纳米药物载体在肿瘤治疗中的应用

©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.×Ø,,210002Applicationofnano2scaledrugvehiclesincancertherapyZHANGShi2xin,LIFang2qiuInstituteofMedicalLaboratoryScienceofPLA,NanjingGeneralHospitalofNanjingMilitaryCommand,Nanjing210002,P.R.China::(CNKI),,2000-200934;PubMednano,cancer540,28:,,,:,,2010,17(13):1031-1034[ABSTRACT]OBJECTIVE:Toreviewtheapplicationofnano2scaledrugvehiclesincancertherapy.METHODS:Atotalof34articleswerefoundinCNKIdatabasefrom2000to2009,and540articlesinPubMeddatabaseuptonow,withnano,canceraskeywords.Thearticlesaboutnano2scaledrugvehiclesandcancerwereselected,and28relatedpaperswereusedintheanalysisatlast.RESULTS:Nano2scaledrugvehiclesareabletocarrytheirloadedactivedrugstothetumorbytargetingmechanism.Moreo2ver,nano2scaledrugvehiclesaresuitedforcontrollingandcoor2dinatingthepharmacokineticsofco2administereddrugssothatthedesiredratiocanbemaintainedinvivo,improvingbioavail2abilityandprolongingthetimeofdrugaction.CONCLUSION:Multifunctionalandmultiplexnanoparticlesarenowbeingactive2lyinvestigatedandareonthehorizonasthenextgenerationofnanoparticles,facilitatingthepersonalizedcancertreatment.ChinJCancerPrevTreat,2010,17(13):1031-1034;;;[KEYWORDS]nano2scaledrugvehicles;tumor;targeting;reviewliteratureR730.5A1673-5269(2010)13-1031-04,,[1],,,[2],,(30670599),,,,Tel:[phone]E2mail:[e-mail],,,,,Tel:[phone]E2mail:[e-mail],[3],,,,13200nm,1.11.1.11301201071713CHINJCANCERPREVTREAT,July2010,Vol.17No.13©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(1A),DNA,,()[4](N222hydroxypropyl2methacrylamidecopol2ymer,HPMA)(polyethyleneglycol,PEG)(poly2L2glutamicacid,PGA),,PGA2[5]1.1.2(1B),,[6],,,[7],1.1.3(1C),,1.2(1D),,,[8],[9],AIDS1.3(1E)(),()[10]()(),1.4(1F),DNA,,,(B)(),[11],,1A:;B:;C:;D:;E:;F:2,(),[12]2301,©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.()Kuffer150200nm,100600nm,2nm,100150nm,,[13],(PEG),,[14],,2.1,()[15],,,50103(),,,pH7.4,(),2.2(2),[16],,,2,,(),,53%[17],,22,(2)3,P2(P2glycoprotein,P2gp)(lungresistanceprotein,LRP)ABCG4(ATP2(ATP2bindingcas2sette,ABC)7G4)[18219],P2gp,ATP,P2gp,P2gp,[20],,P2gp,,P2gp,,100nm(60),[21],,[22],,,,[23],,,,4,,[24],,([25][26]),,,3301201071713CHINJCANCERPREVTREAT,July2010,Vol.17No.13©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[1]RossJS,SlodkowskaEA,SymmansWF,etal.TheHER22receptorandbreastcancer:tenyearsoftargetedanti2HER22therapyandpersonalizedmedicine[J].Oncologist,2009,14(4):3202368.[2].[J].,2008,15(5):4012405.[3]KristineMG,KarlaFS,LawrenceEM,etal.Cytotoxicityandreactiveoxygenspeciesgenerationfromaggregatedcarbonandcarbonaceousnanoparticulatematerials[J].IntJNanomedi2cine,2008,3(1):83294.[4]GradisharWJ,TjulandinS,DavidsonN,etal.Phasetrialofnanoparticlealbumin2boundpaclitaxelcomparedwithpolyeth2ylatedcastoroil2basedpaclitaxelinwomenwithbreastcancer[J].JClinOncol,2005,23(6):779427803.[5]SabbatiniP,AghajanianC,DizonD,etal.PhasestudyofCT22103inpatientswithrecurrentepithelialovarian,fallopiantube,orprimaryperitonealcarcinoma[J].JClinOncol,2004,22(22):452324531.[6]TalelliM,RijckenCJ,LammersT,etal.Superparamagnetici2ronoxidenanoparticlesencapsulatedinbiodegradablethermosen2sitivepolymericmicelles:towardatargetednanomedicinesuit2ableforimage2guideddrugdelivery[J].Langmuir,2009,25(4):206022067.[7],,.[J].,2008,33(16):193621940.[8],.[J].,2007,14(22):174021743.[9]CortesJ,CosimoSD,ClimentMA,etal.Nonpegylatedliposo2maldoxorubicin(TLC2D99),paclitaxel,andtrastuzumabinHER222overexpressingbreastcancer:amulticenter[J].ClinCancerRes,2009,15(1):3072314.[10]DestitoG,SchneemannA,ManchesterM.Biomedicalnanotechnolo2gyusingvirus2basednanoparticles[J].CurrTopMicrobiolImmunol,2009,327:952122.[11]PastorinG,WuW,WieckowskiS,etal.Doublefunctionlisati2onofcarbonnanotubesformultimodaldrugdelivery[J].ChemCommun,2006,21(11):118221184.[12]FangC,ShiB,PeiYY,etal.Invivotumortargetingoftumornecrosisfactor2alpha2loadedstealthnanoparticles:effectofMe2PEGmolecularweightandparticlesize[J].EurJPharmSci,2006,27(1):27236.[13]ShengY,LiuC,YuanY,etal.Long2circulatingpolymericnan2oparticlesbearingacombinatorialcoatingofPEGandwater2sol2ublechitosan[J].Biomaterials,2009,30(12):234022348.[14]GeY,ZhangY,XiaJ,etal.Effectofsurfacechargeandag2glomeratedegreeofmagneticironoxidenanoparticlesonKBcel2lularuptakeinvitro[J].ColloidsSurfBBiointerfaces,2009,73(2):2942301.[15]MasamuneA,KikutaK,WatanabeT,etal.Hypoxiastimu2latespancreaticstellatecellstoinducefibrosisandangiogenesisinpancreaticcancer[J].AmJPhysiolGastrointestLiverPhysi2ol,2008,295(4):7092717.[16],.[J].,2009,30(1):17219.[17]SabaNF,WangX,TighiouartM,etal.Examiningexpressionoffolatereceptorsinsquamouscellcarcinomaoftheheadandneck(SCCHN)asatargetforanewnanotherapeuticdrugs[J].ProcAmAssocCancerRes,2009,31(4):4752481.[18],,,.[J].,2007,14(9):6922694.[19],,,.ABCG4[J].,2009,16(1):31235.[20]WongHL,BendayanR,RauthAM,etal.Amechanisticstudyofenhanceddoxorubicinuptakeandrete