多糖药物载体

CarbohydratePolymers86(2011)1425–1438ContentslistsavailableatScienceDirectCarbohydratePolymersjournalhomepage:—PromisingbiodegradablecarriersfordrugdeliverysystemsC.A.García-González∗,M.Alnaief,I.Smirnova∗InstituteofThermalSeparationProcesses,HamburgUniversityofTechnology,Eißendorferstraße38,D-21073Hamburg,GermanyarticleinfoArticlehistory:Received2May2011Receivedinrevisedform21June2011Accepted23June2011Availableonline1July2011Keywords:PolysaccharideAerogelAerogeltechnologyDrugcarrierNanoporousbio-basedmaterialabstractPolysaccharidesareregardedaskeyingredientsfortheproductionofbio-basedmaterialsinlifesci-ences(e.g.,food,cosmetics,medicaldevices,pharmaceutics).Thebiodegradabilityandbiocompatibilityofthesebiopolymers,coupledtothelargevarietyofchemicalfunctionalitiestheyencompass,makethempromisingcarriersfordrugdeliverysystems.Aerogelsareaspecialclassofnanoporousmaterialswithgrowinginterestinbiomedicalandpharmaceuticalapplicationsduetotheiropenporestructureandhighsurfacearea.Polysaccharide-basedaerogelsresultinhighlyporous(ε=90–99%),lightweight(=0.07–0.46g/cm3)drugcarrierswithhighsurfacearea(Sa=70–680m2/g),abletoprovideenhanceddrugbioavailabilityanddrugloadingcapacity.Thisreviewfocusesonthestate-of-the-artoftheproduc-tionofpolysaccharide-basedaerogelswithemphasisontheinfluenceofprocessingparametersontheresultingendmaterialproperties.Casestudiesonpolysaccharide-basedaerogelsfromseveralsourcesandownresultsaswellastheirbehaviorregardingdrugloadingcapacityandreleasearedescribed.©2011ElsevierLtd.Allrightsreserved.Contents1.Introduction..........................................................................................................................................14262.Processingpathway..................................................................................................................................14262.1.Gelpreparation...............................................................................................................................14272.2.Solventexchange.............................................................................................................................14272.3.Geldrying.....................................................................................................................................14283.Aerogelproductionstrategies.......................................................................................................................14283.1.Monolithaerogelprocessing.................................................................................................................14283.2.Particleaerogelprocessing...................................................................................................................14284.Casestudiesonpolysaccharideaerogels............................................................................................................14294.1.Starch.........................................................................................................................................14294.2.Pectin.........................................................................................................................................14314.3.Alginate.......................................................................................................................................14314.4.Chitinandchitosan...........................................................................................................................14314.5.Carrageenan..................................................................................................................................14334.6.Agar...........................................................................................................................................14334.7.Cellulose......................................................................................................................................14335.Aerogelascarriers:drugreleaseassessment........................................................................................................14336.Futureprospectsandoutlook........................................................................................................................1435Acknowledgements..................................................................................................................................1435References...........................................................................................................................................1436∗Correspondingauthors.Tel.:[phone];fax:[phone].E-mailaddresses:[e-mail](C.A.García-González),[e-mail](I.Smirnova).0144-8617/$–seefrontmatter©2011ElsevierLtd.Allrightsreserved.doi:10.1016/j.carbpol.2011.06.0661426C.A.García-Gonzálezetal./CarbohydratePolymers86(2011)1425–1438NomenclatureSaspecificBET-surfacearea(m2/g)Vpmesoporevolume(cm3/g)Prporeradiu