孤儿受体Nur77与肿瘤的关系

20091511Nur77RelationshipbetweenOrphanReceptorNur77andTumorYUXiao-ting,ZHENGYi-hu,ZHENGFei-yun，，（，325000）：Nur77，，、。，Nur77，；Bcl-2Bcl-2，C，。Nur77，Bcl-2Bcl-2。：；Nur77；；：R730.231：A：1671-170X（2009）11-1043-04Nur77（TR3、NGFI-BNR4A1-3）Nur77，3：Nur77、Nurr1Nor-1[1]。Nur77，，、、。Nur77[2]。，Nur77，，Bcl-2，。Nur77，Bcl-2，。1Nur77Nur77DNA（DBD）。Nur77DNA（DBD）NGFI-B（NBRE）DNA。Nur77N(LBD)[3]。Nur77，，，。Katagiri[4]Nur77DNA，，Nur77。Nur77278~283（KRRRNR）308~313（KGRRGR）。，A，Nur77DNA[3]。，Nur77(LBD)（AA408-417、AA467-476、AA520-530），Nur77，，[4]。Nur77，Nur77。Nur77，、、、、、、、、：：2009-05-07；：2009-09-29104320091511JournalofOncology,2009,Vol.15,No.11。（GR）、（RARγ），Nur77，[5]。2Nur77Nur77，、[6~8]。Kolluri[9]Nur77。，Nur77；，H460Calu-6，Nur77；，RNANur77H460，（EGF）。Nur77。，，Nur77，Nur77[7]。BXNur77，[10]。，Nur77，-1α，-1α、、[11]。Nur77。，Nur77[12]，Nur77X(RXR)[13]COUP-TF[12]。3Nur771994Nur77T，，Nur77[14]。Nur77AHPN（CD437、6-3--4-2-）[15]。Nur77RNANur77，Nur77AHPN。D，Nur77，Nur77[16]。Nur77Nor-1，，Nur77[17]。MCT-15-，Nur77，Nur77[18，19]。，Nur77，、、[20]。，Nur77，：、（Vp-16）、（TPA）[2，21，22]、[6]、[23]、[24]、1，1(3′-)-1-()[25]。Nur77。4Nur77，Nur77Bcl-2，[26]。Nur77，。B(Csn-B)Nur77[27]。N-、，[28，29]。，Nur77[30]。，Nur77。Nur77，：Bcl-2Nur77(LBD)，Nur77[22]，，Nur77Bcl-2Nur77Bcl-2，Nur77，Bcl-2，，104420091511C。，Bcl-2Bcl-2[31，32]，，。Bcl-2。Nur77Bcl-2，Bcl-2，BH3[22]，Bcl-2。Nur77，AHPN/CD437、TPA、Vp-16、1，1(3′-)-1-()、Apoptin，，K2[33]、[34]、B(Csn-B)[27]、Nur779[35]。，6Bcl-2，Nur77Bcl-B，Bcl-B、Bcl-2Bfl-1，，，Bcl-XL、Mcl-1Bcl-W[36]。5，，Nur77。，。Nur77Bcl-2，Bcl-2，。，Nur77Bcl-2，，Nur77-Bcl-2，，，Bcl-2。，Nur77。，Nur77，、。Apoptin，[37]。，Nur77。：[1]MaruyamaK,TsukadaT,OhkuraN,etal.TheNGFI-Bsubfamilyofthenuclearreceptorsuperfamily(review)[J].IntJOncol,1998,12(6):1237-1243.[2]LiH,KolluriSK,GuJ,etal.CytochromecreleaseandapoptosisinducedbymitochondrialtargetingofnuclearorphanreceptorTR3[J].Science,2000,289(5482):1159-1164.[3]MeinkeG,SiglerPB.DNA-bindingmechanismofthemonomericorphannuclearreceptorNGFI-B[J].NatStructBiol,1999,6(5):471-477.[4]KatagiriY,TakedaK,YuZX,etal.ModulationofretinoidsignallingthroughNGF-inducednuclearexportofNGFI-B[J].NatCellBiol,2000,2(7):435-440.[5]CrawfordPA,SadovskyY,WoodsonK,etal.Adrenocorti-calfunctionandregulationofthesteroid21-hydroxylasegeneinNGFI-B-deficientmice[J].MolCellBiol,1995,15(8):4331-4316.[6]JeongJH,ParkJS,MoonB,etal.OrphannuclearreceptorNur77translocatestomitochondriaintheearlyphaseofapoptosisinducedbysyntheticchenodeoxycholicacidderivativesinhumanstomachcancercelllineSNU-1[J].AnnNYAcadSci,2003,1010:171-177.[7]UemuraH,ChangC.AntisenseTR3orphanreceptorcanincreaseprostatecancercellviabilitywithetoposidetreat-ment[J].Endocrinology,1998,139(5):2329-2334.[8]HollaVR,MannJR,ShiQ,etal.ProstaglandinE2regu-latesthenuclearreceptorNR4A2incolorectalcancer[J].JBiolChem,2006,281(5):2676-2682.[9]KolluriSK,Bruey-SedanoN,CaoX,etal.Mitogenicef-fectoforphanreceptorTR3anditsregulationbyMEKK1inlungcancercells[J].MolCellBiol,2003,23(23):8651-8667.[10]LeeMO,KangHJ,ChoH,etal.HepatitisBvirusXpro-teininducedexpressionoftheNur77gene[J].BiochemBiophysResCommun,2001,288(5):1162-1168.[11]YooYG,YeoMG,KimDK,etal.Novelfunctionofor-phannuclearreceptorNur77instabilizinghypoxia-in-duciblefactor-1alpha[J].JBiolChem,2004,279(51):53365-53373.[12]WuQ,LiY,LiuR,etal.Modulationofretinoicacidsen-sitivityinlungcancercellsthroughdynamicbalanceoforphanreceptorsnur77andCOUP-TFandtheirhet-104520091511JournalofOncology,2009,Vol.15,No.11erodimerization[J].EMBOJ,1997,16(7):1656-1669.[13]WuQ,DawsonMI,ZhengY,etal.Inhibitionoftrans-retinoicacid-resistanthumanbreastcancercellgrowthbyretinoidXreceptor-selectiveretinoids[J].MolCellBiol,1997,17(11):6598-6608.[14]LiuZG,SmithSW,MclaughlinKA,etal.Apoptoticsig-nalsdeliveredthroughtheT-cellreceptorofaT-cellhy-bridrequiretheimmediate-earlygenenur77[J].Nature,1994,367(6460):281-284.[15]LiY,LinB,AgadirA,etal.MoleculardeterminantsofAHPN(CD437)-inducedgrowtharrestandapoptosisinhumanlungcancercelllines[J].MolCellBiol,1998,18(8):4719-4731.[16]JiangMM,DaiY,GaoH,etal.CardenolidesfromAntiaristoxicariaaspotentselectiveNur77modulators[J].ChemPharmBull(Tokyo),2008,56(7):1005-1008.[17]MullicanSE,ZhangS,KonoplevaM,etal.AbrogationofnuclearreceptorsNr4a3andNr4a1leadstodevelopmentofacutemyeloidleukemia[J].NatMed,2007,13(6):730-735.[18]LiuHB,VosoMT,GumieroD,etal.Theanti-leukemicef-fectofanovelhistonedeacetylaseinhibitorMCT-1and5-aza-cytidineinvolvesaugmentationofNur77andinhibi-tionofMMP-9expression[J].IntJOncol,2009,34(2):573-579.[19]HamidT,MalikMT,MillarRP,etal.ProteinkinaseAservesasaprimarypathwayinactivationofNur77ex-pressionbygonadotropin-releasinghormoneintheLbe-taT2mousepituitarygonadotrophtumorcellline[J].IntJOncol,2008,33(5):1055-1064.[20]RrmaswamyS,RossKN,LanderES,etal.Amolecularsignatureofmetastasisinprimarysolidtumors[J].NatGenet,2003,33(1):49-54.[21]LiuS,WuQ,YeXF,etal.InductionofapoptosisbyTPAandVP-16isthroughtranslocationofTR3[J].WorldJGastroenterol,2002,8(3):446-450.[22]LinB,KolluriSK,LinF,etal.ConversionofBcl-2fromprotectortokillerbyinteractionwithnuclearorphanre-ceptorNur77/TR3[J].Cell,2004,116(4):527-540.[23]GennariA,BleuminkR,VivianiB,etal.Identificationb