肠黏膜通透性的研究进展

李秋伟1*(),贾建伟2()(1.,300193;2.,300192):Q735:A:10062084(2007)18138402*2005级硕士研究生:肠黏膜通透性是指肠黏膜上皮容易被某些分子物质以简单扩散的方式通过的特性,是反映肠屏障功能的重要指标本文重点从肠黏膜通透性的检测方法及治疗方面对肠黏膜通透性的研究进展作简单的综述,以期为医疗研究提供借鉴:肠黏膜通透性;检测及治疗;进展ResearchProgressofIntestinalPermeabilityLIQiuwei1,JIAJianwei2.(1.TianjinUniversityofTraditionalChineseMedicine,Tianjin300193,China;2.FirstDepartmentofCombinationofTCMwithWesternmedicine,ContagiousHospitalofTianjin,Tianjin300192,China)Abstract:Intestinalpermeabilityreferstothefeaturethatsomemolecularmaterialcaneasilygothroughintestinalepitheliuminsimplediffusion,whichisanimportantindexreflectingintestinalbarrierfunction.Thisarticlemainlydiscussesstudyprogressofntestinalpermeabilityinitsdetectingmethodandtherapyinordertoprovidereferenceformedicalresearch.Keywords:Intestinalpermeability;Detectionandtreatment;Progress,,,,[1],,,,,1,,4:,,,,,,,,,,2,,[27],,,DNA,,[8],3,3.1:342(0.92nm),,182(0.67nm),,,,,,,,,,,,,,[9],,3.2DD,,,,D,D,D,D,DD,DD,,3.3DNADNA[10],,,1384200791318MedicalRecapitulate,September2007,Vol.13,No.18,3.451Cr99mTc,,,,,3.5(polyethyleneglycol,PEG)PEG400PEG600PEG900PEG1000PEG4000,PEG3350PEG400,,,,,,3.6,354u,,,,,44.1:[11],,,[12],,!:,,[13],1∀:[14],[15],4.270%,,,[16],,,4.3,,,:;!;∀;#;∃;%4.4,,[17],,,,,,[18][19],A2,A2,[20],,,,,,,,,:[1]TravisS,MenziesI.Intestinalpermeabilityfunctionalassessmentandsignificance[J].ClinSci,1992,82(8):7176.[2],.SIRSMODS[J].,2000,7(4):180182.[3]SecchiA,OrtanderlJM,SchmidtW,etal.Effectofendotoxemiaonhepaticportalandsinusoidalbloodflowinrats[J].JSurgRes,2000,89(1):2630.[4]BorosM,TakaichiS,HatanakaK.Ischemictimedependentmicrovascularchangesandreperfusioninjuryintheratsmallintestine[J].JSurgRes,1995,59(2):311320.[5]ZieglerS,SmithRJ,O&DwyerST,etal.Increasedintestinalpermeabilityassociatedwithinfectioninburnpatients[J].ArchSurg,1988,123(6):13131319.[6],,,.[J].,2002,15(1):4547.[7]ChakravorttyD,KumarkSN.Modulationofbarrierfunctionofsmallintestinalepithelialcellsbylaminapropriafibroblastsinresponsetolipopolysaccharide:PossibleroleinTNFAininducingbarrierdysfunction[J].MicrobiolImmunol,1999,43(6):527533.[8],.[J].,2000,5(1):5456.[9]BarbozaJuniorMS,SilvaTM,GuerrantRL,etal.Measurementofintestinalpermeabilityusingmannitolandlactuloseinchildrenwithdiarrhealdiseases[J].BrazJMedBiolRes,1999,32(12):14991504.[10]ClausenMR.Colonicfermentationtoshortchainfattyacidisdecreasedinantibioticassociateddiarrhea[J].Gastroenterology,1991,101(6):14971504.[11],,,.[J].,2003,11(1):1417.[12],,,.[J].,2006,28(9):540542.[13],,,.[J].(),2006,37(1):1013.[14],,.[J].,2002,14(11):650653.[15],,,.[J].,2006,5(5):333335.[16],,,.[J].,2002,10(12):13851388.[17],,,.[J].,2006,20(6):404411.[18],,.[J].,2002,8(8):449451.[19],,,.[J].(),2005,36(2):210212.[20],,,.∋((([J].,2006,12(2):125128.:20061219:200708191385200791318MedicalRecapitulate,September2007,Vol.13,No.18