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554300。1。20121.9414.3%604.2%。201322.0214.8%。21996FDA19971999。AD。TM。A3-4-wittig1--4-56--1-5。Aldol6420134-80℃、LDA。50.8%62%*82%=50.8%。B44、、。75.8%98%*85%*100%*91%=75.8%。。NaHNaOH、。B5。4-N--4-56--1-4。C644-、、、。58.5%87%*83%*8l%=58.5%。。。D7-1120044。、、、。。、LDA。A50.8%LDA。B、。C。DBCC75.9%2~3。。*201262-24。1.J..201103.2http//.gov.cn/jrzg/2013-04/14/content_2377594.htm.3SugimotoHTsuehiyaYHigurashiKetalCyclica-minecompounditsuseandPharmaceuticalcomposi-tionscompromisingitPUS48958411989.4YoichilimuraIbaarakiPorcessforproductionofdonepezi1derivativePUS62520812001.5KaspiJosephGivatayimProeessforthePreparationofDonepezilPEP13866072004.6StephenLenskyprocessforthepreparationofbenzyl-piperidylmethyl-indanonesPUS56060641997.7.D..2005.8.D..2006.9.J..2011332.175-176.10...2012359.12-16.11.D..2013.74201312
本文标题:盐酸多奈哌齐的合成路线图解-李玉龙
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