小油桐生物活性成分与药用价值研究进展

,414,,,,,,,,,415,,,,,,,416,,,,,,12022[1],,,11,1998,17(3):212241[2],,,11:,2002,4(1):502511[3],,,11,2005,14(7):532541[4],,,11,2003,14(9):53125321[5]11,1994,11(3):382401[6],11,2002,29(6):33623401[7],,,11,2005,22(3):17621801[8],,,11,2005,40(16):1238212411[9],,,11,2003,38(6):43824421[10]11,2005,12(4):522531[11],11,2000,25(12):75527561(2007-05-28)1,2,13(11,,510275;21,510282),;;:R28412/R28515:A:100124454(2007)1021332205:,,,;E2mail:wangzhaoyu77@yahoo1com1cn3:,,,E2mail:xuzengfu@mail1sysu1edu1cn,Tel:[phone](JatrophacurcasL1),,,,,2331JournalofChineseMedicinalMaterials30102007101,2,3,4,300,40%60%(21%,79%),(19%27%)5,,,,,,6,,1,1112,(NationalCancerInstitute,NCI)79:A(Jatrop2holoneA)B(JatropholoneB)(Jatrophol)CitalitrioneCaniojaneCurcusoneACur2cusoneBCurcusoneCCurcusoneD2,8,9AB,C20H24O2,296,,A231233,B236238,,A2(Rf,rateofflow)B2,C20H24O3,312,1901922Citlalitri2one,C20H26O4,330,19419610Caniojane,C20H24O3,312,167168,9CurcusoneACurcusoneBCurcusoneCCurcusoneD,(curcusone),C20H28O4,33281222162(122deoxy2162hydroxyphorbol)11,711211,7,(apigenin)(5,7,4’2,)(vitexin)(isovitexin)125,4’226,72(5,4’2dihydroxyflavon26,72glucoside)5223,7,4’2(52hydroxyfla2von23,7,4’2rhamnetin)13(flavonoid)(flavonoid)14;4,(5,6,7,8,3’,4’2,nobiletin)5,223,62(52stigcastane23,62dione)1552222(52hydroxyprrolidin222one)22,42(pyrimidine22,4,2dione)16172191136,(fraxe2tin)7(jatrophin)5226,72(tomentin,52hydroxy26,72dimethoxycouma2rin)2072262(scopoletin,72hy2droxy252methoxycoumarin)2,215,72(5,72dimethoxycoumarin)6,72(6,72dimethoxycoumarin)22,,,,,23,24114,2(2sitosterol)25(daucosterol)2(stigmasterol)(steroidsapogenins)26,27D,,,,28,,,29,,,,3331JournalofChineseMedicinalMaterials301020071029115306(jatrophine)7,31233;25;61167,1812%,:(1)curcain,,,;(2)curcin,,,ricincrotin,RNAN2,,(RIPs)342211Ravindranath(2004)palmarumycinCP1JC1JC2,(Staphylo2coccus)35(2004)(PyriculariaoryzaeCav1)(PestalotiafunerealDesm1)(RhizoctoniasolaniKuha1)[Sclerotiniasclerotiorum(Lib)deBary],curcin,curcin100g/ml,36(2004)3,52237212Matsuse(1999)DiaionHP220,,5,72(5,72dimethoxy2coumarin)6,72(6,72dimethoxy2coumarin),HIV(humanimmunodeficiencyvirus),(CC50/IC50)4117,,HIV,HIV,HIV2protease(HIV2PR)22,(watermelonmo2saicvirus,WMV)38213,,30,39,Fagbenro(1998)(Papiliode2moleusL1)27,(2004)(Lipa2phiserysimiKalt1)40214Taylor(1983),015mg/LP2388(3PS)41%,KB(ED50)0117g/ml,41(1988)830,7915%,42(2003)curcin,curcin,(IC50)0119nmol/L,SCG27901SP2/0IC500123mg/L0166mg/L3116mg/L,(Helacells),curcinRNAN243215115g/kg,4445,Marraquin(1997)30147,,,,,10,1622046,(Na+),,,4748,,4331JournalofChineseMedicinalMaterials3010200710;,;30,,30,,,,,303,,(2002)8649,,,50420,51,2006930()([2006]702),200612132006242,,,,,,,,,,HIV,[1]1(,)1:,1996:14721481[2],,,11,1996,38(2):16121661[3]11,2006,24(4):742761[4],,,11,2006,45(1):572581[5]OpenshawK1AreviewofJatrophacurcas:Anoilplantofunfulfilledpromise1BiomassandBioenergy,2000,19(1):12151[6],,,11,2002,9(10):332361[7],,,11,2004,12(3):28522901[8]MuangmanS1Anti2tumoractivityofJTT22,acompoundextractedfromJatrophacuraca1MahidolUniversity,2004:21[9],,11,2006,29(5):50025051[10]VillarrealA,DominguezX,WilliamsH,etal1Citlalitri2one,anewditerpenefromJatrophadioicavar1sessiliflo2ra1Journalofnatrualproducts,1988,51(4):74927531[11]AdolfW,OpferkuchH,HecherE1Irritantphorbolderiv2ativesfromfourJatrophaspecies1Phytochemistry,1988,23(1):12921321[12]SubramanianS,NagarajanS,SulochanaN1FlavonoidsofsomeEuphorbiaeousplants1Phytochemistry,1971,10:2548225491[13]KhafagyS,MohamedY,Abdel2salamN,etal1Phyto2chemistrystudyofJatrophacurcas1PlantaMedical,1977,31(3):27422771[14]KhafagyS1ComponentsfromtheleafofJ1curcas1PlantaMedical,1977,31(3):27422761[15],,11,1988,30(3):30823111[16]StaubmannR,Schubert2zsilaveczM,HiermannA,etal1Acompexof52hydrocypyrrolidin222oneandpyrimidine22,42dioneisolatedfromJatrophacurcas1Phytochemistry,1999,50(2):33723381[17],,11,2005,32(4):49825041[18],,,11,2005,40(11):1001210071[19],11,2005,22(5):332341[20]KongL,JinD,MinZ1ThediterpenoidsfromJatrophacurcas1WorldPhytomed,1993,8(6):243224515331JournalofChineseMedicinalMaterials3010200710[21]OjewoleJ1AntibronchoconstrictorandantiarrhythmiceffectsofchemicalcompoundsfromNigerianmedicinal1Fitoerapia,1983,54(4):15321611[22]MatsuseI,LimY,HattoriM,etal1Asearchofanti2viv2alpropertiesinPanamaninamedicinalplants:TheeffectsonHIVanditsessentialenzymes1JournalofEthnophar2macology,1999,64(1):152221[23],,,140A432BCAP1,2006,8(12):92101[24],,11,2006,26(3):28522871[25]NaengchomnongW,ThebtaramonthY,WiriyachitraP,etal1Isolationandstructuredeterminationoftwonovella2thyranfromJatrophacurcas1RetrahedronLetters,1986,27(4):5675256781[26]TeixeiraJ1ContentandchemicalcompositionoftheJatro2phaspp1seedoil1Bragantia,1987,46(1):15121571[27],,,11(),2006,23(2):10521101[28]11,2007,34(2):10121051[29],11,2007,34(2):9821011[30],11,2006,(11):642651[31],,11,2006,46(6):32234,421[32],11,2006,13(6):91629171[33],1501,2007,7(1):511[34],,,11,2002,12(11):362401[35]RavindranathN,ReddyM,RameshC1NewlathyrineandpodocarpanediterpenoidsfromJatrophacurcas1ChemicalandPharmaceuticalBulletin,2004,52(5):60826111[36],,,1(curcin)1,2004,26(3):712