新型药物载体的研究与开发

朱子春1,2,光洁3,陈建兵1,2(1.,247000;2.,247000;3.,201203):,,,;,:;;:R73-36+2:A:1005-8141(2008)06-0492-03DevelopmentandApplicationofNewDrugDeliverySystemZHUZi-chun1,2,GUANGJie3,CHENJian-bing1,2(1.DepartmentofChemistryandFoodScience,ChizhouCollege,Chizhou247000,China;2.CentreofEngineerigMaterials,InstituteofNon-metalMineralsIndustry,Chizhou247000,China;3.ShanghaiChempartnertCO.LTD,Shanghai201203,China)Abstract:Byadsorption,wrappingandcoalescent,drugdeliverysystemcouldeffectivelydeliverthedrugtoatargetsiteandincreasedthebioavailability,therapeuticbenefit,withminizingthenegativesides.Theapplicantionofnanoparticles,liposomeusedasnovelkindsoftargetingdrugsdeliverysystemswereintroducedinthetext,anddiscussedthedevelopmentofdrugdeliverysysteminthefuture.Keywords:drugdeliverysystem;nanoparticles;liposome:2008-04-11;:2008-05-19:;(:KJ2006B156;XK0824;KJ2008B177):(1981-),,,,1,,,:;,,;,;,;;,;;,;,[1]2,O/W[2],O/W;,;,,,,[3](nanoparticles,NP),,,,2.1,,,,NP,,NP,,,,,,So-ma[4],;Yoo[5],)#492###ResourceDevelopment&Market200824(6),),,,,,:¹,,40)45e,[6,7]º,/,,,»,,¼,,,,,,,,,,,,,,[8-10],,,,;,,))),,,,[11,12],NP,NP,NP,NP,,,[13,14],2.250)1000nm,,,pH,,:,,,;,,;,,[15,16](solidlipidnanoparticles,SLN)[2]2090,,,,50)1000nm,,,,,SLN,,,3,;,,[17]0.2mg/ml#493#ResourceDevelopment&Market200824(6)##,,8(elec-troretinogram,ERG),,,ERG;[18],,,0.2mg/ml8,,,2.3,,;,(PLA)(PGA)(PLGA);,(PCPP)SA)(PFAD)SA);,,[19,20],FDADL)PLA(),,(Tg)65e,,PLACO2H2O,,,2050PLA,[19-21]Negrin[20]PLA,65%,1,200ng/ml,1Baro[21](Mw=30000),,,,,,,,,Tetz[22],8:54.6mg,28.6mg,64.1mg,Duncan[21],(200ng/ml),;(2mg/ml),,[23-25]3,,,,,,,,,,,,:[1],.[J].,2004,21(7)B502-504.[2]LIXin-wei,ZHANGLi-qiang,etal.SolidLipidNanoparticlesasDrugDe-liverySystem.[J].ProgressInChemistry.2007,19(1)B87-92.[3]LISai,LIUXiao-bo.DevelopmentofPolymericNanoparticlesintheTarget-ingDrugsCarriers[J].BiomedEng,2004,21(3)B495-497.[4]SomaCE,DubernetC,BarattG,etal.AbilityofDoxorubicin-loaded-nanoparticlestoOvercomemultidrugResistanceofTumorCellsAfterTheir-capturebyMacrophages[J].PharmResearch,1999,16(11)B1710-1716.[5]YooHS,ParkTG.InvitroandinVivoAntitumorActivitiesofNanopar-ticlesBasedonDoxorubicin-PLGAConjugates[J].PolymPrer,2000,41(1)B992-993.(570)#494###ResourceDevelopment&Market200824(6)3.4,,,,,/0,,,,/0,,,,,,,,3.5,,,,,,,,,,,(),,,(),4,,,,:[1](12006218)[EB/OL].[2].29[EB/OL].[3].[J].,2005,(10)B52-53.(494)[6]ZhangJianhong,LiuJunfeng,LiWei.StudyonSynthesisandPerformanceofMagneticFe3O4inNanometerCcale[J].NewChemicalMaterials,2004,32(3)B20-22.[7]AlexionC,AmoldW,KleinRJ,etal.LocoregionalCancerTreatmentwithMagneticDrugTargeting[J].CancerResearch,2000,60(23)B6641-6648.[8],,.[M].:,2000B31.[9]KuboT,SugitaT,ScimoseS,etal.TargetedSystemicchemotherapyUsingMagneticLiposomeswithIncorpo-ratedAdriamycinforOsteosarcomainHamsters[J].IntJOncol,2001,18(1)B121.[10]L™bbeAS,AlexiouC,BergemannC.ClinicalApplicationsofMagneticDrugTargeting[J].JSurgRes,2001,95(2)B200.[11]AlexiouC,JurgonsR,SchmidR,etal.InVitroandInvivoInvestigationsofTargetedChemotherapywithMag-neticNanoparticles[J].JMagnMagnMater,2005,293(1)B389.[12]TorchilinVP.Polymer-coatedLong-circulatingMicroparticulatePharma-ceuticals[J].JMicroencapsulation,1998,15(1)B1.[13]DuvvuriS.DevelopmentofaAovelFormulationcontainingPoly(D,L-lactideCoglycolide)MicrospheresDispersedinPLGA-PEG-PLGAGelforSus-tainedDeliveryofGanciclovir[J].ControlledRelease,2005,108(2-3)B282.[14]YiaoMX.InjectableBiodegradableTemperature-responsivePLGA-PEG-PLGAcopolymers:SynthesisandEffectofCopolymerCompositionontheDrugReleasefromtheCopolymer-basedHydrogels[J].IntJPharm,2005,294(1-2)B103.[15]BanerjeeR.Liposomes:ApplicationsinMedicine[J].JBiomater,2001,16(1)B3-21.[16]LianT,HoRJl.TrendsandDevelopmentsinLiposomeDrugDeliverySys-tems[J].JPharmSci,2001,90(6)B667-680.[17]MingxingWu,HuamingLi,ShaozhenLi.TheEffectofLiposomeEn-capsu-latedDaunorubicinonRabbitEyesafterExtracapsularLensExtraction[J].YanKeXueBao,2000,16(3)B189-193.[18],.[J].,1996,13(3-4)B51-54.[19]OkadaH,ToguchiH.BiodegradableMicrospheresinDrugDelivery[J].CritRevTherDrugCarrierSyst,1995,12(1)B1-99.[20]NegrinCM,DelgadoA,LlabresM.MethadoneImplantsforMethadoneMaintenanceTreatment.InVitroandinVivoAnimalStudies[J].JCon-trolledRelease,2004,95(3)B413-421.[21]BaroM,SanchezE,DelgadoA,etal.InVitro-inVivoCharacterizationofGentamicinBoneImplants[J].JControlledRelease,2002,83(3)B353-364.[22]TetzMR,RiesMW,LucasC,etal.InhibitionofPosteriorCapsuleOpacif-icationbyanIntraocular-lens-boundSustainedDrugDeliverySystemBAnExperimentalAnimalStudyandLiterature[J].JCataractRefractSurg,1996,22(8)B1070-1078.[23]DuncanG,WormstoneIM,LiuCS,etal.Thapsigargin-coatedIntraocularLensesInhibitHumanLensCellGrowth[J].NatMed,1997,3(9)B1026-1028.[24]PandeySK,CochenerB,AppleDJ,etal.IntracapsularRingSustained5-fluorouracilDeliverySystemforthePreventionofPosteriorcapsuleOpacifica-tioninRabbits:AHistologicalStudy[J].JCataractRefractSurg,2002,28(1)B139-148.[25]WadoodAC,ArmbrechtAM,AspinallPA,etal.SafetyandEfficacyofaDex-amethasoneAnter