一次性输液器药物相容性及安全性分析-沈亦红

2012－06－13310009〔〕TH77〔〕A〔〕1002－2376201208－0001－04〔〕。、、8。DEHPPVC。〔〕PVC、50PVC、TPE、PEC、。2－DEHP。PVCDEHPDEHPPVC。DEHP/DEHP。Direc-tive2007/47/EC67/548/EECICMRCat.1or2、。REACHRegistrationEvalu-ationAuthorizationandRestrictionofChemicals、、DEHP15SVHCsSVHCSubstancesofVeryHighCon-cern。DEHPDOPPVC、、。PVCDEHP。。。11.1。1。。。。、、。。2PVC1201208DEHP。DEHP。。。3DEHP。PVCDEHP。。DEHP。。1.2。。①《2010》。100%②DEHP－。22.1、－7890A－5975C、UV2552、BSA224S。111201004192221003112.21277nm2293nm3266nm45250nm6207nm78200nm。DEHPGC－msHP－5MS30m×0.25mm×0.25μm150℃0.5min20℃/min280℃7min280℃EI230℃150℃280℃1μL51≥99.99%1.5mL/minTICSIM。2.3。5mL/min0min、15min、30min、60min、90min290min100mL5mL5minDEHP8。、、1//1－l00ml500mg/061000892100ml500mg/0907005632ml20mg/0910034250ml50g/090800259510ml400mg/201002616－1ml0.1g/201001197250ml12.5g/090113281ml5mg/201008032MedicalEquipmentVol.25No.082/%0min15min30min60min90min110097.799.699.799.7210097.499.899.699.8110099.899.999.899.9210099.999.899.999.9110099.799.799.699.7210099.599.599.699.5110095.996.797.698.4210096.197.698.498.4110098.199.399.599.5210097.398.6100100110097.398.999.299.2210096.998.599.599.6110081.385.288.390.2210080.884.687.991.3110098.999.199.399.3210098.799.299.499.5。3、。、。。10μg20～25μg。。20mL。、、、、、、、、。1P．MoorhatchandW．L．ChiouAm．J．Hosp．Pharm311974149～152．2R．VenkataramananG．J．BurchartandR．J．Ptach-cinskiAm．J．Hosp．Pharm4319862800～2802．3D．M．C．BartherE．B．RockardI．J．Pou-liquenS．M．RabouanandP．Y．CourtoisAm．J．Hosp．Pharm5119942706～2709．4ShibataNIkrnoYTsubakimomoYetal．Absorp-tionandpharmacokineticsofcyclosporineAinrelationtomodeofinfusioninbonemarrowtransplantpatientsJ．BoneMarrowTranspla－nt2000256633．5SchneiderJJGoodPRavenscroftPJ．Effectoftubingonlossofclonazepamadministeredbycontinuoussubcu-taneousinfusionJ．JPainSymptomManage2006316563．6.J.20031411694.7.J.2005258764－765.8.J.20031411694－695.9.J.20022210618.10..6.1985.2062510.11..2003239573－574.32012082012－05－28RFID362000〔〕TP31〔〕B〔〕1002－2376201208－0004－02〔〕。RFID、、、。RFID。〔〕RFIDC/SRFID、、、。《》RFID。、、、、。1RFIDRadioFrequencyIdentificationRFID。RFID、、、、、、、。RFIDRFIDRFID。2。。。。RFIDRFID櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉櫉DrugCompatibilityandSafetyAnalysisofInfusionSetsforSingleUseShenYiHongZhejiangInstituteofMedicalInstrumentHangzhou310009AbstractInthispaperfluidpathway－druginteractionwayssafetyissuesduringinjectionandinfusionhavebeenwelldis-cussed．Besidesdifferenttypesofdrugseffectfactorsclassificationofdrugcharacteristicshavebeensummarizedbasedonthegreatnumberofrelevantliteratureswhichmayresultinadsorptioneffectofinfusionsetsforsingleuse．Meanwhilethereare8typicaltypesofdrugsusuallyusedintheinfusiontherapyhavebeenchoseninthisresearchinordertostudytheadsorptionofinfusiondrugsontotheinfusionsets．InadditionthePolyvinylChloridePVCinfusionsetswhichplasticizedbyDi2－ethylhexylPhthalateDEHPhasalsobeendescribedanddiscussedinthepaper．KeywordsPVCsyringes/infusionbagsDrugabsorbabilityPlasticizer4MedicalEquipmentVol.25No.08