丝瓜根提取物的安全性及抗炎作用研究

【】。。、。。。。【】StudiesonsafetyandAnti-inflammatoryActionforextractsinrootofLuffacylindricalTANGGui-xinLIAOWei-ming.TANGAi-lianetal.GuilinMedicalUniversityGuilinGuangxi541004China【Abstract】ObjectiveTotestthesafetyandanti-inflammatoryactionofextractsinrootofLuffacylin-drical.MethodsThesafetyofLuffacylindricalwastestedbyskinacutetoxicityexperimentskinirritationex-perimentandacutetoxicityexperiment.Theanti-inflammatoryactionwasstudiedbythroughxylene-inducedmouseauricleswellingexperimentandcarrageena-inducedmousepawswellingexperiment.ResultsNoirrita-tionreactionoccurredincompleteskinafterappliedNiushangLinglinimentmanytimesandnoreactionsofoc-curredininjuredskin.AndtheMTDislarge.Thedrugcouldobviouslyinhibitxylene-inducedmouseauricleswellingandcarrageena-inducedratpawswelling.ConclusionTheresultsindicatedthatthedrugissafeandhasobviousanti-inflammatoryeffects.【Keywords】LuffacylindricalrootSafetyAnti-inflammatoryActionLuffacylindricaL.Roem。、、1。116L-cy-121β-L-cy-23-O-β-D--21β-L-cy-32α--3-O-β-D-L-cy-622α-3-O-β-D--L-cy-72α-3-O-β-D-28-O-D--L-cy-83。。11.11.1g/mlSigma。1.218～23gWistar160～200g6280～320g。。22.12.1.1201024h40cm224h2.8g/ml8#“#”47d。、、、、、、。。2.8g/ml。2.1.22021024h20cm224h2.8g/ml0.5ml。8#“#”3。24h1、24、48、72h。5。1。1n=51h24h48h72h00000.500000.500000.500000.52002316541004·8·2010142ChinJModDrugApplJan2010Vol.4No.2=+000.5。000.5。。2.1.30.4ml/10gLD50。。200.4ml/10g110g/kg7d。。。2.22.2.14528～32g5、、8h3。1h0.05ml。2h8.5mm。。2。2x±sn=9g/kgmgP226.37±4.640.01114.41±6.330.015.52.84±3.210.012.5mg4.88±3.730.01-15.00±7.60-。2.2.2204、8h3。1h1%0.1ml0.5、1、2、4、6hml%。3。3x±sn=5g/kg%0.5h1h2h4h6h2222.8±8.433.3±13.448.5±6.946.6±14.446.7±13.41115.7±14.434.9±10.931.9±9.323.0±12.0*26.5±9.22.5mg9.8±11.915.5±9.211.7±9.224.6±6.9*16.1±6.6-24.2±11.942.6±14.041.8±5.038.5±8.528.1±12.8P0.01*P0.0511g/kg4h。32.8g/ml110g/kg。11g/kg4h。。1《》...1976308-309.2..2001329773-775.3.П.200821417-18.4.199811522.5.1993205.·9·2010142ChinJModDrugApplJan2010Vol.4No.2