胃内微生态与胃癌关系研究进展

[e-mail]。doi∶10．3969/j.issn.2095－1736．2016.03.08011121．2120022．212002。HelicobacterpyloriHp。Hp、。。Hp、、Hp、。。R735．2A2095－1736201603－0080－03ProgressoftherelationshipbetweenmicrobialfloraandgastriccancerXUGuo-qiang1ZHANGYou-li1YUANYing-xue1WANGWen-bing21．DepartmentofGastroenterologyAffiliatedHospitalofJiangsuUniversityZhenjiang2120022．InstituteofLifeSciencesJiangsuUniversityZhenjiang212002ChinaAbstractGastriccancerisacommondigestivesystemcancerworldwide．HelicobacterpyloriHpinfection-relatedgastritisisama-jorriskfactorforgastriccanceroccurence．TheriskofgastriccanceroccuringinHpinfectionisrelatedtothefactorsofmicrobialflorainthestomachimmunefunctionandenvironment．Inrecentyearsstudiesfoundthatgastrointestinalmicro-ecologyiscloselyassociat-edwithgastriccancerdevelopment．Inthispaperthefollowingseveralaspectstogastriccancerwerediscussedincludingtherelation-shipbetweenHpandcancerofthestomachthestomachmicroecologicalchangeincancerrolesofthestomachmicroecologyinthecancerdevelopmentaswellaswiththeinteractionbetweenHpandprobioticsforthecancerprevention．Therolesofmicroenvironmentingastriccancerwereanalyzedforreferencefortheclinicaltreatmentofthedisease．KeywordsgastriccancerHelicobacterpylorimicrobialflora140302。、、。、、。、。。。1HpHp、、、3HpⅠ4。“→→→→”Hp5。HpACagAAVag-A。Teng6Hplet-7bTLR4NF-κBCOX-2CyclinD10833320166JOURNALOFBIOLOGYVol.33No.3Jun2016let-7bTLR4MyD88NF-kBHp。HpCagAmiR-320Mcl-17。Hayashi8HpcagAc-mycDNAZestehomologue2en-hancerofzestehomologue2EZH2DNAlet-7Ras。2。。。。。Bik912885、、、。Dicksved101051025、、、Hp、。Aviles-Jimenez11、、、Lactobacilluscoleohominis、PseudomonasaeruginosaLachnospiraBryantandSmall→→。3。、、、Ⅰ。。Orlando12GGL．rhamnosusstrainGGL．GGHGC-27DLD-1。Cousin13PropionibacteriumfreudenreichiiHGT-1、、、C、DNA、。。Hwang14L．caseiKATO3NF-κBKATO3。NF-κBIκBmTORPI3KAktp70S6。74－2、-420AGSNCI-N87PT-PCR-1COX-1、COX-2、COX-1－IRNCI-N87COX-1COX-115。、HpIL-10TNF-α16。Ziebarth17N-。4HpHpHp。INS-GASHpHp8HpHp1222Hp。Hp。HpHp18。Rolig19Clostridiumspp．CD4+THp。Lofgren20INS-GASINS-GAS1833320166JOURNALOFBIOLOGYVol.33No.3Jun2016。HpHp。Mowat21HppHHpN-。Hp。Lertpiriyapong22INS-GAS、、、HpINS-GASAlteredSchaedler'sflo-raASF。Hp。、3HpHp23。HpHp、、Hp。5。、。。Hp24。25。2613。6。、、。1KIMMJKIMH．Anticancereffectoflycopeneingastriccarcino-genesisJ．JCancerPrev201520292－96．2ZOUXSUNXCHENWetal．Analysisofincidenceandmortali-tyofstomachcancerinChinafrom2003to2007J．Tumor2012322109－114．3TAKEUCHIKOHNOYTSUZUKIYetal．HelicobacterpyloriinfectionandearlygastriccancerJ．JournalofClinicalGastroen-terology2003364321－324．4MITCHELLHM．TheepidemiologyofHelicobacterpyloriJ．CurrTopMicrobiolImmunol199924111－30．5WEBBPMLAWMVARGHESECetal．GastriccancerandHe-licobacterpyloriacombinedanalysisof12casecontrolstudiesnes-tedwithinprospectivecohortsJ．Gut2001493347－353．6TENGGGWANGWHDAIYetal．Let-7bisinvolvedintheinflammationandimmuneresponsesassociatedwithHelicobacterpylo-riinfectionbytargetingToll-likereceptor4J．PloSone20138256709．7NOTOJMPIAZUELOMBCHATURVEDIRetal．Strain-spe-cificsuppressionofmicroRNA-320bycarcinogenicHelicobacterpyloripromotesexpressionoftheantiapoptoticproteinMcl-1J．AmericanJournalofPhysiology-GastrointestinalandLiverPhysiology201330511786－796．8HAYASHIYTSUJIIMWANGJetal．CagAmediatesepigeneticregulationtoattenuatelet-7expressioninHelicobacterpylori-relatedcarcinogenesisJ．Gut201362111536－1546．9BIKEMECKBURGPBGILLSRetal．MolecularanalysisofthebacterialmicrobiotainthehumanstomachJ．ProcNatlAcadSciUSA20061033732－737．10DICKSVEDJLINDBERGMROSENQUISTMetal．MolecularcharacterizationofthestomachmicrobiotainpatientswithgastriccancerandincontrolsJ．JournalofMedicalMicrobiology2009584509－516．11AVILES-JIMENEZFVAZQUEZ-JIMENEZFMEDRANO-GUZ-MANRetal．Stomachmicrobiotacompositionvariesbetweenpa-tientswithnon-atrophicgastritisandpatientswithintestinaltypeofgastriccancerJ．ScientificReports201444202．12ORLANDOAMESSACLINSALATAMetal．EffectsofLacto-bacillusrhamnosusGGonproliferationandpolyaminemetabolisminHGC-27humangastricandDLD-1coloniccancercelllinesJ．ImmunopharmacologyandImmunotoxicology2009311108－116．13COUSINFJJOUAN-LANHOUETSDIMANCHE-BOITRELMTetal．MilkfermentedbyPropionibacteriumfreudenreichiiin-ducesapoptosisofHGT-1humangastriccancercellsJ．PLoSOne20127331892．872833320166JOURNALOFBIOLOGYVol.33No.3Jun2016byTLR7inthelysosomesofconventionaldendriticcellsJ．NatImmu-nol2009106587－594．19TANJIHOHTOUSHIBATATetal．StructuralreorganizationoftheToll-likereceptor8dimerinducedbyagonisticligandsJ．Science201333961261426－1429．20REGANTNALLYKCARMODYRetal．IdentificationofTLR10asakeymediatoroftheinflammatoryresponsetoListeriamonocytogenesinintestinalepithelialcellsandmacrophagesJ．JImmunol2013191126084－6092．21OOSTINGMCHENGSCBOLSCHERJMetal．HumanTLR10isananti-inflammatorypattern-recognitionreceptorJ．ProcNatlAcadSciUSA2014111424478－4484．22KOBLANSKYAAJANKOVICDOHHetal．RecognitionofprofilinbyToll-likereceptor12iscriticalforhostresistancetoToxoplasmagon-diiJ．Immunity2013381119－130．23OLDENBURGMKRUG