我院154例神经系统药品不良反应回顾性分析

852ChinaPharmacy2005Vol.16No.11200516111541*,2(11,100053;212001,100053)R96C1001-0408(2005)11-0852-03::19992003154(ADR):ADRADR14.27%;18,:,;;RetrospectiveAnalysisof154CasesADRofNervousSystemMedicineQIXiaolian(Dept1ofPharmacy,XuanwuHospitalofCapitalUniversityoftheMedicalSciences,Beijing100053,China)LIANGWeini(HigherVocationalPharmaceuticalClass,2001Grade,CapitalUniversityoftheMedicalSciences,Beijing100053,China)ABSTRACTOBJECTIVE:Tostudythedamageofdrugstothenervoussystem1METHODS:154casesofadversereactionsofnervoussystemdrugscollectedfrom1999to2003inourhospitalwereanalyzedstatistically1RESUTLS:ADRofnervoussystemaccountedfor14127%ofalltheADRcasesinourhospital;therewere18kindsofdrugsinvolvedinADR,whichin2cludedtheanti-infectiondrugs,Chinesedrugspreparation,cardiovascularsystemdrugs,nervoussystemdrugs,antipyreticanalgesicetc1CONCLUSION:Itisofgreatclinicalsignificancetokeepalert,toidentifyandavoidtheadverseeffectsofdrugsonnervoussystem1KEYWORDSNervoussystem;Adversedrugreaction;Analysis*::010-63013355-2352E-mail:qxlxw@1631com,(ADR),ADRADR2418%2618%[1],,ADR,,19992003ADR,,119992003ADR154()ADRADRADRADRADR2211ADR1075,ADR154,14127%5896;54160(3,89);189(5184%),185564(41156%),5581(52160%);ADR86(55184%),55(35172%),13(8144%);ADR107(69148%),45(29122%),2(1130%);ADR,41(26162%),100(64194),12(7179%),1(0165%)212ADR154,18,1213ADR154,83(53190%),66(42186%),2(1130%),1(0165%),149,96175%,2214ADRADR,,[2],3215ADR,ADR13,ADR4ADR,ADR()©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.20051611ChinaPharmacy2005Vol.16No.118531ADRTab1DrugsthatleadtoADRofnervoussystemandthefrequencyofADR()(n)(%)196542121{(25)(1)(3)}{}(9)(8){(1)(3)}{(2)(1)}(2)/{}(2){}(1)/{}(1){}(1)(1)(1){}(1)(1)(1)192818119(2)(1)(1)(1)(1)(2)(1)(1)(1)(1)(1)(1)(1){}(5){(1)(1)}(1)(1)(2)(1)(1)111711104{(1)(1)}(3){(1)(3)}{}(2){}(1){}(1)(1){}(1){}(2)111510140(2)(2){(1)(1)}(1)(2){}(1)(1)(1)(1)(1){}(1)685119*(2)*{}(1){}(2)*(1){}(1)*{}(1)221130{}(1)(1)242160{}(2)(2)121130(2)221130{}(1){}(1)221120(1){}(1)110165{}(1)110165{}(1)221130{}(1){}(1)110165(1)110165(1)110165(1)110165(1)110165{}(1)**standsfortheover-the-counterdrugs2ADRTab2Drugsbyi1v1andperosthatleadtoADRofner2voussystem(n)(%)(n)(%)5465106111616714161871218118561021218118561021015115441820111211115281211223103231032310323103111521115211152111523ADRTab3ClinicalmanifestationofADRandthefrequencyoftherelateddrugsuse(n)(%)7347140(14)(4)(6)(2)(2)(2)(2)(1)(2)(1)(1)(2)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)2616188(4)(1)(1)(2)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(1)(2)(1)1811169(2)(3)(4)(2)(1)(1)(2)(1)(1)(1)()106150(2)(1)(1)(1)(1)(1)(1)(1)52160(1)(1)(1)(1)(1)10165(1)53125(1)(1)(2)(1)()31195(1)(1)(1)()127179(1)(1)(1)(3)(1)(1)(1)(1)(1)(1)21130(1)(1)42160(1)(1)(1)(1),()10165(1)21130(1)(1)21130(1)(1)21130(1)(1)4ADRTab4DistributionofdrugsinducedtoseriousADRofthenervoussystem(n)(%)5717021313315188131571251001100100110010011001003ADR,,52160%,,,,,;,,;,,[2]ADR5©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.854ChinaPharmacy2005Vol.16No.1120051611*::0755-8398222-8321E-mail:wufangtai@1631com*,,,,(,518033)R92712A1001-0408(2005)11-0854-02::,233nm:110g/ml(r=019999);9913%(RSD=0124%,n=9):,;;;,86136%,,42121%,25,,,,,,t1/2,,,,,3/4ADR18119%,,,,ADRADR83,ADR662,ADRADR,83108%(54/65),,,ADRADR,50%,ADR5(17186%,5/28),,ADRADR66167%(12/18),,,ADR,,,ADRADR,62150%(5/8),,,4,,;,,,,ADR,,,ADR,,[1],1[M]1:,1996:1351[2],1[M]131:,2003:6776,1941951[3]1()[S]120001:,2000:7027041[4]1-5-[J]1-,2002,29(5):4511(:2005-01-12:2005-03-09)DeterminationofMetforminHydrochlorideinCompoundMetforminHydrochlorideTabletsbyUV-Spec2trophotometryWUFang,CHENLianjian,LICheng,LITing,HUANGFuxing(FutianPeople’sHospitalofShenzhen,Shenzhen518033,China)ABSTRACTOBJECTIVE:ToestablishUV-spectrophotometrymethodinthedeterminationofmetforminhydrochlorideincompoundmetforminhydrochloridetablets1METHODS:Thedeterminationwascarriedoutwithwaterasthesolventunderthedetectionwavelengthof233nm1RESULTS:Therewasagoodlinearrelationshipbetweenmetforminhydrochlorideanditsabsorbability(r=019999)withintheconcentrationrangeof110g/ml1Theaveragerecoverywas9913%withRSDat0124%(n=9)1CONCLUSION:Themethodisaccurate,fast,convenient,andwhichcanbeusedtodeterminethecontentsofmetforminhydrochlorideincompoundmetforminhydrochloridetabletsdirectlywithoutisolation1KEYWORDSCompoundmetforminhydrochloridetablets;UV-spectrophotometry;Metforminhydrochloride;Contentde2termination©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.