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2006-3-31BioinformaticsdatabaseBioinformaticsdatabase2006-3-31••••2006-3-31..••NucleicAcidsResearch•20001128115•200685820051392006-3-31••GenBank•Embl•DDBJ•SWISS-PROT•NCBI••SCOPStructuralclassificationofproteinsMRC•OMIM••CGAPTheCancerGenomeAnatomyProject://://•BLAST•PRIMER•EMBL2006-3-31•••••••2006-3-31•••biochemie.web.med.uni-muenchen.de/yeast_biology2006-3-31••LIMBLIMB://molbio.info.nih.gov/molbio/db.html••••Entrez••SRS(SequenceRetrievalSystem)•100782006-3-311.Entrez1.EntrezNCBINCBI••19911991NationalCenterforBiotechnologyNationalCenterforBiotechnologyInformation,NCBIInformation,NCBI••GenBank,EMBL•Swiss-port,PIR,PRF,PDB•MMDB•PubMed2006-3-31Entrez2006-3-31EntrezEntrez2006-3-31PDGFPDGF2006-3-3120062006••19991999--20062006PDGFPDGF••••PDGFhumantumor[PDGFhumantumor[titi]]••Publicationyear:1999Publicationyear:1999--200620062006-3-312.BLAST2.BLAST••BasicLocalAlignmentBasicLocalAlignmentSearchToolSearchTool••2006-3-312006-3-31BLASTBLAST••blastpblastp••blastnblastn••blastxblastx••tblastntblastn••tblastxtblastx2006-3-313.NCBIstructure3.NCBIstructure(3D)(3D)::••(MMDB),(MMDB),;;••(CDD),(CDD),proteins(CDs)proteins(CDs),,2006-3-31MMDBMMDB••••1doi1doi••ferredoxinsferredoxins2006-3-314.OMIM4.OMIM••OnlineOnlineMendelianMendelianInheritanceinManInheritanceinMan••JohnsHopkinsJohnsHopkinsNCBINCBI2006-3-312006-3-315.NCBI5.NCBIGENOMEGENOME•NCBI•GenomeEntrezMapViewer2006-3-31••FMR1FMR1cDNAcDNA,,33’’55’’2006-3-31••plasmodiumplasmodiumfalciparumfalciparum2006-3-31mousePaimousePai--1155‘‘GenomeGenomeMepMepViewerViewer55‘‘,,BlastGenomeBlastGenome2006-3-31••OMIMOMIMKeratoderma,palmoplantarKeratoderma,palmoplantar2006-3-316.6.•PCRDNA12023G+C40%~60%PCR•Web2006-3-31••PrimerPrimerPremierPremier5.05.0••primer3primer3WHITEHEADINSTITUTEWHITEHEADINSTITUTE://frodo.wi.mit.edu/cgi--bin/primer3/primer3_••••••2006-3-31••••2006-3-31••••XXNMRNMR••2006-3-311.1.2.2.3.3.4.4.5.5.2006-3-317.1.7.1.7.1.17.1.1ExPASyExPASy://://://://~nomi/nnpredict.ht~nomi/nnpredict.htmlml7.3.27.3.2PredictProteinPredictProtein://://••PHDPHD--PredictProteinPredictProtein::••::••Secondarystructure)Secondarystructure)••Residuesolventaccessibility)Residuesolventaccessibility)••LocationofLocationoftransmembranetransmembranehelices)helices)••Foldrecognition)Foldrecognition)••predictionofpredictionoftopologyforhelicaltopologyforhelicaltransmembranetransmembraneproteins)proteins)••evaluationofpredictionevaluationofpredictionaccuracy)accuracy)2006-3-31PredictProteinPredictProtein11SWISSSWISS--PROTPROTMaxHomMaxHommultiplesequencealignment)multiplesequencealignment)PHDPHDneuralnetworkpredictions)neuralnetworkpredictions)2006-3-31••PHDPHD••PHDsecPHDsec::secondarysecondarystructruestructrueprediction)prediction)helix),helix),strand)strand)••PHDaccPHDacc::solventaccessibility)solventaccessibility)0.5.0.5.••PHDhtmPHDhtm::89%89%86%86%2006-3-3122FoldFoldrecognitionbypredictionrecognitionbyprediction--basedthreading)basedthreading)PDBPDBalignment)alignment)firsthitfirsthit))30%30%zz--scoresscores3.03.060%60%2006-3-3133overallthreeoverallthree--stateaccuracy),stateaccuracy),singestateaccuracy)singestateaccuracy)correlationcorrelationcoefficeentsc
本文标题:87生物信息学数据库
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