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,:pH,52HMF,,,[8](20),pH7.047.435d,57d4[9];,(Cl-),Pi,HCO3-,,:Cl-,Cl-HCO3-CO2,,,4,5,,,:,1.,.:,1994,2312,.44.,1997,17(4):2763VinayP,etal.Acetatemetabolismduringhemodialysis:metabolicconsiderations.AmJNephrol1987,7:3374,..,1985,(1):105MehatBR,DianeF,MasoodA,etal.Effectsofacetateandbicarbon2atehemodialysisoncardiacfunctioninchronicdialysispatients.Kid2neyInt,1983,24:7826RosaAA,etal.ArchIntMed.1980,140(6):8047,,...1995,16(5):4818,.5%GNS52HMF.,1996,17(6):4999,..,1994,10(1):46(1998110)(518107),,,,[1][2],[3],11.11.1.1Beckett,,Moffat16P22N2,,,1.1.2:,,,Ebert[4](6000),,Hoogstraate[5]4,10,20kDa,FITC,,FITC4,10kDa,20kDa60319991951.2,,,,15%30%[629]0.5%W/V0.1%W/V,4h,,,,,,[10]1.3MG1[11],,[12];,;0.1%,,[13]22.1,,2.2,,,,2.32.3.1(1),EDTA,;(2),,;(3),;(4),;(5),2.3.2[14],,,2,,,2.3.3[15]:(1)/,(2)3,58mm,,1015cm2,13cm2,[10],,CMC2Na,Car2bopol934,PAA,HPMC,PVA,,[16],Carbopol934,,,,28h,,,[17]4,,,,1MerkleHP.Buccaldeliveryforpeptidedrugs.JContrRel,1992,21:1552HarrisD.Drugdeliveryviathemucousoftheoralcavity.JPharmSci,1992,81:13SenelS.Enhancementofinvitropermeabilityofporcinebuccalmu2cosabybilesalts:kineticandhistologicalstudies.JcontrRel,1994,32:374EbertCD.Mucosaldeliveryofmacromolecules.JContrRel,1994:28:375HoogstraateAJ,DiffusionratesandtransportpathwaysofFITC2La2beledmodelcompoundsthroughbuccalepithelium.JContrRel,1994,28:2746DowtyME.Transportoftheyrotropinreleasinghormoneinrabbitbuccalmucosainvitro.PharmRes,1992,9:11137KurosakiY.Enhancedpermeabilityofkeratinisedoralmucosatosal2icyacidwith12dodecylazacycloheptan222one(Azone).Invitrostudies7031999195inhamstercheekpouch.IntjPharm,1989,49:478VriesD.Localizationofthepermeabilitybarrierinsideporcinebuccalmucosacombinedinvitroofdrugpermeability,electricalresistanceandtissuemorphology.IntJPharm,76(1991)259GhandiR.Mechanismsofpenetrationenhancementfortransbuccaldeliveryofsalicylicacid.IntJPharm,1992,85:12910RathboneMJ.Theoralcavityasasiteforsystemicdrugdelivery.AdvDDelRev,1994,13,111LevineMJ.Functionofhumansalivaandsalivarymucins.pp2412SiegelIA.Permeabiltyoftheoralmucosa.pp,9513RomanowskiAR.Contributionofsaliverymucinestotheoralmu2cosalpermeabilitybarrier.JDentRes,1987(66)Abstract105414SquierCA.PermeabilityandthepathophysiologyoforalmucosaAdv.DDelRev,1993(12)13:2415Coutel2EgrosA.CombinedeffectsofpHcosolventandpenetrationenhancersontheinvitrobuccalabsorptionofpropranololthroughexcisedcheekpouch.IntJPharm,1992,(84):11716TaylanB.Designandevaluationofsustained2releaseandbuccalad2hesivepropranololhydrochloridetabiets.JContrRel,1996(38):1117GuoJH.Investigatingthebioadhesivepropertiesofpolymerpatch2esforbuccaldrugdelivery.JContrRel,1994(28):273(1998630)2(402100039),,2,,:1.,,8512h,199626:T36,P84min-1,R16min-1,BP24/12kPa,,,,,,80min-1,,,,(+):4.89mmolL-1,121molL-1,4.18mmolL-1,(-)CT(34cm2)20%250mlq6h,3,,,400ml(24h-1),6.82mmolL-1,,,7.16mmolL-1,19.64mmolL-1,42.,,511,1996214,2,:9.28gL-1,1.2107L-1,3.39mmolL-1,5.6mmolL-1,73.37molL-1,,20%250mlq6h3d,,400ml(24h)-1,7.91mmolL-1,10.78mmolL-1,684molL-1,T,,2200gd-1,3,(1998527)2(271600),,,19942(ALT),1.,45,1,3d,1997526:aVFV1V2V3ST0.10.2mV(,95051322)400mg5%250ml,,2d:ALT22uL-18d:ALT103uL-1,HBsAg(-),,,200mg5%250ml,7d:ALT27uL-1,ALT2.,565,5d1998411:(,96061822)400mg5%250ml,,:ALT27uL-17d:ALT119uL-1,,200mg5%250ml,7d:ALT41uL-12d,ALT,,ALT(199863)8031999195
本文标题:口腔粘膜给药系统
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