大肠癌的流行病学因素及其危险因素的研究现状-赵生

CHINAFOREIGNMEDICALTREATMENT,,2[1]19992000,45.80/10,44.33/10,39.54/10,13.29/10,2.26/10[2],,35[3],,Whittemore,,[4],[5][6],1%,1%,5%8%,15%20%,70%75%,90%,,,,Quetelet(/2),,4[7](P0.01),,[8],,,2.1,,Cummings[9]1220,,,,2.2(0.7),,,[10]WillettWC[11]2.5Whittemore,[12]:(1),;(2)DNA,DNA;(3),[13][14],-2.3,ACDE[15],,,,,,R735.3+4A1674-0742(2012)02(b)-0187-02:(1959):,(1983):,CHINAFOREIGNMEDICALTREATMENT,,,5%15%[16]1,2,[17],[16],,(16.786.20)%,1.68,,16.78%,,C[18]2[19],,,,1cm0.3%1.3%,1cm2cm3.6%9.5%;2cm6.8%46%[20],,,,,[1]PetoJ.Cancerepidemiologyinthelastcenturyandthenextdecade[J].Nature2001,411:390395.[2]ParkinDM,PisaniP,FerlayJ.Globalcancerstatistics[J].CACan-cerJClin,1999,49(1):3364.[3].[J].(),2004,33(5):375178.[4].[J].,1998,25(3):225228.[5].[J].,2003,18(1):6870.[6].[J].,2005,32(4):193195.[7],,.[J].),1996,25(5):204206.[8],,.Acaseofcontrolstudyofcolorectalcan-cerinBeijing[J].ChineseJournalofEpidemiology(),1992,13(6):321323.[9]CummingsJH,BinghamSA,HeatonKW,etal.Fecalweight,coloncancerrisk,anddietaryintakeofnonstarchpolysaccharides(dietaryfibers)[J].Gastroenterology,1992,103(6):17831789.[10],.[J].1998,5(1):3031.[11]WillettW,StampferM,ColditzG.Relationofmeat,fat,andfiberintaketotheriskofcoloncancerinaprospectivestudyamongwomen[J].NEnglJMed,1990,323(24):16641672.[12]WhittemoreAS,Wu-williamsAH,LeeM,etal.Diet,physicalactiv-ityandcolorectalcanceramongChineseinNorthAmericaandChina[J].JNatlCancerInst,1990,82:915926.[13],.[J].,2000,27(2):154156.[14],,,.[J].,1992,3:716718.[15].[J].,2007,16(5):323326.[16],.[J].,2004,26(1):13.[17],.[J].,2000,2(15):220222.[18],.[J].,2001,23(6):480482.[19],,.[J].,2001,10(7):377.[20].[J].,2007,16(5):323326.