泛素调节的蛋白质降解-2004年诺贝尔化学奖简介

2004李炎武谭卫兵邝雪英张伟(510925)2004年诺贝尔化学奖颁给了3位发现细胞是如何摧毁蛋白质的科学家阿龙切哈诺沃阿夫拉姆赫什科和欧文罗斯本文详细介绍了他们的发现,重点介绍了泛素调节下蛋白质降解所需要的各种物质及其机理诺贝尔化学奖泛素调节蛋白质降解2004106,2004,()[1]19471981,1937,,,1969,78,1952,,[2]207080,,,,19791210,,1,,,5,,:,,;,1977Goldberg,,ATP[1],1.11.1.1(ubiquitin),76,8.45ku,1975,1[1],(ubique,everywhere)[1][3],1.1.2E1E2E33,(u-biquitin-activatingenzyme,E1)(ubiquitin-conjugatingenzyme,E2)(ubiquitin-proteinligatingenzyme,E3)3E1,E2E2E2,E3E3E2E3,E2,(5)[3],620041111.1.3(proteasome),30000,1979Goldberg:20S26S,26S20S19S,[4]26S(2)[1],(20S),7~9,(lock)(19S),[5],,(ATP),,E32(,)1.23[1](1)E1,ATP(2)E2,E2(3)E3E2E3,E2()(4)E33(5),(6)7~92,,,,,,,DNA,,[6],,,(FDA)(32)7200411,,,,,,,,,,,,,,,,,,,,,,,,()(),,,,,,,,,:,,,,,,,,,[1]StructuringLearningAroundPrimaryConcepts:TheQuestforEssence.VirginiaRichardson,1997[2][]RonaldBreslowR,..:,1998[3]..:,1986[4],..:,2001(7)[1][2][3].-.,2004,(1):28-31[4]..,1998,(3):235-238[5],.-.,2002,(1):31-34[6].-.,2003,(2):97-100Ubiquitin-mediatedProteinDegradationTheIntroductionoftheNobelPrizeinChemistry2004LIYanwuTANWeibingKUANGXueyingZHANGWei(SchoolofConghua,GuangzhouMedicalCollege,Guangzhou,510925)AbstractTheNobelPrizeinChemistry2004wasawardedtothreescientists:AaronCiechanover,AvramHershkoandIrwinRose.Theysucceededinshowinghowproteinsaredestroyedincells.Thear-ticleintroducetheirdiscovery,especiallythesubstanceswantedinthecourseoftheubiquitin-mediatedproteindegradationandthemechanism.KeywordstheNobelPrize,ubiquitin-mediate,proteindegradation32200411