Irgacure-2959-EN

FileNo:NA/991January2002NATIONALINDUSTRIALCHEMICALSNOTIFICATIONANDASSESSMENTSCHEMEFULLPUBLICREPORT4-(2-hydroxyethoxy)phenyl-(2-hydroxy-2-propyl)ketone(Irgacure2959)ThisAssessmenthasbeencompiledinaccordancewiththeprovisionsoftheIndustrialChemicals(NotificationandAssessment)Act1989(theAct)andRegulations.ThislegislationisanActoftheCommonwealthofAustralia.TheNationalIndustrialChemicalsNotificationandAssessmentScheme(NICNAS)isadministeredbytheNationalOccupationalHealthandSafetyCommissionwhichalsoconductstheoccupationalhealth&safetyassessment.TheassessmentofenvironmentalhazardisconductedbytheDepartmentoftheEnvironmentandtheassessmentofpublichealthisconductedbytheDepartmentofHealthandAgedCare.Forthepurposesofsubsection78(1)oftheAct,copiesofthisfullpublicreportmaybeinspectedbythepublicattheLibrary,NationalOccupationalHealthandSafetyCommission,Plazalevel,AlanWoodsBuilding,25ConstitutionAvenue,CanberraACT2600between9AMand5PMMondaytoFriday.Copiesofthisfullpublicreportmayalsoberequested,freeofcharge,bycontactingtheAdministrationCoordinatoronthefaxnumberbelow.ForenquiriespleasecontacttheAdministrationSectionat:StreetAddress:334-336IllawarraRdMARRICKVILLENSW2204,AUSTRALIAPostalAddress:GPOBox58,SYDNEYNSW2001,AUSTRALIATelephone:(61)[phone]FAX[phone]DirectorChemicalsNotificationandAssessmentTABLEOFCONTENTSFULLPUBLICREPORT...........................................................................................................31.APPLICANT..................................................................................................................32.IDENTITYOFTHECHEMICAL.................................................................................33.PHYSICALANDCHEMICALPROPERTIES.............................................................43.1CommentsonPhysico-ChemicalProperties..........................................................54.PURITYOFTHECHEMICAL.....................................................................................55.USE,VOLUMEANDFORMULATION......................................................................66.OCCUPATIONALEXPOSURE...................................................................................67.PUBLICEXPOSURE....................................................................................................88.ENVIRONMENTALEXPOSURE................................................................................88.1Release...................................................................................................................88.2Fate.........................................................................................................................99.EVALUATIONOFTOXICOLOGICALDATA...........................................................99.1SummaryofToxicologicalInvestigations..............................................................99.2AcuteToxicity......................................................................................................109.2.1AcuteOralToxicity(Merck1987)...............................................................109.2.2AcuteDermalToxicity(Merck1987a)........................................................119.2.3AcuteInhalationToxicity.............................................................................129.2.4SkinIrritation(Merck1987b)......................................................................129.2.5EyeIrritation(Merck1987b)........................................................................129.2.6SkinSensitisation(Merck1988)..................................................................139.3RepeatDoseToxicity(Merck1988a)..................................................................149.4Genotoxicity.........................................................................................................159.4.1.1Genotoxicity-Bacteria(Merck1987c)..........................................................159.4.1.2Genotoxicity-Bacteria(Merck1991)...........................................................169.4.2Genotoxicity-InVitro(Merck1988b)..........................................................179.4.3Genotoxicity-InVivo...................................................................................189.5OverallAssessmentofToxicologicalData..........................................................1810.ASSESSMENTOFENVIRONMENTALEFFECTS.............................................18WaterFlea....................................................................................................................1911.ASSESSMENTOFENVIRONMENTALHAZARD.............................................2012.ASSESSMENTOFPUBLICANDOCCUPATIONALHEALTHANDSAFETYEFFECTS.............................................................................................................................2013.RECOMMENDATIONS.........................................................................................2214.MATERIALSAFETYDATASHEET....................................................................2315.REFERENCES...