唾液硝酸盐及亚硝酸盐研究进展

:100050##夏登胜王松灵,98%,,,,,NO[1],11:[2]Bos[3]1988,1991CortasWakid[4],,21:,,1010CFU/L,20%,80%[5]1.:98%,25%CortasWakid[4]53~5h,40mg/kg,,:1025,60240,9,,,,20%,3:¹,,,yyy,,80%[2];º,,,;»,,60%~70%24~48h;(10%)(015%),25%21:(1)NOZetterquist[6]1012h,400mg,NO,NO,120min,,,NO,(2):,;,,11:SpiegelhalderTannenbaum[7,8],2.:Cingi[2]100,,Murdia[9],Bos[3]CE31:,:#474#200111366ChinJStomatol,November2001,Vol36,No.6(1)pH:pH,,;pH810,[9](2):pH,Zetterquist[6]VanMaanen[10]NO012%NO50%;10%NO,,(),[11]41:Granli[12],,53%,59%,118%,+41%;88%,600%(4):,,[2]1.:(1):,,)N-Badawi[13],3[14](2):,,WHO45mg/L,50mg/L2.:(1):WolffWasserman[15],Dougall[16],,,(2)NO:,NO,NO,;NO,,[1]McKnight[17]10NO,,NO,NO,Duncan[18],,NO,NO,,;,[19]1McKnightGM,DuncanCW,LeifertC,etal.Dietarynitrateinman:friendorfoe?BrJNutr,1999,81:349-358.2CingiMI,CingiC,CingiE.Influenceofdiaterynitrateonnitritelevelofhumansaliva.BullEnvironContamToxicol,1992,48:83-88.3BosPM,vandenBrandtPA,WedelPA,etal.Thereproducibilityoftheconversionofnitratetonitriteinhumansalivaafteranitrateload.FoodChem,Toxicol,1988,26:93-97.4CortasNK,WakidNW.Pharmacokineticaspectsofinorganicnitrateingestioninman.PharmacolToxicol,1991,68:192-195.5MirvishSS.Theetiologyofgastriccancer.Intragastricnitrosamideformationandothertheories.JNatlCancerinInst,1983,71:629-647.6ZetterquistW,PedrolettiC,LundbergJO,etal.Salivarycontributiontoexhalednitricoxide.EurRespirJ,1999,13:327-333.7SpiegelhalderB,EisenbrandG,PreussmannR.Influenceofdietarynitrateonnitriteconcentofhumansaliva:possiblerelevancetoinvivoformationofN-nitrosocompounds.FoodCosmetToxicol,1976,14:545-548.8TannenbaumSR,WeissmanM,FettD.Theeffectofnitratein-takeonnitriteformationinhumansaliva.FoodCosmetToxicol,1976,14:549-552.9MurdiaUS,MehtaFJ,BhideSV.Nitratereductaseactivityandnitritelevelsinthesalivaofhabitualusersofvarioustobaccoproducts.FoodChemToxicol,1982,20:269-271.10VanMaanenJM,PachenDM,DallingaJW,etal.Formationofnitrosaminesduringconsumptionofnitrate-andamine-richfoods,andtheinfluenceoftheuseofmouthwashes.CancerDetectPrev,1998,22:204-212.11ShapiroKB,HotchkissJH,RoeDA.Quantitativerelationshipbetween#475#200111366ChinJStomatol,November2001,Vol36,No.6oralnitrate-reducingactivityandtheendogenousformationofN-nitrosoaminoacidsinhumans.FoodChemToxicol,1991,71:751-755.12GranliT,DahlR,BrodinP,etal.Nitrateandnitriteconcentrationinhumansaliva:variationswithsalivaryflow-rate.FoodChemToxicol,1989,27:675-680.13BadawiAF,HosnyG,e-lHadaryM,etal.Salivarynitrate,nitriteandnitratereductaseactivityinrelationtoriskoforalcancerinEgypt.DisMarkers,1998,14:91-97.14..,1986,8:53-57.15WolffIA,WassermanAE.Nitrates,nitrites,andnitrosamines.Science,1972,177:15-19.16DougallHT,SmithL,DuncanC,etal.Theeffectofamoxycillinonsalivarynitriteconcentration:animportantmechanismofadversereactions?BrJClinPharmacol,1995,39:460-462.17McKnightGM,SmithLM,DrummondRS,etal.Chemicalsynthesisofnitricoxideinthestomachfromdietarynitrateinhumans.Gut,1997,40:211-214.18DuncanC,DougallH,JohnstonP,etal.Chemicalgenerationofnitricoxideinthemouthfromtheenterosalivarycirculationofdietarynitrate.NatMed,1995,1:546-551.19,,..,1999,34:96-98.(:2000-03-15)(:):310003,();()##关节盘移位后双板区弹力纤维的适应性变化谷志远刘建华吴慧玲曹之强胡济安(elasticfiber,EF),,,EFEF11:26,210~215kg,2,2424681012421:3%(114ml/kg),,,,2~3mm,,,1,31:,,10%,EDTA,,-,EF,EF,;EF,;EF;EF,,,EF;EF2,EF,,;4,,,,EF;6,,;8,,;101282EF,;4,,;8,EF,EF,EF,8EFEF,,,;,,EF,,,,;EF,EF,EF,EF,EF,6,EF,(:2000-05-26)(:)#476#200111366ChinJStomatol,November2001,Vol36,No.6