乳头瘤病毒感染的免疫学特性①

(,100730)R37319A10002484X(2003)0920659204(Papillomavirus,PV)DNA,,,(humanpapillomavirus,HPV)(),HPV80,HPVHPV12347102629,HPV589121415171925364650,HPV6113441445155,HPV1618HPV61190%,HPV,,,,HPVPV,PVHPV,,PV,HPVPV1PVHPV55nm,DNA,,DNA,8kb,HPV8(ORF),3:,:(1964-),;(1973-),,,,6(E1E6),;,L1L2ORFS,L1L2,;(URR),,,2PVHPV1HPV,HPV,PV,PVPVPVHPV,,HPV(2050)S,E1E2DNA,E6E7E5,,,E4L1L2,,,,,9569,,,3,3,,,,,HPV,,E6E7,,,HPV,,,HPV,,HPV3PV311HPVHPV,HPV;,;,;,DNA;HPV(HSIL);HGSIL2HPVHPV4HPVHIV4,5,HIVCD4THPV6,CD4THPVHPV,CD8,,,CD4,CD8IL22,,CD45ROHLA2DRICAM21,7Th1(DTH)312(COPV)PVCOPVPV8,PV,,COPV68,1216,,Ni2chollsCOPV978,Langerhans,CD4T,T,CD8+,T,CD8+910,,COPVL17,8,COPVL1IgG8,1112COPV313CD4TPVTh1,,,E6E7DTH10212DTH12,CD8Th12Th2,13DeGruijlHPV216E7T,HPV(99%)T,41%14HPVHPV26066200319(WIL)HPV26E7L115HPV26E7L1WIL75%(n=24),WIL(CD4,CD8,TCRTCR),WILHPV26E7L1TL1E7CTL,,(CRPV)SelvakumarE2T16,E1E217E2BPV,E718,,HPV,314TCTLHPVHPVCTLHPVNaka2gawa,9HPV,11HPV216CINCTL,(63%),CIN14%,CTLCD4CD819PBMC,HPVCTL20HPVCTL,,CINHPVE7CTL,HLA()21315HPV,HPV22,L123,HPVVLPELISAHPV,HPVL1,,,HPVHPV588,HPV216,186DNA18,5915%,5411%6818%,HPVHPV,HPVDNA,24E6E725,DeGruijlELISAHPVHPV216E726,3,,IgGIgG2,IgG1IgG2,Th1,Th2StanleyE227,,RIPAE2IgA28,HPVHPV,,CD4TTh1,,CD4THIV,HPVCD4THPVCD4THPV,NKCTL,,VLPVLPHPV29166941BryanJT,BrownDR.Transmissionofhumanpapillomavirustype11in2fectionbydesquamatedcornifiedcellsJ.Virology,2001;281:35242.2HerreroR,HildesheimA,BratticCetal.Population2basedstudyofhu2manpapillomavirusinfectionandcervicalneoplasiainruralCostaRicaJ.JNatlCancerInst,2000;92(6):4642474.3BentonEC,ArendsMJ.HumanpapillomavirusintheimmunosuppressedM.In:LaceyCed.Papillomavirusreviews:currentresearchonpapillo2maviruses.Leeds:LeedsUniverstityPress,1996:2712279.4FruchterRG,MaimanM,SedilisAetal.MultiplerecurrencesofcervicalintraepithelialneoplasiainwomenwiththehumanimmunodeficiencyvirusJ.ObstetGynecol,1996;87:3882344.5FennemaJSA,VanAmeijenEJC,CoutinhoPAetal.HIV,sexuallytransmitteddiseasesandgynaecologicdisordersinwomen:increasedriskforgenitalherpesandwartsamongHIV2infectedprostitutesinAmsterdamJ.AIDS,1995;9:107121078.6PalefskyJM,MinkoffH,KalishLAetal.Cervicovaginalhumanpapillo2mavirusinfectioninhumanimmunodeficiencyvirus21(HIV)2positiveandhigh2riskHIV-negativewomenseecommentsJ.JNatlCancerInst,1999;91(3):2262236.7ColemanN,BirleyHD,RentonAMetal.Immunologicaleventsinre2gressinggenitalwartsJ.AmJClinPathol,1994;102(6):7682774.8NichollsPK,KlaunbergBA,MooreRAetal.Naturallyoccurring,non2regresingcanineoralpapillomavirusinfection:hostimmunity,viruscharac2terization,andexperimentalinfectionJ.Virology,1999;265(2):3652374.9NichollsPK,MoorePF,AndersonDMetal.RegressionofcanineoralpapillomasisassociatedwithinfiltrationofCD4+andCD8+lymphocytesJ.Virology,2001;283:31239.10McLeanCS,SterlingJS,MowatJetal.Delayedtypehypersensitiveityresponsetothehumanpapillomavirustype16E7proteininamousemodelJ.JGenVirol,1993;74:2392245.11ChambersMA,StaceySN,ArrandJRetal.Delayed2typehypersensi2tivityresponsetohumanpapillmavirustype16E6proteininamousemodelJ.JGenVirol,1994;75(Pt1):1652169.12ChambersMA,WeiZ,ColemanNetal.Naturalpresentationofhu2manpapillomavirustype216E7proteintoimmunocompetentmiceresultsinantigen2specificsensitizationorsustainedunresponsivenessJ.EurJImmunol,1994;24(3):7382745.13LopezMC,StanleyMA.Cytokineprofileofdraininglymphnodelym2phoctesinmicegraftedwithsygeneickeratinocytesexpressinghumanpapillmavirustype16E7proteinJ.JGenVirol,2000;81(Pt5):117521182.14deGruijlTD,BontkesHJ,StudartMJetal.Tcellproliferativere2sponsesagainsthumanpapillomavirustype16E7oncoproteinaremostprominentincervicalintraepithelialneoplasiapatientswithapersistentviralinfectionJ.JGenVirol,1996;77(Pt9):218322191.15HongK,GreerCE,KetterNetal.Isolationandcharacterizationofhu2manpapillomavirustype62specificTcellsinfiltratinggenitalwartsJ.JVirol,1997;71(9):642726432.16SelvakumarR,AhmedR,WettsteinFO.TumorregressionisassociatedwithaspecificimmuneresponsetotheE2ofcottontailrabbitpapilloma2virusstimulatesregressionofvirus2inducedpapillomasJ.JVirol,1995;69(1):6022605.17SelvakumarR,BorensteinLA,LinYLetal.Immunizationwithnon2structrualproteinsE1andE2ofcottontailrabbitpapillomavirusstimu2latesregressionofvirus2inducedpapillomasJ.JVirol,1995;69(1):6022605.18McGarvieGM,GrindlayGJ,ChandrachudLMetal.TcellresponsestoBPV24E7duringinfectionandmappingofTcellepitopesJ.Virolo2gy,1995;206(1):5042510.19NakagawaM,StitesDP,PalefskyJMetal.CD42positiveandCD82pos2itivecytotoxicTlymphocytescontributetohumanpapillomavirustype16E6andE7responsesJ.ClinDiagnLabImmunol,1999;6(4):4942498.20EvansEM,ManS,EvansASetal.Infiltrationofcervicalcancertissuewithhumanpapillomavirus2specificcytotoxicTlymphocytesJ.CancerRes,1997;57(14):294322950.21YoudeSJ,DunbarPR,EvansEMetal.Useoffluorogenichistocom2patibilityleukocyteantigen2A30201PHPV16E7peptidecomplexestoisolaterarehumancytotoxicT2lymhocyte2recognizingendogenoushumanpapillomavirusantigensJ.CancerRes,2000;60(2);3652371.22LutznerMA.Papillomaviruslesionsinimmunodepressionandimmuno2suppressionJ.ClinDermatol,1985;3(4):1652169.23StanleyMA.GenitaIpapillomaviruses2prospect