您好,欢迎访问三七文档
当前位置:首页 > 行业资料 > 其它行业文档 > 骨组织工程多孔支架材料性质及制备技术
:(19742),,,RP(,201800),,,,FabricationandcharacterizationoftheporousscaffoldsforbonetissueengineeringWuJingmeiWuRuofeng(DepartmentofPolymerMaterials,SchoolofMaterialScienceandEngineering,ShanghaiUniversity,Shanghai201800)AbstractTheselectionandfabricationofthedegradationporousscaffoldsisthemainfactorsintheapplicationofthetissueengineeringtechnique.Thepapersummarizedthestudyofthetissueengineeringandthebiodegradationscaffoldsfromthematerialsrequirement,thefavoriteusedmaterialsandthefabricationofthescaffoldandpreviewedtheprospectofthisstudy.Keywordstissueengineering,porousscaffolds,biodegradation,fabrication,[13],,,,[46],,,,,,,1[7,8]:(1):,,,,,(2):,(3):,,90%,,,(4):,,,,32920049NEWCHEMICALMATERIALSVol132No1917©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(5):,,,2,:;,(extracellularmatrix,ECM)ECM,,,,[9],(BG)(HA)(TCP)HATCP(CPC),,HAYoshikawa[10]CPC2BMSC:(1),;(2),,,,,;(3),(PLA)(PGA)(polyphophazenes)(POE)/(pluronic)PLAPGAPLG,,5050[11]PGAPLA:(1),;(2):PLAPGA,8%[12,13]pH[14];(3);(4):[15],,,,HAPLAPGA[16]PLAPGA,HA,[17][18]PLAPLA,-,,[19]HA[20],3,[21],,,,,[22]3.1PGAPGAPLGA,,;,,MikosPGAPLLA,,PGAPLLA,PLLA,PGAPLLAPGAPGA,PGAPLLA,81%500m[23]PLLAPLGA,8132©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(PLLAPLGA)CH3ClCH2Cl2,,/2,,70%,,[24,25],,,2mm/PLLAPLGA,,,/,,Shatri[26]/,PLLAPGA87%,100m/,,,,-,,3.3,,;[27]PLGA,PLGA,PLGA,PLGA/PLGA3.4,[28]:PGAPLLAPLGACO2(515MPa)3,,93%,100m,,,Nam[29]CH2Cl2CHCl3,,,,90%,200500m,3.5/,/-[3032]PLGA,,/,-55,95%,(1335m)/919:©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[1]NeremRM.[J].AnmBiomedEng,1991,19529[2]NeremRM,TissueEngineeringintheUSA,MED.BiolEngComput,1992,3081[3]LangerR1[J].Science,1993,26(5110)920[4]CimaLG1[J].JBiomechEng,1991,113143[5]MatsudaT,DevelopmentofHybridCompliantGraft:RapidPreparationMethodforReconstructionofAvasculaWall.ASA10Trans,1989,25553[6]MowVC1[J].JBiomechEng,1991,113198[7]FreedCE,etal1J.BiodegradablePolymerScaffoldsforTissueEngineeringN.Y.1994,12(7)689693[8]KimBS,etal1[J].TrendBiotechnol,1998,16(5)224231[9].,2000,23(1)1117[10]YoshikawaT,SuwaY,OhigashiH,etal.[J].BiomedMaterEng,1996,6(5)345351[11]AgrawalCM,AthanasiouKA.[J].BiomedMaterRes,1997,35(2)105114[12],,1[J].,1999,37(7)395397[13]BoydeA,CorsiA,QuartoR,etal.Osteoconductioninlargemacroporoushydroxyapatiteceramicimplants:Evidenceforacomplementaryintegrationanddesentegrationmechaniam.Bone,1999,24579589[14]Kirder2HeadCA,GerhartTN,ArmstrongR,etal.Healingboneusingrecombinanthumanbonemorphogeneticproteiv2andcopolymer.ClinOrthop,1998,349205217[15]SittingerM,ReitzedD,DevnerM,etal.[J].JBiomedMasterRes,1996,335762[16]AgrawalE,AchanasionKA.[J].JBiomedMaterRes,1997,38(2)105114[17]SimsCD,ButlerPE,CaoYL,etal.[J]1PlastReconstrSwry,1998,10(6)15801585[18]./.[19].[J].,1999,35(6)[20]HirotaK,NishiharaK,TanakaH1[J].BiomedMaterEngin,1993,33147[21]LiY,MaT,etal.[J].Biomaterials,2001,22609618[22],,.[M].,:,2000.4898[23]MoonyDJ,etal.[J].Biomaterials,1996,17115124[24]IshaugSL,etal.[J].BiomedMaterRes,1997,361728[25]Ishaug2RileySL,etal.[J].Biomaterials,1998,14051412[26]ShastriVP,MartinI,LangerR.MacroporusPolymerFoamsbyHydrocarbonTemplating[M].ProceedingsoftheNationalA2cademyofScience,USA.2000,9719701975[27],,.[J].,2000,48995[28]MooneyDJ.etal.[J].Biomaterials,1996,1714171422[29]NamYS.[J].JBiomedMaterRes,2000,5317[30]NamYS.ParkTG.[J].JBiomedMaterRes,1999,47817[31]SchugensC,etal.[J].JBiomedMaterRes,1996,30449461[32]NamYS,ParkTG.[J].Biomaterials,1999,2017831790:20042062020232©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.
本文标题:骨组织工程多孔支架材料性质及制备技术
链接地址:https://www.777doc.com/doc-4598687 .html