羟丙甲基纤维素在药剂学中的应用

1(,832002),7,;;TheapplicationofHPMCinpharmaceuticsQINDong2Mei,WANGHeng,LIHai2Ying(CollegeofParmacy,ShiheziUniversity,Shihezi832002)ABSTRACTAccordingtothecharacteristicsandqualitiesofHPMCdiscussitsfunctioninfromtablet,sustained2rdleasepreparation,controlled2releasepreparation,ophthalmicdrugdeliverysystem,suspension,hydogelandointmentsetc7dosageforms,thepaperintro2ducesapplicationofHPMCintherealmofpharmacyinrecentyears.KEYWORDSHPMC;preparation;application1,832002)(hydroxypropylmethylcellulose,HPMC),,m,(2000)2,HPMC2208,HPMCmMethcel(DOW)DHarmacoat()],110210,01101344,114HPMC-OCH3/%-OC3H6OH/%182816.520.023.032.0220819.024.04.012.0290627.030.04.07.5291028.030.07.012.0HPMC4,,,1,,202%(cst)1990,,19902208290629102C8H15O82(C10H18O6)n2C8H15O8,86000(),,2:C6H7O2(OH)3nnxNaOH+nxCH3Cl+nyC3H6O[(C6H7O2)(OH)32x2y(OCH3)x(OC3H6OH)ynHPMC:,60,,,,,,HPMC()4:,pH311,,,1%pH48,,,,:,,,,,HPMC,,11.11994,,HPMC,,,:40%5%(40%)1%(40%)3%HPMC10%3%HPMC,17134%28184%30184%8415%88%:12%1%HPMC(40%)2%HPMC(40%)3%HPMC(40%),80194%86123%90140%99188%:10%3%HPMC(40%),371AnhuiMedicalandPharmaceuticalJournal2004Jun;8(3)7612%97154%,HPMC,,,1.2,,,2%5%(014g+0108g)SMZ(80)40kg,(120)8kg,3%HPMC1820kg,013kg,TMP(80)8kg,SMZTMP,5min,3%HPMC,,16,,14,,96%/20minHPMC,(0125g)(80)25kg,(120)211kg,HPMC(100)017kg,20%11151215kg,,HPMC,20%,16,,14,,,80%/20min,1.3HPMC,(PVP),,,HPMC5,690,70%,2%4%,,,,,,HPMC,2HPMC,;,,,::HPMC;CMC2Na10125212512h,::HPMC;CMC2Na111251125;:HPMCCMC2Na12108219212h1,HPMCEC3(/=11),8pH,12h13gL-1,33.12250g10ml0101mol,90ml015gHPMC,,,60,3.2HPMC24000-4500-5000,013gNaCl0145gKCl0137g,0119g,10%0102ml,1000mlHPMC15ml,8090,35ml,40ml,,,,,,pH814816,4,015%115%,,5HPMC,,,;,;HPMC,1..:,2002;72,3,..:,19934..,1998;95.,1996;(3):2696.HPMC(),1997;5(:2003212229)()(CJA2CD),1999201212()(CAJ2CDB/T121998),20044,471AnhuiMedicalandPharmaceuticalJournal2004Jun;8(3)