γ-亚麻酸的保健作用

:,,17ToftumJ,JorgensenAS,FangerPO.Upperlimitsofairhumidityforpreventingwarmrespiratorydiscomfort.EnergyBuild,1998,(28):15238BerglundLG.Perceivedairqualityandthethermalenvironment.IAQ,1989:93999..:,198910DanielWTChan.AnassessmentofthermalcomfortinofficepremisesinHongKong.ASHRAEtrans,1998,104(1):8011,,..,1999,2:3012RichardJ,deDear,GallSB.DevelopinganAdaptiveModelofThermalComfortandPreference.ASHRAETrans,1998,104(1):9813FangerPO.Predictionofthermalsensationinnon2air2conditionedbuild2ingsinwarmclimates.IndoorAir,2002,15:4814,,,...2001,30(1):626315,,,..,2001,30(6):38338416WangXL.Thermalcomfortandsensationundertransientconditions.Stockholm:TheRoyalInstituteofTecjnology,1994,6717,.,..,2000,2:5618,..,1999,25(2):91319TaoP.TheThermalSensationdifferencebetweenChineseandAmericanPeople.IndoorAir,1991,4:70(2002206230)32320035JOURNALOFHYGIENERESEARCHVol.32No.3May2003299:100028020(2003)032029920321,1100322(GLA),,,22122(2linolenicacid,GLA),C18H30O2,,,;,2,,,,,(linodeicacid,LA)262,2(dihomo22Li2nolenicacid,DGLA),E1(PGE1),25(arachidonicacid,AA)(PGS),26,2,,,2,,[1]22(TC),160,:1)E1(PGE1)TC;2)2,TC,,TC3)(TG),TC,2;4)2(HDL),,(LDL2C),,28115%6812%6418%[13],[4]3A2A2(TXA2),,,TXA2,,2E1,,2(dihomo22linolenicacid,DGLA)TXA2,A2,2[5]4(VSMC)2,,(VSMC)VSMCCAMP2(VSMC)E1(PGE1)(1:501:100)VSMC;2CAMPE1(110nmol)cAMP,,:2E1VSMC,VSMCDNA812%1011%2,E1(PGE1)4,2(GLA)VSMCDNA[6]5Huang[114C](60molPL)[114C]21,[114C],115%,(AA),,222,E2(PGE2)PGE2[7,8],CAMP,,,2,,,,Horrobin[9],26240,[1012],,,26,(1811),Hrelia2[13],2,,,Jiang2,E2,2Cxtenin(E2),2Cxtenin[14]7HIVKinchingtin,2(Li2GLA)4,90%HIV,20%,E,LiGLA,LiGLAHIV[15]LiGLA20gPml,HIVT2,2450%2(TNF2),,Li2GLA,GLA82,2,,,Ohta10(MRSA),GLA,GLA500gPml,15[16],Gianarellox2BourbcalisGLAPseudomonasaeruginosa(MIC=200300mgPml)[17],GLA,,GLA[18]GLA[15],GLA15,6191121152(ODTA)(GLA10)9,GLA[1921]10,GLA,GLACCl,GLACCl4[22]1126,,,,,12Awada,2,()2,,2,2[23],200332132,,,2,,28kg75%[3],,2[2426],,2141,121,1994,29(5):2632672,,,1301,1990,9(1):8103,,,11,1988,8(8):4694714,,,..,1991,26(10):5975985,,,122A1,1987,13(1):156FanYY,RamosKS,ChapkinRS,etal.Dietary2linolenicacidmodu2latesmacrophage2vascularsmoothmusclecellinteractions:evidenceforamacrophage2derivedsolublefactorthatdownregulatesDNAsynthesisinsmoothmusclecells.ArteriosclerThrombVascBiol,1995,15(9):139714037HuangYS,CantrillRC,DeMarcoA,etal.Differencesinthemetabolismof182n26and183n26bytheliverandkidneymayexplaintheanti2hy2pertensiveeffectof183n261BiochemMedicMetabBiol,1994,51(1):27348.14.:,1997,879,,,12Ê®ÌÓ.(),1993,42(4):24225310CantrillRC,EllsGW,ChisholmKA,etal.Variationsintemperatureandoxygencontentdonotalterlevelsofthiobarbituratereactivematerialinhumanbreasttumourcells(ZR27521)incubatedwithgamma2linolenicacid.AnticancerRes,1993,13(5A):1461146411RameshG,DasUN.Effectoffreefattyacidsontwo2stageskincarcino2genesisinmice.CancerLett,1996,100(1,2):19920912AntuenoRDe,ElliotM,EllsG,etal.Invivoandinvitrobiotransfor2mationofthelithumsaltofgamma2linolenicacidbythreehumancarcino2mas.BrJCancer,1997,17(12):1812181813HreliaS,BordoniA,BiagiP,etal.2linolenicacidsupplementationcanaffectcancercellproliferationviamodificationoffattyacidcomposi2tion.BiochemBiophysResCommun,1996,225(2):44144714JiangWG,HiscoxS,HallettMB,etal.RegulationoftheExpressionofE2cadherinonhumancancercellsby2linolenicacid(GLA).CancerRes,1995,55(21):5043504815KinchingtonD,RandallS,WintherM,etal.Lithium2linolenate2in2ducedcytotoxicityagainstcellschronicallyinfectedwithHIV21.FEBSLeet,1993,330(2):21922116OhtaS,ChangT,KawashimaA,etal.Antibioticactivityofunsaturatedfattyacidsonmethicillin2resistantstaphylococcusaureus.BiosciBiotechBiochem,1993,57(12):2194219517Giamarellos2BourboulisEJ,GreckaP,Dionyssiou2AsteriouA,etal.InvitroinfluenceofpolyunsaturatedfattyacidsonnosocomialPseudomonasaeruginosa:apreliminaryreport.InteAntimicrobAgents,1995,6(1):475018Giamarellos2BourboulisEJ,GreckaP,Dionyssiou2AsteriouA,etal.Invitroinhibitoryactivityofgamma2linolenicacidonEscherichiacolistrainsanditsinfluenceontheirsusceptibilitiestovariousantimicrobialagents.JAntimicrobChmother,1995,36(2):32733419,,,11,1986,17(6):394020ZurierRB,RossettiRG,JacobsonEW,etal.Gamma2linolenicacidtreatmentofrheumatoidarthritis:arandomized,placebo2controlledtrial.ArthritisRheum,1996,39(11):1808181721JohnsonMM,SwanDD,SuretteME,etal,Dietarysupplementationwith2linolenicacidaltersfattyacidcontentandeicosanoidproductioninhealthyhumans.JNutr,1997,127(8):143514442211,1998,6(4):384023AwadaAB,ZeppEA.Alterationofratadiposetissuelipolyticresponsetonorepinephrinebydietaryfattyacidmanipulation.BiochemBiophysResCommun,1979,86(1):13814424LovellCR,BurtonJL,HorrobinDF.Treatmentofatopiceczemawitheveningprimroseoil.Lancet,1981,1(8214):27825JamalGA,CarmichaelH,WeirIW.Gamma2linolenicacidindiabe2tieeneuropathy,Lancet,1986,1(8489):109826P.M.S.OBrienThepremenstrualsyndrome:areviewofthepresentstalusoftherapy.Drugs,1982,24(2):140151(2002209225)1033,.2