盐酸美金刚治疗帕金森痴呆患者的疗效观察

··。90904、8、12MMSEMoCA2Barthel22SPSS18．0。MMSE、MoCAP＞0．054、8、12MMSEMoCA2P＜0．0588．89%66．67%2P＜0．0517．78%20．00%2P＞0．05。。Ｒ742．5Ｒ749．16A1674-4152201505-0722-03TherapeuticeffectofmemantinehydrochlorideonparkinsonismdementiaFANWei-nvHONGWen-keGUANQiong-feng．DepartmentofNeurologytheSecondHospitalofNingboNingbo315010ZhejiangChinaAbstractObjectiveTostudyoftheutilityofmemantinehydrochlorideinimprovingcognitivefunctionanddailylifequalityofpatientswithparkinsonismdementia．MethodsAtotalof90patientswithparkinsonismdementiawereen-rolledandrandomlydividedintoobservationgroupandcontrolgroup．DonepezilhydrochloridetabletswereadministratedinthecontrolgroupwhileMemantinehydrochloridetabletsintheobservationgroup．On048and12weeksTheminimentalstateexaminationscaleMMSEandtheMontrealcognitiveassessmentscaleMoCAwereusedtoassessthementalstatusandcognitivefunctionofpatientsBarthelindexassessmentscalewasemployedtoevaluatedthedailylifea-bilityevaluationofpatientsafterthetreatment．Theincidenceofmedicineadversereactionsduringtheprocedurewasob-served．ThedatawasanalyzedbyusingSPSSsoftware．ＲesultsBeforethetreatmenttherewasnodifferenceinMoCAandMMSEscorebetweenthetwogroupP＞0．05．MMSEandMoCAscoreat48and12weekintheobservationgroupwerehigherthanthoseofthecontrolgroupandthedifferencewasstatisticalsignificanceP＜0．05．ThesatisfactionwithADLintheobservationgroupwas88．89%whichwasobviouslyhigherthan66．67%inthecontrolgroupthedifferencewasstatisticalsignificanceP＜0．05．Theincidencerateofadversedrugreactionintheobservationgroupwas17．78%whichwassimilarto20%inthecontrolgrouptherehadnostatisticalsignificancebetweenthetwogroupsP＞0．05．ConclusionMemantinehydrochloridecaneffectivelyimprovethecognitivefunctionanddailylifequalityofpatientswithparkinsonismdementia．Theclinicalcurativeeffectisobviouslyandisworthpopularizinginclinic．KeywordsMemantinehydrochlorideParkinsonCognitivefunctionDailylife1。[e-mail]2。N--D-13VentralHerniaWorkingGroupBreuingKButlerCEetal．Incision-alventralherniasreviewoftheliteratureandrecommendationsre-gardingthegradingandtechniqueofrepairJ．Surgery20101483544-558．14LiangMKLiLTNguyenMTetal．AbdominalreoperationandmeshexplantationfollowingopenventralherniarepairwithmeshJ．AmJSurg20142084670-676．2014-10-30·227·20155135ChineseJournalofGeneralPracticeMay2015Vol.13No.5。11.19045。222360～8270．2±3．22～146．8±2．128125212461～8370．3±3．12～146．7±2．027126。2、、、P＞0．05。。1.2①、《》3②③④⑤。1.3H10930198125mg/d2/d1125mg1g。H200509785mg/1/d410mg/1/d。H20062725mg/1/d110mg/1/d315mg/1/d420mg/1/d。212。、4、8、12MMSE、MoCA212Barthel2。1.4①MMSEMMSE10、3、5、395304。②MoCAMoCA、、、、、、、11、、、、、、8305。③BarthelBarthel、、、、、、、、10100＞6041～6021～40≤206。%=+/×100%。④2、、、。1.5SPSS18．0x±stχ2α=0．05。22.12MMSE2MMSEP＞0．054、8、12MMSE2P＜0．05。1。124、8、12MMSEx±s48124515．3±2．318．1±2．519．2±2．920．4±3．04515．6±2．116．2±2．317．3±2．518．4±2．9t0．64623．75193．32883．2154P0．51990．00030．00130．00182.22MoCA2Mo-CAP＞0．054、8、12MoCA2P＜0．05。2。224、8、12MoCAx±s48124516．5±1．919．2±2．620．6±2．722．4±2．94516．7±1．817．4±2．318．6±2．419．5±2．7t0．51263．47843．71394．9097P0．60950．00080．00040．00002.32Barthel88．89%66．67%2χ2=6．4286P=0．0112＜0．05。3。32n%452119324088．894512181053066．672.422、4、1、117．78%5、2、2·327·20155135ChineseJournalofGeneralPracticeMay2015Vol.13No.5、220．00%2χ2=0．0696P=0．7920＞0．05。3、、、7。8。、9。10。。11。。NMDANMDANMDA12。mＲNA13。14。NM-DA15。MMSEMoCA4、8、122P＜0．05。16MMSEADAS-cog16。。12Barthel2P＜0．05。17。P＞0．05。。1．J．201333204969-4970．2．J．201311136100-6102．3．J．201416185053-5054．4．J．2013193180-182185．5．J．201353150-53．6．J．201333194681-4685．7．J．2012389547-550．8．/β-N--L-J．2012203307-311．9．J．201220131-34．10．J．201395296-305．11．fMＲIJ．2013366517-519．12．J．201413213148-3150．13．J．2012195342-343．14．J．2012119928-932．15．J．2011182141-142．16．J．20121491001-1003．17．J．201411212794-2796．2014-11-07·427·20155135ChineseJournalofGeneralPracticeMay2015Vol.13No.5