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*20023721TQ464A1672-3651200604-0246-042006-07-05*Tel021-64252255E-mailQsyuan@ecust.edu.cn2111457020090212002202122-970901620199618519971230200069!#ChinJNatMedJuly2006Vol.4No.4200674420039912%IFN-αIL-2GM-CSFEPO15t-PAIL-3UKrh-SODⅠ~ⅢB402000130070045%28%31%AmgenGe-neticsinstituteGenzymeChironBiogen3310-143.1160%~70%65%~70%EPOCHOP532FDATNFTNFRemicade-FeEnbre1Humira31986OK-T32002anti-CD203.2122006744ChinJNatMedJuly2006Vol.4No.4!#4IFN-α1b52315-1851005.1100I~ⅢFDArhGHrhFSHrhHCGrh-SODIGF-1TGF-αFGF-βNGFG-CSFintegrinfamilyimmunoglobulinsuperfamilyIgSFselectinfamily5.2IL-2125CysSerIL-2IL-25.318Isis2922FDA5.4200062697%85%50%5.51235.61!#ChinJNatMedJuly2006Vol.4No.42006744231WangFSLingPX.M.1997.2WuWT.21.M.2002901-907.3WuWTWangYTWuWJ.21J.PharmBiotech-nol20018261-65.4ZhuangLG.J.20023711-14.5TulpMBohlinL.UncoventionalnaturalsourcesforfuturedrugdiscoveryJ.DrugDiscovToday20049450-458.6EmilienGMPonchonC.ImpactofgenomicsondrugdiscoveryandclinicalmedicineJ.QJMed2000937391-423.7WenJP.20058J.WorldBiotechnol2006223-25.8WangXHWangSQMaoBZ.J.20002711-5.9DingXS.J.AdvBioeng19991913-5.10VarmusH.TheneweraincancerresearchJ.Science200631257771162-1165.11RichieTLSaulA.ProgressandchallengesformalariavaceinesJ.Nature20024156872694-701.12GregorySGBarlowKFMclayKEetal.TheDNAsequenceandbiologicalannotationofhumanchromosome1J.Nature200644104727315-321.13JohanM.TheuseofgeneticstodissectplantsecondarypathwaysJ.CurrOpinPlantBiol200583230-235.14GaryW.Second-generationbiopharamaceuticalsJ.EurJPharmBiopharm2004582185-196.15ZhouB.21J.Chi-naPharm20041363-4.16LiYLHuangRQCuiYF.J.20043239-243.17AlomaABarhieriFCagnoliMetal.AntisenceoligomicleotidesastherapeuticagentsJ.PharmacolRes2003363171-178.18WuWTWangYTWuWJ.J.ChinJNatMed20042270-74.2007198520251664106028-314242100090258327147602583271366pharm@163.com2006744ChinJNatMedJuly2006Vol.4No.4!#
本文标题:生化药物的研究现状及发展思路
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