小儿抗癫痫药物的不良反应

:(200032)1:-(GABA),;,;,,GABA;GABA,,;,VitD3,;:,K;;1--;2211,20001,[1];,(1%);,50%4%;,,35%(2109/L4109/L),,4%[2,3],(20%),,1/1000,[4]212,,;,,,;,VitD3,,,40,(AKP),,:T3T4FT3[5],,1%,;,;;A,A,;-,-,-[6],,[7],-,(AIP),1%419%[1],AIP[8],,07520009159,AIP213,,4%,5%,10%,10%,6%[1,3];(1%);,,,25%,,,Stevens-Johnson[9],,,,[10],,25%,23,912,3629%,018%214,Okuno90,16%;,4%6%1%[11];,25%,;,;,,,,2%,(9%)(14%),,10%25%25%,118%,,,7%,[12],,,14%,,415%,55%1%,5%4%215,,115%[1],216a.:,,,,20%,5%;14%;1%;14%,,3%5%[13];(15%),14%;1%,9%1215%,6%2%;1%;,b.:;2%;11%9%6%;5%111%12%2%[13],,(REM),;,c.:39%15%,;[14];5%d.:Calandre17520009159EP64-:,,,73,,[15]108;107,,;33,;50,33:,:11PBPRIPHTVPACBZOXCBZETHVGBLTGBROGBPFBMTGBTPM+++++++++++++++++++++++++++++++++++++++3++3++++3+++3++++++++++++++++++++++++++++++++++++++++++++++:=01001%0199%;+=1100%4199%;++=5100%9199%;+++10%;++3=PB,PRI,PHT,VPA,CBZ,OXCBZ,ETH,BRO,FBM,LTG,TGB,TPM,VGB217,,IgA40%;177,IgGIgM,IgGIgM;,()(2%);218,,219,,,,,,,KanekoS27520009159311%910%,:[17],[18]()22()PBPRIPHTVPACBZOXCBZETHBROFBMLTGTGBTPMVGB++++++++++++++++++++D++++++++++++++++++++++++++++++++++++()+++D()+:=01001%0199%;+=1100%4199%;++=5100%9199%;+++10%;DPB,PRI,PHT,VPA,CBZ,OXCBZ,ETH,BRO,FBM,LTG,TGB,TPM,VGB320,,,;Lennox-Gastaut,();SchlumbergerE20,850%,6,[1,19]4,VitK,,VitK1;,,,,,,[20],,,,[1],:10%,8%,8%,4%,3%,10%,3%4%,10%,,,;,,1WallaceSJ.Acomparativereviewoftheadverseeffectsofanticonvulsantsinchildrenwithepilepsy.DrugSafety,1996;15(6):3782MattsonRH.Efficacyandadverseeffectsofestablishedandnewantiepilepticdrugs.37520009159Epilepsia,1995;36(suppl2):S133ChadwickDW,MarsonT,KadirZ.Clinicaladministrationofnewantiepilepticdrugs:anoverviewofsafetyandefficacy.Epilepsia,1996;37(suppl6):S174HerranzJL,ArmijoJA,ArtegoR.Clinicalside-effectsofphenobarbitone,primidone,phenytoin,carbamazepineandvalproateduringmonotherapyinchildren.Epilepsia,1988;29(4):5305,..,1999;17(1):276MeleghB,PapM,MorovaE,etal.Carnitinedependentchangesofmetabolicfuelconsumptionduringlong-termtreatmentofvalproicacid.JPediatr,1994;125(7):3177KuharaT,InoueY,MatsumotoM,etal.Markedlyincreased-oxidationofvalproateinfulminanthepaticfailure.Epilepsia,1990;31(1):2148TatumWO,ZacharianSB.Gabapetintreatmentofseizuresinacuteintermittentporphyria.Neurology,1995;45(6):12169SchliengerRG,ShearNH.Antiepilepticdrughypersensitivitysyndrome.Epilepsia,1998;39(suppl7):S310,,..,1998;36(8):49411LeeWM.Drug-inducedhepatotoxcity.NEnglJMed,1995;333():111812..,1998;36(8):49813pellockJM,AppletonR.Useofnewantiepilepticdrugsinthetreatmentofchildhoodepilepsy.Epilepsia,1999;40(suppl6):S2914McleanMJ.Gabapetin.Epilepsia,1995;36(suppl2):S7315LeppikIE.Roleofnewandestablishedantiepilepticdrugs.Epilepsia,1998;39(suppl5):216,..,1998;25(1):2917ChenY,KangW,Chin-minSoW.Comparisonofantiepilepticdrugsoncognitivefunctioninnewlydiagnosedepilepticchildren:apsychometricandneurophysiologicalstudy.Epilepsia,1996;37(1):8118KanekoS,BattinoD,AndermannE,etal.Congenitalmalformationsduetoantiepilepticdrugs.EpilepsyRes,1999;33(2-3):14519GuerriniR,BelmonteA,GentonP.Antiepilepticdrug-inducedworseningofseizuresinchildren.Epilepsia,1998;39(suppl3):S220McdermottCA,KowalczykAL,SchnitzlerER,etal.Clinicalandlaboratoryobservations:phamacokineticsoflorazepamincriticalillneonateswithseizures.JPediat,1992;120(3):479(2000-03-292000-06-09)(:):(530700)211,11,9kg3,,,9mg,10,,,:38,,,,,,,,,,,,(-),,,621,6,6kg2,3615,,,,,,6mg,7,,,,,,,K+Na+Cl-Ca2+Mg2+,,4:,,,2,:2611,,,,,,,,(2000-04-252000-07-10)(:)47520009159