糖尿病的研究现状及进展

、P＜0.01P＜0.05、P＞0.05②8、、、。181。5DPNDPN19。DPN、、、20。DPN。①DPN②DPN。DPN。1．J．2011922119-121.2．J．20103143-4.3．J．201231351.4．J．2012304702-703.5．J．2008264818-820.6．、J．2009312209-210.7．J．20114331-2.8．J．201017983.9．J．2001288451-452.10．J．200927121040-1041．11．J．20103291293-1295．12．J．20113134-6．13．48J．201125445-50．14．J．2012242126-128．15．J．200825673-74．16．J．2012272378-381．17．J．200711163069-3073.18．J．200725122608-2610．19．J．201247194-96．20．J．201037136-37．2014-09-292014-12-01※543000Ｒ781.64A1006-2084201513-2418-03doi10.3969/j.issn.1006-2084.2015.13.045、、、、、、。、。CurrentSituationandProgressofStudyonDiabetesQIANHongLUＲui-ming．DepartmentofEndo-crinologyWuzhouPeople'sHospitalWuzhou543000ChinaAbstractAtpresentmanystudiesreportedthatdiabetesistheresultofinteractionsofgeneticfactorsautoimmunefactorsandenvironmentalfactorsandtheresearchaboutthetreatmentofdiabetesmellitusmainlyfocusesondiettherapyexercisetherapyanddrugtherapyandnewbreakthroughshavebeenachievedingenetherapyinsulinsensitizingeffectandinsulinthree-dimensionalstructurecomprehensivepreventionandtreatmentofdiabetesandsurgeryandstemcelltherapy．Heresummarizesthereportsaboutdiabetesresearchathomeandabroadinrecentyearsanalyzingthecurrentsituationofdiabetesfromaspectsofpatho-genesisdiagnosisandtreatment．KeywordsDiabetesmellitusPathogenesisDiagnosisTreatment。、、、。1.4、·8142·201572113MedicalＲecapitulateJul．2015Vol．21No．131。、。、。、。。11.131、22。、2。31。2、、。、、、、、4。92296DNAA1A12225。6———7。1.219801198518。11119859。11。2007《2》102005《2》112。21999200312。、1h、2h22。MrtzgerCoustan1314。201124～2875g≥5.1mmol/L1h≥10.0mmol/L、2h≥8.5mmol/L15。1.3、16。1.3.1。、、、、。1.3.2。。。17。1.3.3。①、②、、、③αB、18④、、⑤192、2。、、β。2、。2.120101220。·9142·201572113MedicalＲecapitulateJul．2015Vol．21No．1321fibroblastgrowthfactors21FGF21、、FGF2121-22。201272“”23。224。2013“”“”“”25。2.2。。2011226。227。1694477%28。29。1030。3。、。、、、5、、。1．、、J．2013217661-665.2．2J．20041511-15.3．1Foxp3+TJ．201329176-78.4．2—2J．201333117-18.5．J．2013294299-302.6．B12J．2013335396-397.7OkumusSIgciYZTaskinTetal．Associationbetweenthr21metandser89asnpolymorphismsoftheurotensin-IIUTS2genedia-betesmellitusanddiabeticretinopathyJ．CurrEyeＲes20123710921-929.8．J．19992176-93.9．2J．2011153122-124.10《》．M．2004124-131.11．14J．20092011678-831.12．11J．2013303597-600.13MetzgerBECoustanD．SummaryandrecommendationsofthefourthinternationalworkshopconferenceongestationaldiabetesmellitusJ．DiabetesCare1998212161-167.14爦im爧ekEBinayFlanaganSEetal．Congenitalhyperinsulinismpresentingwithdifferentclinicalbiochemicalandmoleculargenet-icspectraJ．TurkJPediatr2014556584-590.15AmencanDiabetesAssociation．Standardsofmedicalcareindiabe-tes—2011J．DiabetesCare201134Sup14-10.16．-J．201130111-15.17ＲezvanNHosseinzadeh-AttarMJMasoudkabirFetal．SerumvisfatinconcentrationsingestationaldiabetesmellitusandnormalpregnancyJ．ArchGynecolObstet201228551257-1262.18．J．2013434291-297.19．J．2012328858-863.20．J．20122361557-1558.21．J．2012263261-264.22BrownSAGarcAAWinterMetal．IntegratingeducationgroupsupportandcasemanagementfordiabeticHispanicsJ．EthnDis201121120-26.23ZhangJZhangKGaoZGetal．Agonist-boundstructureofthehumanP2Y12receptorJ．Nature20145097498119-122.24．J．2013294241-243.25．J．20115924133-138.26．J．20131918342-345.27．2J．201234212222-2223.28．J．2012476436-439.29GonzalezSBinatoＲGuidaLetal．Conservedtranscriptionfactorbindingsitessuggestanactivatorbasalpromoterandadistalinhib-itorinthegalaningenepromoterinmouseEScellsJ．Gene20145382228-234.30．J．2013294295-298.2014-07-202015-01-29檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪《》[e-mail][e-mail]//．yxzszz．com·0242·201572113MedicalＲecapitulateJul．2015Vol．21No．13