叶酸化合物的修饰

Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.1/132015-11-0603:31:45NNHNHNOONHH2NNHOO–OOO–Ca2+NNNHHNOONHH2NNHOOO–OO–HCa2+11.11.21.3HNNNHHNOH2NNHNHOOHOHOOHONNHNNHON+H2NHNOOHOOHOHCl–NNHNNHON+H2NHNOOHOOHOHCl–523OHOHHNNNHHNOH2NNHNHOOHOHOOHOHOHNOONHNHNONHH2NNHOOHOHOO5.15.24NNNHNOH2NNHNHOOHOHOOHH2NNHNNHONH2H2NHNHNOOHOOHOHNNNHHNOH2NNHNHOOHOHOOHOClO6NNHNNHOOONH2HNHNHNOOHOOHO7NHNNHNOOONH2NHNOOHNOOHOOHO8NHOHOONH2HOOHNHNNHNOOONH2NOOO9NHNNHNOOONH2NHOOOCopyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.2/132015-11-0603:31:451.1HNNNHHNOH2NNHNHOOHOHOOHONNHNHNOHNH2NHNOOO–OO–Ca2+NNNHHNOONHH2NNHOOO–OO–HCa2+Rx-ID:35425053YieldConditions&References42.7%Stage1:Withsodiumhydroxideinwater,Time=0.5h,pH=9Stage2:Withpotassiumborohydrideinwater,Time=4h,T=15°C,pH=9Zhou,Minghao;Hong,Mei;Xiao,Guomin;ResearchonChemicalIntermediates;vol.39;nb.5;(2013);p.2211-2218Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.3/132015-11-0603:31:451.2HNNNHHNOH2NNHNHOOHOHOOHOHOHNNHNNHON+H2NHNOOHOOHOHCl–Rx-ID:1453645YieldConditions&References84%Withhydrogenchloride,Time=12h,T=25°CKuge,Yukihiro;Inoue,Kunimi;Ando,Kyoji;Eguchi,Tamotsu;Oshiro,Takashi;etal.;JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999);nb.11;(1994);p.1427-143224%Withhydrogenchlorideinwater,trifluoroaceticacid,Time=14h,AmbienttemperatureRees,Lilias;Valente,Edward;Suckling,ColinJ.;Wood,HamishC.S.;Tetrahedron;vol.42;nb.1;(1986);p.117-136Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.4/132015-11-0603:31:451.3OHOHNOONHNHNONHH2NNHOOHOHOONNHNNHON+H2NHNOOHOOHOHCl–Rx-ID:1693902YieldConditions&ReferencesWithhydrogenchloride,hydrogenbromide,1)52degC,2.5hOwens,Jonathan;Rees,Lilias;Suckling,ColinJ.;Wood,HamishC.S.;JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999);nb.7;(1993);p.871-876Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.5/132015-11-0603:31:452HNNNHHNOH2NNHNHOOHOHOOHOHOHNNHNNHON+H2NHNOOHOOHOHCl–Rx-ID:1453645YieldConditions&References84%Withhydrogenchloride,Time=12h,T=25°CKuge,Yukihiro;Inoue,Kunimi;Ando,Kyoji;Eguchi,Tamotsu;Oshiro,Takashi;etal.;JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999);nb.11;(1994);p.1427-143224%Withhydrogenchlorideinwater,trifluoroaceticacid,Time=14h,AmbienttemperatureRees,Lilias;Valente,Edward;Suckling,ColinJ.;Wood,HamishC.S.;Tetrahedron;vol.42;nb.1;(1986);p.117-136Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.6/132015-11-0603:31:453OHOHNOONHNHNONHH2NNHOOHOHOONNHNNHON+H2NHNOOHOOHOHCl–Rx-ID:1693902YieldConditions&ReferencesWithhydrogenchloride,hydrogenbromide,1)52degC,2.5hOwens,Jonathan;Rees,Lilias;Suckling,ColinJ.;Wood,HamishC.S.;JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999);nb.7;(1993);p.871-876Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.7/132015-11-0603:31:454HNNNHHNOH2NNHNHOOHOHOOHOClONOONHNHNONHH2NNHOOHOHOONOONHNHNONHH2NNHOOHOHOORx-ID:1453635YieldConditions&Referencesinethanol,Time=21.5h,Ambienttemperature,pH7,Yieldgiven.YieldsofbyproductgivenOwens,Jonathan;Rees,Lilias;Suckling,ColinJ.;Wood,HamishC.S.;JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999);nb.7;(1993);p.871-876pH=7;thenbutan-1-olextractionRees;Suckling;Wood;JournaloftheChemicalSociety-SeriesChemicalCommunications;vol.No.6;(1987);p.470-472Copyright©2015ReedElsevierPropertiesSA.Allrightsreserved.Authorizeduseonly.Reaxys®andtheReaxys®trademarkareownedandprotectedbyReedElsevierPropertiesSAandusedunderlicense.8/132015-11-0603:31:455.1NNNHNOH2NNHNHOOHOHOOHHNNNHHNOH2NNHNHOOHOHOOHHNNNHHNOH2NNHNHOOHOHOORx-ID:8738249YieldConditions&ReferencesWithhydrogen,silicagel,(2S,4S)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]-1-(tert-bu-toxycarbonyl)pyrrolidine,[RhCl(η2:η2-cycloocta-1,5-diene)]2inphosphatebuffer,Time=24h,T=80°C,p=37503Torr,pH=7.0,Productdistribution,FurtherVariations:ReagentsBrunner,Henri;Rosenboem,Sabine;MonatsheftefurChemie;vol.131;nb.12;(2000);p.1371-1382ExampleNameD7DHydrogenationsinAqueousReactionMediumExamplesD1-D80.0025mmoleofligandisdissolvedin5mlofwaterand0.5mlofpH7buffer(0.041moleofNa2HPO4and0.028mmoleofKH2PO4in1lofwater).Thecarboxylicacidgroupsof