莪术油的药理作用及临床用药的研究进展

ed.ByA.M.Michelson,J.M.McCordandI.Fridovich,Newyork:Academicpress,1997:12913814.SOD.,1994,15(4):28929415,,..,1989,10(1):565816,,.SOD.,1994,13(3):242817Naomik.,FujikoS.,KazudiO.,etal.Sensitiveenzymeim2munoassayforhumanCu/ZnsuperoxidedesmutaseClinicaChimicaActa.1990,(187)1:112018,,.Cu/Zn-SOD.:,,..4.:.1996:13914419,,.-6Cu,Zn-SOD.:..6.:.1998:10711420,..:.1994:10221Frederiks,WilmaM.,Bosch,klazinaS.Localizationofsuperoxidedesmutaseactivityinrattissues.FreeRadicalBiologyandMedicine.1997,22(1-2):241248(:2001-07-04;;2001-09-16)(325027):,,,::R285:A:1007-9939(2002)01-0012-021%1.5%,,-20[1],[2]11.1CA[3][4]AdV7AdV3,B,A0.04%10ml/(kgd)35d,10%1020u/(kgd)1015mg/(kgd),qd,35d,,(P0.05)1.2[5],,,,,,EaEt,1.3,[6],,,94.5%,117.9%,(P0.01)(P0.01)1.4,,,,1.5[7],,,22.12.1.1[8]150,70,98.42%,(2.50.5)d(93.70.5)d,212002121©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(P0.05)2.1.22.1.2.1[9],120,80802515,232730,P0.012.1.2.2[10]21,,21,,,,,2.1.2.3EB[11]EB,68,60,314d,4.9d,440d,12.5d,2.1.2.4[12]72,56,2.1.2.5[13]41,,,2487.8%447.06%,,,P0.012.1.2.6(HSK)[14]32HSK,2,2453,80.0%,90.6%2.1.2.7[15],(35)(36),,:,,(P0.01),,2.2[16](),,365.7%,45.1%(P0.05),Kamefsky,(P0105),,,2.3[17]72,38,15,8,11,,,49,97.22%2.4[18]35,5%2/d,,410214,88.6%,2.5[19]134,7,817222482.09%2.6[20]10,,0.3g/,3/d,,1,1687,,,;3,,1,,..2.,1998:8952..2000.2000:6973NigamS.S.CA,1970,73:63548114.,1999,18(3):1905,,,..,1997,4(2):296,,..,2000,17(3):1971997U.S.Dispensatory.24.1947:16528,,.150.,1995,15(5):179,.120.,1988,7(7):565710,.21.,1999,22(1):9211,.EB.,1998,11(4):23723812,..,1999,8(4):20320413,,..,1997,17(6):363364312002121©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(4);16816915,.35.,1999,21(2):115111616,..,1997,4(3):111217,,.72.,1998,18(6):3718,..,1998,3120:12412519,,,.134.,1999,19(4):282920..,1990,3(3):164165(;2001-04-29;:2001-07-10)1(518000;1518029)::R749.1:A:1007-9939(2002)01-0014-02,(Alzheimerddisease,AD),(NFT),ADAD11.1,AD,,ADAD,APPE(apoE)21(PS21)22(PS22)Scancchi2RapoEAD[1],apoE,[2]AD,apoE,(APP)21,670/671717AD21,AD14E4,AD,[3],Presenilin2(PS21)Presenilin22(PS22)[4],1.2AD,AD,Ach,2,,Ach[5]Ach,,ADAch[6],AD,52,,r2,[7]1.3AD,,[8],(Tau),APPIsohara2T(APPkinaseI)APP[9]ATP,,15O(PET)AD,40%50%[10][11]AD,412002121©1994-2007ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.