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1007-8738201305-0556-041221*171006827100692012-12-012012-12-21“”2009ZX10004-2022007ZKC-06-021975-Tel029-85251331E-mailhaixiang0924@126.com*CorrespondingauthorE-mailhjj6562@163.com。、。R392.11R373.1+3S852.65+7A。“cytokinestorm”、、1-250%~80%2-5。、。1、Mr、、。、、、、。。、、、。“”。2H5N1。2TNF-α、IL-1、IL-6、IL-12、IFN-α、IFN-β、IFN-γ、MCP-1IL-8。。Ferrara1993“”2005H5N1。3“”。11997H5N1/9722004H5N1/041H1N1RT-PCRELISAH5N1H1N110。6。H1N1H3N2。2009H1N1120037。2。multipleorgansfailureMOFdisseminatedintravascularcoagulopathyDIC8。Akiyama91H1N1。vonWillebrandfactorvWF。vWF。4655ChinJCellMolImmunol2013295、、、、CD8+T。。4.1。H5N1H5N14。Teijaro10S1P1。。S1P1。1918-1919、。。H5N1NF-κB。NF-κBH5N1NF-κBIFN-β11。p50NF-κB12。4.2pDCplasmacytoiddendriticcellspDC。pDC1interferonIFN13。pDCIFN-αIFN-α。Npro3IRF31IFN14。4.315/。Phung16H1N1PR-81nonstructuralprotein1NS1A549TNF-αTregulateduponactivationnormalT-cellexpressedandsecretedRANTESIL-6、IL-8、MCP-1NS1myeloperox-idseMPOIL-8MCP-1。NS1A17NS1MPO。4.4。TNF-α。TNF-αMOFDIC。4.5CD8+T、/18。A/H5N1TNF-α、IFN-γ、IFN-α/β、IL-6、IL-1、MIP-1、MIG、IP-10、MCP-1、RANTESIL-8。CD8+TTNF-αIL-6IFN-γ。1NS1、2polymemsebasicprotein2、hemagglutininHAneuraminidaseNA、、2。NLRP3ARNAcaspase-1IL-1bIL-18。19-20。IL-15A/FM/1/47IL-15CD8+TA21。4.6“--”、322、。TNF-α、IL-6、IL-1β、。。PAR-2ATP-1。。4.7。。。“”。23。5、7555.24。5.1、、。。25。-1-sphingosine-1-phosphateS1P。S1PT126。S1P27。。5.2NAM2H5N1。A/H5、A/H7、A/H9A/H5N150%。。H5N1oseltamivirzanamivirM228-29。oseltamivir5。5.3PPAR-γ。peroxisomeproliferator-activatedrecep-torsPPARNF-κB、AP1STAT。30。5.4SlitIL-1βTNF-α、、、、。London31SlitRobo4。、、H5N1。。5.5H5N1。Jin322PB2H5N1。MDCK、RNARNA。celecoxibPB2PB2celecoxib。5.6。。Zhang23CR2CD59Crry。CR2-CD59CR2-Crry。CR2PBSCR2。CR2。5.7BdirecthemoperfusionwithpolymyxinB-immobilizedfiberPMX-DHPsys-temicinflammatoryresponsesyndromeSIRS33。Bultraviolet-BUVBDH1N134。BordetellapertussisBPZE135。H5N129。2009pH1N1A36。。6。、。。1WalshKBTeijaroJRRosenHetal.Quellingthestormutiliza-tionofsphingosine-1-phosphatereceptorsignalingtoameliorateinflu-enzavirus-inducedcytokinestormJ.ImmunolRes201151855ChinJCellMolImmunol2013295115-25.2UsD.CytokinestorminavianinfluenzaJ.MikrobiyolBul2008422365-380.3WangSLeTQKuriharaNetal.Influenzavirus-cytokine-prote-asecycleinthepathogenesisofvascularhyperpermeabilityinsevereinfluenzaJ.JInfectDis20102027991-1001.4Bouscambert-DuchampMLinaBMorfinF.AvianinfluenzainchildrenJ.ArchPediatr200916Suppl2S101-S107.5ZhengBJChanKWLinYPetal.Delayedantiviralplusimmuno-modulatortreatmentstillreducesmortalityinmiceinfectedbyhighinoculumofinfluenzaA/H5N1virusJ.ProcNatlAcadSciUSA2008105238091-8096.6.J.201228112-16.7ChengXWLuJWuCLetal.Threefatalcasesofpandemic2009influenzaAvirusinfectioninShenzhenareassociatedwithcytokinestormJ.RespirPhysiolNeurobiol20111751185-187.8MizuguchiMYamanouchiHIchiyamaTetal.Acuteencephalopa-thyassociatedwithinfluenzaandotherviralinfectionsJ.ActaNeurolScandSuppl200718645-56.9AkiyamaRKomoriIHiramotoRetal.H1N1influenzaswineflu-associatedthromboticmicroangiopathywithamarkedlyhighplasmaratioofvonWillebrandfactortoADAMTS13J.InternMed2011506643-647.10TeijaroJRWalshKBCahalanSetal.EndothelialcellsarecentralorchestratorsofcytokineamplificationduringinfluenzavirusinfectionJ.Cell20111466980-991.11SchmolkeMViemannDRothJetal.EssentialimpactofNF-kappaBsignalingontheH5N1influenzaAvirus-inducedtranscrip-tomeJ.JImmunol200918385180-5189.12DroebnerKReilingSJPlanzO.RoleofhypercytokinemiainNF-kappaBp50-deficientmiceafterH5N1influenzaAvirusinfectionJ.JVirol2008822211461-11466.13BelMOcaa-MacchiMLinigerMetal.EfficientsensingofavianinfluenzavirusesbyporcineplasmacytoiddendriticcellsJ.Viruses201134312-330.14HüsserLRuggliNSummerfieldA.NproofclassicalswinefeverviruspreventstypeIinterferon-mediatedprimingofconventionaldendriticcellsforenhancedinterferon-αresponseJ.JInterferonCytokineRes2012325221-229.15OslundKLBaumgarthN.Influenza-inducedinnateimmunityregulatorsofviralreplicationrespiratorytractpathology&adaptiveimmunityJ.FutureVirol201168951-962.16PhungTTSugamataRUnoKetal.KeyroleofregulateduponactivationnormalT-cellexpressedandsecretednonstructuralprotein1andmyeloperoxidaseincytokinestorminducedbyinfluenzavirusPR-8A/H1N1infectioninA549bronchialepithelialcellsJ.MicrobiolImmunol20115512874-884.17.H1N1NS1J.2011273287-289.18GongDFarleyKWhiteMetal.CriticalroleofserpinB1inregulatinginflammatoryresponsesinpulmonaryinfluenzainfectionJ.JInfectDis20112044592-600.19AllenICScullMAMooreCBetal.TheNLRP3inflammasomemediatesinvivoinnateimmunitytoinfluenzaAvirusthroughrecog-nitionofviralRNAJ.Immunity2009304556-565.20ThomasPGDashPAldridgeJRJretal.TheintracellularsensorNLRP3mediateskeyinnateandhealingresponsestoinfluenzaAvirusviatheregulationofcaspase-1J.Immunity2009304566-575.21NakamuraRMaedaNShibataKetal.Interleukin-15iscriticalinthepathogenesisofinfluenzaavirus-inducedacutelunginjuryJ.JVirol201084115574-5582.22KidoHChidaJYaoMetal.Mechanismsofmulti-organfailureinsevereinfluenzaJ.NihonRinsho20106881565-1573.23ZhangCXuYJiaLetal.AnewtherapeuticstrategyforlungtissueinjuryinducedbyinfluenzawithCR2targetingcomplementinhibitorJ/OA.VirolJ2010730.
本文标题:细胞因子风暴在流行性感冒病毒感染中的作用及防治研究
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