昼夜节律钟基因与精神障碍_孙振晓

··孙振晓于相芬孙波【】R749【】A【】1007-3256201204-0242-05276005、。、、－、。、－。1122424circadianrhythms。entrainment。。、。os-cillator、input、outputintegrationorregulation。。SCN。、SCN。、G。mRNA。SCN。、。SCNPERcryptochromeCRYCLOCK/BMALCLOCKBMAL1ARNT1ARNTLMOP3PERPER1、PER2、PER3CRYCRY1、CRY2E－boxPER、CRY。RorαRev－ErbαBMAL1。NPAS2PAS－2BMAL1。E－boxPER、CRYPERCRY、。IεCKIε、IδCKIδ3GSK3。FBXL3β－TRCP1。PERCRY2422012254、。、－。2－－。TohKL3FASPDPER2PER2CKIδ/ε、。FASPDCKIδ。DSPDPER3。PER3－2。Viola4SWSPER3、。CLOCK－2。12CLOCK3111CCLOCK3111T/T。CLOCK3111C/CCLOCK3111C/CDSPD。5。BPD、。BPDBPD。BSPD6。16%BPD、BSPD7．3%2。。3、3．1MDDMDD。80%～90%。。REMRL、REM。。CBT、2。MDD。DesanPH7143MDDCLOCK3111C。5－GSK35。GSK3、、、、2。3．2BPDBPD。、、RL。－。///。BPD34220122542。BPDCLOCK3111T/C。CLOCKC/C、BPD2。MansourHA8BPD8BMAL1、CLOCK、PER1、2、3、CRY1、2、TIMELESSSNPBMAL1ARNTLTIMELESSBPD。BPDBMAL1ARNTLPER3TIME-LESS2。。SCN。BPDREM。GSK3。GSK3。GSK3mPER2GSK3PER2REV－ERBα。GSK32。GSK3β－50T/CSNPGSK3βT/TBPDGSK3βT/CGSK3βC/C9。3．3SADSADNREMNREM。SAD－2。PartonenT10PERIOD2、NPAS2BMAL1ARNTLSAD189SAD1893SNPBMAL1、PER2NPAS2SAD3SNPSAD4．4310．67。SADNPAS2471PER3647Val/Gly/SAD2。SAD。3．4GADPTSDPTSDREM。2。PER1mRNA11。CLOCK2。3．5、TST、、、SWS。。－、。24。CBT、、2。4422012254。TakaoT2145CLOCKSNPT3111CSCN。D2CLOCKBMAL1。PER1mRNA。PER3TIME-LESS、、BPD8。CRY112q23－q24．1SNPlinkagehotspot12q2413。3．6AlzheimerAD－“”、、、TST、、REMRL、。AD2。ADCBT、、。ADCBTCBT2。AD－SCN2。BMAL1、CRP1、PER1、、、β1mRNA、。ADADSCN14。SCNADCBT－。3．7、、、。、、、、。。。SpanagelR15PER2PER2PASPER－ARNT－SIMEaat1。PER2。acamprosate。PER2。4BPDCLOCKGSK3。SAD。、。。1．J．2003134430～436．2LamontEWLegault－CoutuDCermakianNetal．Theroleofcir-5422012254cadianclockgenesinmentaldisordersJ．DialoguesClinNeuros-ci200793333～342．3TohKLJonesCRHeYetal．AnhPer2phosphorylationsitemu-tationinfamilialadvancedsleepphasesyndromeJ．Science200129155061040～1043．4ViolaAUArcherSNJamesLMetal．PER3polymorphismpre-dictssleepstructureandwakingperformanceJ．CurrBiol2007177613～618．5MansourHAWoodJChowdariKWetal．Circadianphasevaria-tioninbipolardisorderJ．ChronobiolInt2005223571～584．6DaganYBorodkinK．Behavioralandpsychiatriccosequencesofsleep－wakescheduledisordersJ．DialoguesClinNeurosci200574357～365．7DesanPHOrenDAMalisonRetal．GeneticpolymorphismattheCLOCKgenelocusandmajordepressionJ．AmJMedGenet2000963418～421．8MansourHAWoodJLogueTetal．Associationstudyofeightcir-cadiangeneswithbipolarIdisorderschizoaffectivedisorderandschizophreniaJ．GenesBrainBehav200652150～157．9BenedettiFBernasconiALorenziCetal．Asinglenucleotidepolymorphismglycogensynthasekinase3－betapromotergenein-fluencesonsetofillnessinpatientsaffectedbybipolardisorderJ．NeurosciLett20043551～237～40．10PartonenTTreutleinJAlpmanAetal．ThreecircadianclockgenesPer2ArntlandNpas2contributetowinterdepressionJ．AnnMed2007393229～238．11AkiyamaMKirihareTTakahashiSetal．ModulationofmPer1geneexpressionbyanxiolyticdrugsinmousecerebellumJ．BrJPharmacol199912871616～1622．12TakaoTTachikawaHKawanishiYetal．CLOCKgeneT3111CpolymorphismisassociatedwithJapaneseschizophrenicsaprelimi-narystudyJ．EurNeuropsychopharmacol2007174273～276．13PengZWChenXGWeiZ．Cryptochrome1maybeacandidategeneofschizophreniaJ．MedHypotheses2007694849～851．14WuYHFischerDFKalsbeekAetal．Pinealclockgeneoscilla-tionisdisturbedinAlzheimer＇sdiseaseduetofunctionaldiscon-nectionfromthemasterclockJ．FaseebJ200620111874～1876．15SpanagelRPendyalaGAbarcaCetal．TheclockgenePer2in-fluencestheglutamatergicsystemandmodulatesalcoholconsump-tionJ．NatMed200511135～42．2012－04－07《》DVD2/48“”。4560、、、[e-mail]1340005595545210029264。《———》DVD3/95《》DVD3/4590《》DVD12540“”。《》18《》30。《》、《》3712、、、、、。[e-mail]13588480677。6422012254