Omega-3多价不饱和脂肪酸与冠心病

[e-mail]··Omega_3Omega_3PUFAＲ541.4A1009_816X201603_0224_03doi10.3969/j.issn.1009_816x.2016.03.2012Omega_3PUFACVD。EPADHA34。O-mega_3PUFACVD5。6。Omega_3PUFA。1Omega_3PUFA302CADOmega_3PUFA。78Omega_3PUFA、。Harris925MCVOmega_3PUFADHA。。DAＲT1020333123。13%～4%229%。32。450mgEPAeicosapen-taenoicacedDHAdocosahexaenoicacidCVD56%62%。2～3/。Daviglus1182240～55CVD0g1～17g18～34g≥35g。35gCVD。＜1/Hu1112CVD。Omega_3PUFATheGISSI13。11323Omega_3PUFA850mg/EPADHA=12、E300mg/、Omega_3FUFAVitE3.5Omega_3PUFAOmega_3PUFAE、21%30%。Omega_3PUFA4115%。JELIS4EPA。18645=37EPA1800mg/。5EPA·422·PreventionandTreatmentofCardio_Cerebral_VascularDiseaseJun2016.Vol16.No319%。EPA。Omega_3PUFA。O-mega_3PUFA。。OMEGA1438511Ome-ga_3PUFA1000mg/EPADHA=1.21Omega_3PUFA。、Omega_3PUFA。、。2Omega_3PUFACHDOmega_3PUFA1TGTG、TGTG15。2。、16。3EPATXA2PGI3。3Omega_3PUFAOmega_3PUFA2、、eicosapentaenoicacedEPAdocosahexaenoicacidDHA1g。EPA+DHAI_BIIa_CTGOmega_34g/dI_ATG。Omega_3PUFA。Omega_3PUFAOmega_3PUFA。Omega_3PUFATG。41。Omega_3PUFA。Omega_3PUFAOmega_3PUFAVcEDFVdEDF17。Omega_3PUFANF_kBCOX_2181920。2。Itariu21Kiecolt_Glaser22Omega_3PUFA。3Naoko2324。。Omega_3PUFA。Lavie24JACC。1DaviglusMLStamlerJOrenciaAJetal．Fishconsumptionandthe30_yearriskoffatalmyocardialinfarctionJ．NEnglJMed1997336151046－1053．2HarrisWSPostonWCHaddockCK．Tissuen_3andn_6fattyacidsandriskforcoronaryheartdiseaseeventsJ．Atherosclerosis200719311－10．3ＲheeYPaikMJKimKＲetal．PlasmafreefattyacidlevelpatternsaccordingtocardiovascularriskstatusinpostmenopausalwomenJ．ClinChimActa20083921－211－6．4YokoyamaMOrigasaHMatsuzakiMetal．Effectsofeicosapentae-noicacidonmajorcoronaryeventsinhypercholesterolaemicpatientsJELISarandomisedopen_labelblindedendpointanalysisJ．Lancet200736995671090－1098．5Kris_EthertonPMHarrisWSAppelLJ．Fishconsumptionfishoilomega_3fattyacidsandcardiovasculardiseaseJ．Circulation2002106212747－2757．6．M．1．19935－6．231·522·《》201661631．J．20123218－11．2．J．20097121358－1360．3．2010J．2011198701－743．4．J．2014182108－111．5．MoriskyJ．201018111067－1069．6．J．201233247－8．7．J．2012103241－243．8．－J．201420183397－3399．2016_2_26櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵櫵2257KromhoutDBosschieterEBdeLezenneCoulanderC．Theinverserelationbetweenfishconsumptionand20_yearmortalityfromcoronaryheartdiseaseJ．NEnglJMed1985312191205－1209．8AlbertCMHennekensCHO’DonnellCJetal．FishconsumptionandriskofsuddencardiacdeathJ．JAMA1998279123－28．9HarrisWSPostonWCHaddockCK．Tissuen_3andn_6fattyacidsandriskforcoronaryheartdiseaseeventsJ．Atherosclerosis2007193121－10．10BurrMLFihilyAMGilbertJFetal．EffectsofchangesofinfatfishandfibreintakesondeathandmyocardialreinfarctionDIATANDＲEINFAＲCTIONTＲIALDAＲTJ．Lancet198928666757－761．11HuFBBronnerLWillettWCetal．Fishandomega_3fattyacidintakeandriskofcoronaryheartdiseaseinwomenJ．JAMA2002287141815－1821．12HuFBChoEＲexrodeKMetal．Fishandlong_chainomega_3fattyacidintakeandriskofcoronaryheartdiseaseandtotalmortalityindiabeticwomenJ．Circulation2003107141852－1857．13InvestigatorsG_P．Dietarysupplementationwithu_3polyunsaturatedfattyacidsandvitaminEaftermyocardialinfarctionresultsoftheGIS-SIPrevensiontrial．GruppoItalianoperloStudiodellaSopravvivenzanell’InfariomiocardicoJ．Lancet19993549177447－455．14ＲauchBSchieleＲSchneiderSetal．OMEGAarandomizedPlacebocontrolledtria1totesteffectofhighpurifiedomega_3fattyacidsontopofmodernguideline_adjustedtherapyaftermyocardialin-farctionJ．Circulation20101222152－2159．15HarrisWSMillerMTigheAPeta1．Omega_3fattyacidsandcor-onaryheartdiseaseriskclinicalandmechanisticperspectivesJ．Atherosclerosis2008197112－24．16SaravananPDavidsonNCSchmidtEBetal．Cardiovasculareffectsofmarineomega_3fattyacidsJ．Lancet20103768540－550．17MatsumotoTNakayamaNIshidaKetal．Eicosapentaenoicacidimprovesimbalancebetweenvasodilatorandvasoconstrictoractionsofendothelium_derivedfactorsinmesentericarteriesfromratsatchronicstageoftype2diabetesJ．PharmacolExpTher20093291324－334．18ChenHLiDChenJetal．EPAandDHAattenuateox_LDLin-ducedexpressionofadhesionmoleculesinhumancoronaryarteryendo-thelialcellsviaproteinkinaseBpathwayJ．MolCellCardiol2003357769－775．19CasosKSaizMPＲuiz_SanzJIetal．Atherosclerosispreventionbyafishoil_richdietinapoE－/－miceisassociatedwithare-ductionofendothelialadhesionmoleculesJ．Atherosclerosis20082012306－317．20MasEWoodmanＲJBurkeVetal．Theomega_3fattyacidsEPAandDHAdecreaseplasmaF2_isoprostanesＲesultsfromtwoplace-bo_controlledinterventionsJ．FreeＲadicＲes2010449983－990．21ItariuBZeydaZHochbruggerEetal．Longchainn_3PUFAsre-duceadiposetissueandsystemicinflammationinseverelyobesenondi-abeticpatientsarandomizedcontrolledtrialJ．AmJClinNutr2012961137－1149．22Kiecolt_GlaserJBeluryMAndridgeＲetal．Omega_3supple-mentationlowersinflammationinhealthymiddle_agedandoldera-dultsarandomizedcontrolledtrialJ．BrainBehavImmun2012266988－995．23MiyagawaNMiuraKOkudaNetal．Long_chainn_3polunsat-uratedfattyacidsintakeandcardiovasculardiseasemortalityriskinJapaneseA24_yearfollow_upofNIPPONDATA80J．Atheroscle-rosis2014232384－389．24LavieCJMilaniＲVMehraMＲVenturaHO．Omega_3polyunsat-uratedfattyacidsandcardiovasculardiseasesJ．JAmCollCardiol2009547585－594．2015_12_4·132·《》20166163