膜分离技术在中药提取与制剂研究中的应用

,,1(,250014;11,100102):,,,,::R28412:A:1672-7738(2008)04-0226-03ApplicationsofmembraneseparationtechnologyinextractionandpreparationoftraditionalChinesemedicineSUNFu2dong,WANGShu2ling,WANGYing2zi1(ShandongUniversityofTraditionalChineseMedicine,Jinan250014;11BeijingUniversityofTraditionalChineseMedicine,Beijing100102)ABSTRACT:BasedonthecomparisonwithconventionaltechnologyofseparationandextractionoftraditionalChinesemed2icine,membraneseparationtechnologyexhibitedoutstandingadvantageofhighefficiency,simpleoperation,lowenergycon2sumptionandenvironmentally2benignancy1ThestatusofultrafiltrationapplicationsinextractionoftraditionalChinesemedicinewasreviewed,includingextractionoftheeffectivecomponents,preparationofinjection,oralliquidandliquidextract,etc1Inad2dition,meritsanddemeritsoftheseparationtechnology,andsomepossiblewaystoovercomethedemeritsofmembranesepara2tionwerediscussed1Thefuturestudywasalsopointedoutforseparationoperation1KEYWORDS:TraditionalChinesemedicine;extraction;preparation;membraneseparation20,,,1(MST),(),,:,;();;,,(MF)(UF)(NF)(RO)[1](MPa)(MF)01110m,0105015(UF)550nm,,011110(NF)0155nm,,0155,,(RO)011110nm,,110102,1000,50000,,:,[2],622QiluPharmaceuticalAffairs2008Vol127,No146000,,3,9315%,8713%6417%,5213%[3]10000,2113%3912%,[4](),,[5],,5,,,;,,,,[6],,,,,,3[7],1000030000,,6000,,,,5%1%,,[8]CO2,,6000,,2000[9],[10],[11],[12]4[13]5,,,,,,,[14],,610715,,,[15],[16],,5[17],:;100%;,;[18],:,,;6,,,5,,[19]1,7[20]711,,1000,1000,,,,,,,,,,,,712pHpH,pH,pH,pH,713,,,,,,103106,103106103,,,;722QiluPharmaceuticalAffairs2008Vol127,No14;,,,,[21]10,,,714,,,,,,,,,,,,,,715,,,,,,,,,,,,,,,,,,,,[1],,11,2006,32(3):11141[2],11,2003,24(4):56581[3],,,11,2004,21(2):1121141[4],,,11,2003,18(2):76811[5],,,11,2003,25(1):17191[6]11CN1476892,20041[7],,,11,2002,24(2):1371391[8],1CO2-1,2002,22(10):5815821[9],,1111988,19(9):16171[10],,11,1990,12(1):341[11],,,11,1991,(1):141[12],11,1993,11(4):451[13],,11,1992,15(2):30321[14],,11,1996,27(4):2092111[15]11,2000,26(1):221[16]11,2000,11(1):251[17],11,1988,(11):411[18],,,11,2002,27(3):2302311[19]11,1999,15(2):861[20]11,2004,6(2):31341[21],,,11(),2002,18(6):3391FDA2008228,FDANexium(esomeprazolemagnesium,)111,10mg20mg,Nexium,,FDANexium,,109111Nexium,8,8:822QiluPharmaceuticalAffairs2008Vol127,No14