对1953例药物性血尿报告的分析-对1953例药物性

,733FK506Tab3ThereasonsoftheabnormalwholebloodconcentrationofFK506/%/71(62/9)22.8(19.9/2.9)8226.33511.2237.4227.0258.05417.33121003.3FK506,44FK506Tab4Thedrugsofraisingbloodconcetrationwhencoadminis2trationFK506FK506/%FK5064959.8,FK506133239.0FK506311.2823.4MEIAELISA12FK506,,:MEIA=0.696ELISA+2.239(r=0.98)4FK506,256,46.04%(2),,0.15mgkg-1d-1,0.02mgkg-1d-1,,,FK506FK506,FK506,FK506[2]FK50610.73h,36h90%[3]FK50611.2%,FK506FK506MEIAELISA,,,,20.03mgkgd-10.18mgkgd-1,FK506,FK506,,,,:[1],,.[J].,2001,22(5):222.[2],,,.[J].,2002,22(6):346.[3],,.[J].222,2001,22(2):93.[]2004209202[],,,,:066328638107,13925623088,E2mail:[e-mail]1953(,522000)[]:,:10:,+++:,,[];;[]R978.1[]A[]100125213(2005)0820747202,,,10,1CNKICNKI-CHKD1994200411,69,108,195322.119531289(66%),664(34%),10d,670171904,97.49%(126466.39%,64033.61%);18492.51%(25,24)2.2934(47.82%),853(43.68%),85(4.35%),+28(1.43%),+53(2.71%)7472005258ChinHospPharmJ,2005Aug,Vol25,No.8©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.2.3,,11Tab1Classificationofdrugsandcaseofmedicationbringinghematuriain1953cases/1188134269726013431109042722502210541+32+5+20+3+3++1+3+1+1+3+1+1+1+1+1+6+5+7+1+26511872814771521162APC81838461+68+APC1+1++1+50+3+1++2++1++APC1++1++APC1+3+24612(4)13110212121461953:2.42210Tab2Theprimary10preparationsofmedicationbringinghe2maturia%169735.69247722.4231055.384904.615723.696603.077502.568+502.569+321.6410+201.02165384.64:+,22.5,12(4)1311021233.14:(1);(2);(3);(4),,,100nm,300nm[1],,66%,34%,[2],3.2934,47.82%,,,,,T1/211.5h,90%[3],0.5g,2000mgL-1,16mgL-1[4],,57d,710d,[5.6](NSAIDs),,,(,,,15mg,15mg,2.5mg),NSAIDsE,E,[7]19801998489,(NSAIDs),,,19801998(NSAIDs),,:[1].2[J].,1995,26(2):82.[2],.[J].,2002,13(2):104105.[3],.16[J].,1996,9(8):375.[4].12[J].,1999,16(6):34.[5]SundinDP,MeyerC,DablR,etal.Cellularmechanismofamino2glycosidetoleranceinlong2termgentamicintreatment[J].AmJphysiol,1997,272(4pt1):C1309C1318.[6]MurakaniH,YayamaK,ChaoL,etal.Humankallikreingenede2liveryprotectsagainstgentamycin-inducednephrotoxicityinrats[J].KidneyInt,1998,53:13051313.[7],.489[J].,2000,2:8890.[]20042122138472005258ChinHospPharmJ,2005Aug,Vol25,No.8©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.