabserveddirectlybyatomicforcemicroscopeSONGShu2zhen1,TIANYa2ping1,WANGDeng2qing1,JIXiao2long2(1.ClinicalBiochemicalDepartment,PLAGeneralHospital,Beijing100853,China;2.DepartmentofClinicalPathology,GeneralHospitalofArmedPoliceForce,Beijing100039,China)[Abstract]Objective:Toestablishthemethodfortheobservationofhumanurine.Methods:Atomicforcemicroscopewasusedtoobservenanomedicine.Results:Medicineuntreatedbynanotechnologywerenotuniform,andthegranulesweredifferentinsizeandshape,thebigoneslookedascrystalsinlightmicroscope,whilethesmalloneswereonlyabout300nanometersinsize.Nanomedicinewerefoundtobeuniforminsizeandshape,thegranuleswerefrom100to300nanometers.Conclusion:theresultsprovidetheprimarystudiesofnanomedicinemaybeusefultothefurtherapplicationofnanomedicineinbiomedicine.[Keywords]nanomedicine;microscopy,atomicforce(AFM),,,[1],,;,[2](AFM),11.1(YOSHIDANanomizersystemNMII,NCJJ0.008/150),CSPM2000wtAFM,,55m55m,[]2005202216[]2005203210[](03YC09)[](19702),,,2001,:[phone],Email:[e-mail]200m,90m,(contact2mode),13Hz1.20.125%,(,27g/L,700SOD),0.125%,1.3:150MPa,3:,2h,,;,1%10g/L1.4,50l,,AFM10AFM253AcadJPLAPostgradMedSch2005Oct,26(5)CSPM2000online22.10.125%,,(1a),(1b)2.2,,,,m(1c),(1d)1Fig1Imageofmedicinebyatomicforcemicroscopea:0.125%Turtlegeluntreatedbynanotechnology.b:0.125%Turtlegeltreatedbynanotechnology.c:Cornextractionuntreatedbynanotechnolo2gy.d:Cornextractiontreatedbynanotechnology3300nm,,,,[3],,,,,,,[4](,[5],),,AFM,,[6],AFM,[][1]EguchiT,FujikawaY,AkiyamaK.ImagingofallDanglingBondsandtheirpotentialontheGe/Si(105)surfacebynoncontactatom2icforcemicroscopy[J].PhysRevLett,2004,93(26):266102.[2]...2[J].,2003,24(2):1232125.[3]RobertsCJ.Whatcanwelearnfromatomicforcemicroscopyadhe2sionmeasurementswithsingledrugparticles[J]?EurJPharmSci,2005,24(223):1532157.[4],.[J].,2000,21(3):1782180.[5]EmerichDF,ThanosCG.Nanotechnologyandmedicine[J].Ex2pertOpinBiolTher,2003,3(4):6552663.[6]BerdyyevaT,WoodworthCD,SokolovI.Visualizationofcytoskel2etalelementsbytheatomicforcemicroscope[J].Ultramicrosco2py,2005,102(3):1892198.[]100521139(2005)0520353201Ci8200,,(,100853)[][]O46.1[]B11.1[]2005202216[]2005203210[](19792),,,2004:(010)669362141.1.1(ABBOTT)architectCi8200;(Hitachi)7600;(Roche)E1701.1.2;;1.1.3(),6050(379)353AcadJPLAPostgradMedSch2005Oct,26(5)