孕激素在口服避孕药中应用-王蓓颖

732015Vol.36No.273Enovid60117α-19-17α-200040R977.1+2A1672-9188201502-0073-042014-08-292014-10-29ProgestinusedforsteroidoralcontraceptivesWANGBei-yin,WANGHai-yunDepartmentofFamilyPlanning,ShanghaiFirstMaternityandInfantHospital,TongjiUniversitySchoolofMedicine,Shanghai200040,ChinaAbstract:Thesteroidoralcontraceptivescontributeenormousmeritforfamilyplanning.Itconsistsofsyntheticestrogenandprogestin,suchasethinlyestradiol(EE)anddifferentprogestin.Thisreviewdescribesdifferentoralcontraceptivesforrationalselectiveusage.Keywords:oralcontraceptive;estrogen;progestin;familyplanning117α-17α-25220.035mg1mg19-SHBG2mg0.035mg35PCOS742015Vol.36No.27423PCOSIR219-19-20708042.12060Enovid150g9.85mg105g3551019-10510.035mg0.6mgLoloestrinFe0.01mg1mgFDA2.210SHBG618-0.03mg0.15mgTriquilar0.05mg0.03mg60.075mg0.04mg50.125mg0.03mg1040%Lybrel0.09mg0.02mg3652.3desogestrelHDL-Organon0.15mg0.03mgMercilon0.15mg0.02mg4SHBGMinule0.075mg0.03mg752015Vol.36No.27570.180.2150.25mg0.025mg89310-1112PMS13141215ScheringAGYasmin3mg30mg19-2mg/16HRT172mg30g1995Valette20105NataziaFDA/417A-19-Gestodene762015Vol.36No.2761Chabbert-BuffetN,MeduriG,BouchardP,etal.Selectiveprogesteronereceptormodulatorsandprogesteroneantagonist:mechanismofactionandclinicalapplicationsJ.HumReprodUpdate,2005,113:293-307.2,,.J.,2012,4136:3807-3808,3811.3,,,.J.,2003,3812:28-31.4.3J.,2005,2119-11.5.M.3.:,2003:1186-1187.6BenagianoG,CarraraS,FilippiV.Safety,efficacyandpatientsatisfactionwithcontinuousdailyadministrationoflevonorgestrel/ethinylestradioloralcontraceptivesJ.PatientPreferAdherence,2009,3:131-143.7.J.2008,253:233-2368EndrikatJ,HiteR,BannemerschultR,etal.Multicenter,comparativestudyofcyclecontrol,efficacyandtolerabilityoftwolow-doseoralcontraceptivescontaining20mcgethinylestradiol/100mcglevonorgestreland20mcgethinylestradiol/500mcgnorethisteroneJ.Contraception,2001,641:3-109KemmerdenJM,AlgraA,GrobbeeDE.Thirdgenerationoralcontraceptivesandriskofvenousthrombosis:metaanalysisJ.BrMedJ,2001,3237305:131-13410Sitruk-WareR.PharmocologicalprofileofprogestinsJ.Maturitas,2004,474:277-283.11Sitruk-WareR.Newprogestogens:areviewoftheireffectsinperimenopausalandpostmenopausalwomenJ.DrugsAging,2004,2113:865-883.12,,,.J.,2006,418:572-57613YuzpeAA.Oralcontraception:trendsovertimeJ.JReprodMed,2002,4711Suppl:S967-S973.14RübigA.Drospirenone:anewcardiovascular-activeprogestinwithantialdosteroneandantiandrogenicpropertiesJ.Climacteric,2003,6Suppl3:S49-S54.15OelkersW.Antimineralocorticoidactivityofanoveloralcontracep-tivecontainingdrospirenone,auniqueprogestogenresemblingnaturalprogesteroneJ.EurJContraceptReprodHealthCare,2002,7Suppl3:S19-S26.16WiegratzI,LeeJH,KutscheraE,etal.Effectofdienogest-containingoralcontraceptivesonlipidmetabolismJ.Contraception,2002,653:223-229.17SchneiderHP.TheroleofantiandrogensinhormonereplacementtherapyJ.Climacteric,2000,3Suppl2:S21-S27.1234512